Paradigms of sulfotransferase catalysis the mechanism of sult2a1

Ting Wang; Ian Cook; Charles N. Falany; Thomas S. Leyh

doi:10.1074/jbc.M114.573501

Paradigms of sulfotransferase catalysis the mechanism of sult2a1

Ting Wang, Ian Cook, Charles N. Falany, Thomas S. Leyh

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Background: The basic mechanisms of sulfotransferase (SULT) catalysis are not yet well understood. Results: A complete, quantitative model of human SULT2A1 catalysis is constructed.

Conclusion: The model resolves extant ambiguities and establishes a catalytic paradigm for the SULT family.

Significance: SULTs regulate the functions of thousands of signaling small molecules. Understanding their mechanisms is fundamental to understanding their biological functions.

Original language	English (US)
Pages (from-to)	26474-26480
Number of pages	7
Journal	Journal of Biological Chemistry
Volume	289
Issue number	38
DOIs	https://doi.org/10.1074/jbc.M114.573501
State	Published - Sep 19 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: The basic mechanisms of sulfotransferase (SULT) catalysis are not yet well understood. Results: A complete, quantitative model of human SULT2A1 catalysis is constructed.Conclusion: The model resolves extant ambiguities and establishes a catalytic paradigm for the SULT family.Significance: SULTs regulate the functions of thousands of signaling small molecules. Understanding their mechanisms is fundamental to understanding their biological functions.",

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AU - Cook, Ian

AU - Falany, Charles N.

AU - Leyh, Thomas S.

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AB - Background: The basic mechanisms of sulfotransferase (SULT) catalysis are not yet well understood. Results: A complete, quantitative model of human SULT2A1 catalysis is constructed.Conclusion: The model resolves extant ambiguities and establishes a catalytic paradigm for the SULT family.Significance: SULTs regulate the functions of thousands of signaling small molecules. Understanding their mechanisms is fundamental to understanding their biological functions.

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Paradigms of sulfotransferase catalysis the mechanism of sult2a1

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