Pancreatic neuroendocrine paraneoplastic optic neuropathy: Confirmation with antibody to optic nerve and hepatic metastasis

Thomas L. Slamovits, Jerome B. Posner, Diane L. Reidy, Charles E. Thirkill, John L. Keltner

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A 68-year-old woman presented with bilateral visual loss as the only clinical manifestation of an occult pancreatic nonsecretory neuroendocrine tumor (NET). The suspected diagnosis of paraneoplastic optic neuropathy was confirmed using immunofluorescence assays to demonstrate the presence of antibodies in the patient's serum that reacted with antigen(s) in the optic nerve and in the pancreatic NET hepatic metastasis. Treatment of the underlying cancer was followed by marked improvement in visual function.

Original languageEnglish (US)
Pages (from-to)21-25
Number of pages5
JournalJournal of Neuro-Ophthalmology
Volume33
Issue number1
DOIs
StatePublished - Mar 2013

Fingerprint

Paraneoplastic Polyneuropathy
Optic Nerve Diseases
Neuroendocrine Tumors
Optic Nerve
Neoplasm Metastasis
Antibodies
Liver
Fluorescent Antibody Technique
Antigens
Serum
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Ophthalmology

Cite this

Pancreatic neuroendocrine paraneoplastic optic neuropathy : Confirmation with antibody to optic nerve and hepatic metastasis. / Slamovits, Thomas L.; Posner, Jerome B.; Reidy, Diane L.; Thirkill, Charles E.; Keltner, John L.

In: Journal of Neuro-Ophthalmology, Vol. 33, No. 1, 03.2013, p. 21-25.

Research output: Contribution to journalArticle

Slamovits, Thomas L. ; Posner, Jerome B. ; Reidy, Diane L. ; Thirkill, Charles E. ; Keltner, John L. / Pancreatic neuroendocrine paraneoplastic optic neuropathy : Confirmation with antibody to optic nerve and hepatic metastasis. In: Journal of Neuro-Ophthalmology. 2013 ; Vol. 33, No. 1. pp. 21-25.
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