Pallidal deep brain stimulation for dystonia

A case series. Clinical article

Melita T. Petrossian, Lisa R. Paul, Trisha J. Multhaupt-Buell, Christine Eckhardt, Michael T. Hayes, Ann Christine Duhaime, Emad N. Eskandar, Nutan Sharma

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Object. Pallidal deep brain stimulation (DBS) is a treatment option for those with early-onset dystonia. However, there are limited data on long-term outcome and treatment complications. The authors report on the short- and long-term effects of pallidal DBS in a cohort of patients with early-onset dystonia. Methods. Fourteen consecutive pediatric patients with early-onset dystonia were systematically evaluated and treated. The duration of follow-up ranged from 16 to 84 months. Results. There were no immediate postoperative complications. At last follow-up, 12 of the 14 patients displayed a significant decline in the Burke-Fahn-Marsden Dystonia Rating Scale motor subscale score, with an average decrease of 62% ± 8.4%. The most common hardware complication was lead fracture (14.3%). Conclusions. These data provide further evidence that DBS is a safe and effective treatment for those with early-onset dystonia.

Original languageEnglish (US)
Pages (from-to)582-587
Number of pages6
JournalJournal of Neurosurgery: Pediatrics
Volume12
Issue number6
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Fingerprint

Deep Brain Stimulation
Dystonia
Pediatrics
Therapeutics

Keywords

  • Deep brain stimulation
  • Early-onset dystonia
  • Functional neurosurgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Petrossian, M. T., Paul, L. R., Multhaupt-Buell, T. J., Eckhardt, C., Hayes, M. T., Duhaime, A. C., ... Sharma, N. (2013). Pallidal deep brain stimulation for dystonia: A case series. Clinical article. Journal of Neurosurgery: Pediatrics, 12(6), 582-587. https://doi.org/10.3171/2013.8.PEDS13134

Pallidal deep brain stimulation for dystonia : A case series. Clinical article. / Petrossian, Melita T.; Paul, Lisa R.; Multhaupt-Buell, Trisha J.; Eckhardt, Christine; Hayes, Michael T.; Duhaime, Ann Christine; Eskandar, Emad N.; Sharma, Nutan.

In: Journal of Neurosurgery: Pediatrics, Vol. 12, No. 6, 01.12.2013, p. 582-587.

Research output: Contribution to journalArticle

Petrossian, MT, Paul, LR, Multhaupt-Buell, TJ, Eckhardt, C, Hayes, MT, Duhaime, AC, Eskandar, EN & Sharma, N 2013, 'Pallidal deep brain stimulation for dystonia: A case series. Clinical article', Journal of Neurosurgery: Pediatrics, vol. 12, no. 6, pp. 582-587. https://doi.org/10.3171/2013.8.PEDS13134
Petrossian MT, Paul LR, Multhaupt-Buell TJ, Eckhardt C, Hayes MT, Duhaime AC et al. Pallidal deep brain stimulation for dystonia: A case series. Clinical article. Journal of Neurosurgery: Pediatrics. 2013 Dec 1;12(6):582-587. https://doi.org/10.3171/2013.8.PEDS13134
Petrossian, Melita T. ; Paul, Lisa R. ; Multhaupt-Buell, Trisha J. ; Eckhardt, Christine ; Hayes, Michael T. ; Duhaime, Ann Christine ; Eskandar, Emad N. ; Sharma, Nutan. / Pallidal deep brain stimulation for dystonia : A case series. Clinical article. In: Journal of Neurosurgery: Pediatrics. 2013 ; Vol. 12, No. 6. pp. 582-587.
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