Paradigms of sulfotransferase catalysis the mechanism of sult2a1

Ting Wang, Ian Cook, Charles N. Falany, Thomas S. Leyh

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Background: The basic mechanisms of sulfotransferase (SULT) catalysis are not yet well understood. Results: A complete, quantitative model of human SULT2A1 catalysis is constructed.

Conclusion: The model resolves extant ambiguities and establishes a catalytic paradigm for the SULT family.

Significance: SULTs regulate the functions of thousands of signaling small molecules. Understanding their mechanisms is fundamental to understanding their biological functions.

Original languageEnglish (US)
Pages (from-to)26474-26480
Number of pages7
JournalJournal of Biological Chemistry
Volume289
Issue number38
DOIs
StatePublished - Sep 19 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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