Background: The basic mechanisms of sulfotransferase (SULT) catalysis are not yet well understood. Results: A complete, quantitative model of human SULT2A1 catalysis is constructed.
Conclusion: The model resolves extant ambiguities and establishes a catalytic paradigm for the SULT family.
Significance: SULTs regulate the functions of thousands of signaling small molecules. Understanding their mechanisms is fundamental to understanding their biological functions.
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology