Paracoccidioides spp. and Histoplasma capsulatum: Current and New Perspectives for Diagnosis and Treatment

C. P. Taborda, R. Buccheri, G. Benard, A. N. Duarte-Neto, Joshua D. Nosanchuk, L. R. Travassos

Research output: Contribution to journalArticle

Abstract

The thermally-dimorphic systemic fungal group includes several important human pathogens: Blastomyces dermatitides, Coccidioides immitis and C. posadasii, Histoplasma capsulatum, Paracoccidioides brasiliensis, P. lutzii, and Talaromyces (Penicillium) marneffei. They usually are geographically restricted and have natural habitats in soil or in plants, and when fungal propagules invade mammalian host by inhalation, they initiate an inflammatory reaction that can result in self-resolution of the infection or cause an acute or chronic disease. In the setting of the AIDS pandemic and the developments in modern medicine, such as immunosuppressive therapy in cancer surgery patients and in transplantation and autoimmune diseases, the incidence of endemic mycoses has progressively increased. Another important factor of the increased incidence of systemic mycoses in certain regions is the progressive devastation of tropical and subtropical forests. In this review, we focus on two of the most important systemic mycoses: paracoccidioidomycosis and histoplasmosis, and their major characteristics in epidemiology, clinical aspects and laboratorial diagnosis.

Original languageEnglish (US)
Pages (from-to)1333-1348
Number of pages16
JournalCurrent Topics in Medicinal Chemistry
Volume18
Issue number15
DOIs
StatePublished - Jan 1 2018

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Paracoccidioides
Histoplasma
Mycoses
Talaromyces
Blastomyces
Coccidioides
Paracoccidioidomycosis
Histoplasmosis
Modern 1601-history
Penicillium
Incidence
Acute Disease
Pandemics
Dermatitis
Immunosuppressive Agents
Inhalation
Autoimmune Diseases
Ecosystem
Acquired Immunodeficiency Syndrome
Epidemiology

Keywords

  • AIDs
  • Chronic disease
  • Histoplasmosis
  • Infection
  • Paracoccidioidomycosis
  • Penicillium.

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Paracoccidioides spp. and Histoplasma capsulatum : Current and New Perspectives for Diagnosis and Treatment. / Taborda, C. P.; Buccheri, R.; Benard, G.; Duarte-Neto, A. N.; Nosanchuk, Joshua D.; Travassos, L. R.

In: Current Topics in Medicinal Chemistry, Vol. 18, No. 15, 01.01.2018, p. 1333-1348.

Research output: Contribution to journalArticle

Taborda, C. P. ; Buccheri, R. ; Benard, G. ; Duarte-Neto, A. N. ; Nosanchuk, Joshua D. ; Travassos, L. R. / Paracoccidioides spp. and Histoplasma capsulatum : Current and New Perspectives for Diagnosis and Treatment. In: Current Topics in Medicinal Chemistry. 2018 ; Vol. 18, No. 15. pp. 1333-1348.
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