Papillary lesions of the breast

Evaluation with stereotactic directional vacuum-assisted biopsy

C. L. Mercado, D. Hamele-Bena, C. Singer, Tova C. Koenigsberg, E. Pile-Spellman, H. Higgins, S. J. Smith

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

PURPOSE: To evaluate the use of stereotactic directional vacuum-assisted biopsy (SDVAB) in diagnosing and managing papillary lesions of the breast. MATERIALS AND METHODS: The authors retrospectively reviewed the mammographic and histopathologic findings of 26 cases in which papillary lesions were diagnosed at SDVAB. In all cases, subsequent surgical excision (n = 20) or long-term imaging follow-up (n = 6) was performed and correlated with findings at SDVAB. RESULTS: SDVAB of 26 lesions yielded tissue that was classified as benign in 12, atypical in six, and malignant in eight. Of the 12 lesions that were diagnosed as histologically benign at SDVAB, six were surgically excised. Of these six lesions, five yielded benign correlative results. The sixth lesion was thought to be discordant with the imaging findings, and was surgically excised and determined to be malignant. Of the six benign lesions that were not surgically sampled for biopsy, five decreased in size and one was not seen at radiographic follow-up. Of the six lesions diagnosed as atypical at SDVAB that were surgically excised, one was benign and five were atypical. None proved to be malignant. Of the eight lesions diagnosed as malignant at SDVAB, surgical excision demonstrated ductal carcinoma in situ in all eight; two also had foci of invasive carcinoma. CONCLUSION: Benign and malignant papillary lesions of the breast can be reliably diagnosed at SDVAB when the SDVAB results correlate with the imaging findings. However, the extent of malignant papillary disease may be underestimated at SDVAB; in our study, invasive carcinoma was later discovered in 25% of patients with this diagnosis.

Original languageEnglish (US)
Pages (from-to)650-655
Number of pages6
JournalRadiology
Volume221
Issue number3
StatePublished - 2001
Externally publishedYes

Fingerprint

Vacuum
Breast
Biopsy
Carcinoma
Carcinoma, Intraductal, Noninfiltrating

Keywords

  • Breast neoplasms, diagnosis
  • Breast, biopsy
  • Papilloma

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Mercado, C. L., Hamele-Bena, D., Singer, C., Koenigsberg, T. C., Pile-Spellman, E., Higgins, H., & Smith, S. J. (2001). Papillary lesions of the breast: Evaluation with stereotactic directional vacuum-assisted biopsy. Radiology, 221(3), 650-655.

Papillary lesions of the breast : Evaluation with stereotactic directional vacuum-assisted biopsy. / Mercado, C. L.; Hamele-Bena, D.; Singer, C.; Koenigsberg, Tova C.; Pile-Spellman, E.; Higgins, H.; Smith, S. J.

In: Radiology, Vol. 221, No. 3, 2001, p. 650-655.

Research output: Contribution to journalArticle

Mercado, CL, Hamele-Bena, D, Singer, C, Koenigsberg, TC, Pile-Spellman, E, Higgins, H & Smith, SJ 2001, 'Papillary lesions of the breast: Evaluation with stereotactic directional vacuum-assisted biopsy', Radiology, vol. 221, no. 3, pp. 650-655.
Mercado CL, Hamele-Bena D, Singer C, Koenigsberg TC, Pile-Spellman E, Higgins H et al. Papillary lesions of the breast: Evaluation with stereotactic directional vacuum-assisted biopsy. Radiology. 2001;221(3):650-655.
Mercado, C. L. ; Hamele-Bena, D. ; Singer, C. ; Koenigsberg, Tova C. ; Pile-Spellman, E. ; Higgins, H. ; Smith, S. J. / Papillary lesions of the breast : Evaluation with stereotactic directional vacuum-assisted biopsy. In: Radiology. 2001 ; Vol. 221, No. 3. pp. 650-655.
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abstract = "PURPOSE: To evaluate the use of stereotactic directional vacuum-assisted biopsy (SDVAB) in diagnosing and managing papillary lesions of the breast. MATERIALS AND METHODS: The authors retrospectively reviewed the mammographic and histopathologic findings of 26 cases in which papillary lesions were diagnosed at SDVAB. In all cases, subsequent surgical excision (n = 20) or long-term imaging follow-up (n = 6) was performed and correlated with findings at SDVAB. RESULTS: SDVAB of 26 lesions yielded tissue that was classified as benign in 12, atypical in six, and malignant in eight. Of the 12 lesions that were diagnosed as histologically benign at SDVAB, six were surgically excised. Of these six lesions, five yielded benign correlative results. The sixth lesion was thought to be discordant with the imaging findings, and was surgically excised and determined to be malignant. Of the six benign lesions that were not surgically sampled for biopsy, five decreased in size and one was not seen at radiographic follow-up. Of the six lesions diagnosed as atypical at SDVAB that were surgically excised, one was benign and five were atypical. None proved to be malignant. Of the eight lesions diagnosed as malignant at SDVAB, surgical excision demonstrated ductal carcinoma in situ in all eight; two also had foci of invasive carcinoma. CONCLUSION: Benign and malignant papillary lesions of the breast can be reliably diagnosed at SDVAB when the SDVAB results correlate with the imaging findings. However, the extent of malignant papillary disease may be underestimated at SDVAB; in our study, invasive carcinoma was later discovered in 25{\%} of patients with this diagnosis.",
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AB - PURPOSE: To evaluate the use of stereotactic directional vacuum-assisted biopsy (SDVAB) in diagnosing and managing papillary lesions of the breast. MATERIALS AND METHODS: The authors retrospectively reviewed the mammographic and histopathologic findings of 26 cases in which papillary lesions were diagnosed at SDVAB. In all cases, subsequent surgical excision (n = 20) or long-term imaging follow-up (n = 6) was performed and correlated with findings at SDVAB. RESULTS: SDVAB of 26 lesions yielded tissue that was classified as benign in 12, atypical in six, and malignant in eight. Of the 12 lesions that were diagnosed as histologically benign at SDVAB, six were surgically excised. Of these six lesions, five yielded benign correlative results. The sixth lesion was thought to be discordant with the imaging findings, and was surgically excised and determined to be malignant. Of the six benign lesions that were not surgically sampled for biopsy, five decreased in size and one was not seen at radiographic follow-up. Of the six lesions diagnosed as atypical at SDVAB that were surgically excised, one was benign and five were atypical. None proved to be malignant. Of the eight lesions diagnosed as malignant at SDVAB, surgical excision demonstrated ductal carcinoma in situ in all eight; two also had foci of invasive carcinoma. CONCLUSION: Benign and malignant papillary lesions of the breast can be reliably diagnosed at SDVAB when the SDVAB results correlate with the imaging findings. However, the extent of malignant papillary disease may be underestimated at SDVAB; in our study, invasive carcinoma was later discovered in 25% of patients with this diagnosis.

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