Abstract
A mild and efficient Pd-catalyzed coupling of amides with 2-chloropyrimidines is described. The use of bidentate phosphines, such as Xantphos (7), as supporting ligands was found to be crucial for providing high yields of 2-(N-acylamino)pyrimidine coupling products 1.
Original language | English (US) |
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Pages (from-to) | 1020-1022 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 52 |
Issue number | 9 |
DOIs | |
State | Published - Mar 2 2011 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry