Paraneoplastic cerebellar degeneration with anti-Yo antibody in a patient with HER2/neu overexpressing breast cancer: A case report with a current literature review

Shin Ogita, Omar H. Llaguna, Sheldon M. Feldman, Ronald Blum

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Paraneoplastic cerebellar degeneration (PCD) is a rare paraneoplastic syndrome, occurring in <1% of breast cancers. We describe a 32-year-old female presenting with ataxia subsequently diagnosed with poorly differentiated breast cancer. She was serum anti-Yo antibody positive, with estrogen/progesterone receptor negative and HER2/neu receptor positive breast cancer. Neurological symptoms progressed despite modified radical mastectomy, supraclavicular lymphadenectomy, intravenous immunoglobulin, corticosteroids, transtuzumab, and combination chemotherapy. We performed a literature search, which found a possible association between anti-Yo positive PCD and HER2/neu-expressing breast cancer.

Original languageEnglish (US)
Pages (from-to)382-384
Number of pages3
JournalBreast Journal
Volume14
Issue number4
DOIs
StatePublished - Jul 1 2008

Keywords

  • Anti-yo antibody
  • Breast cancer
  • Cerebellar degeneration
  • Her2/neu
  • Paraneoplastic syndrome

ASJC Scopus subject areas

  • Internal Medicine
  • Surgery
  • Oncology

Fingerprint Dive into the research topics of 'Paraneoplastic cerebellar degeneration with anti-Yo antibody in a patient with HER2/neu overexpressing breast cancer: A case report with a current literature review'. Together they form a unique fingerprint.

  • Cite this