Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancer

Nan Haw Chow, Paul Cairns, Claus F. Eisenberger, Mark P. Schoenberg, David C. Taylor, Jonathan I. Epstein, David Sidransky

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Papilloma and papillary hyperplasia (PH) have been proposed to be the putative precursor lesions of papillary transitional-cell carcinoma of the urinary bladder. We examined 15 PH lesions and 4 papillomas for loss of heterozygosity (LOH) at 17 microsatellite markers on 9 chromosomal arms. Eight of 15 (53%) PHs were clonal, demonstrating LOH of at least 1 microsatellite marker. In contrast, none of the papillomas showed any genetic changes among the markers tested. In PH, chromosomal arm 9q was the most frequently lost (4/15), followed by 9p and 18q (n = 2) and, less frequently, 8p, 10q, 11p and 17p (n = 1). Furthermore, 2 hyperplastic lesions demonstrated LOH at 9q only, confirming the notion that allelic loss on chromosomal arm 9q is among the earliest events in bladder-cancer progression. In 1 patient, identical LOH patterns were observed between PH and a recurrent transitional-cell carcinoma. Our molecular data demonstrate that at least a proportion of PHs represent pre-cancerous lesions of the bladder that subsequently progress to papillary bladder cancer. Moreover, chromosomal arm 9q may harbor a tumor-suppressor gene(s) inactivated in the earliest stages of human bladder tumorigenesis. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)514-518
Number of pages5
JournalInternational Journal of Cancer
Volume89
Issue number6
DOIs
StatePublished - Nov 20 2000
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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