Paecilomyces sinusitis in an immunocompromised adult patient: Case report and review

R. Gucalp, P. Carlisle, P. Gialanella, S. Mitsudo, J. McKitrick, J. Dutcher

Research output: Contribution to journalArticle

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Abstract

A case of fungal sinusitis caused by Paecilomyces lilacinus that was unresponsive to amphotericin B and involved a patient with acute myeloid leukemia is described. Histologic examination of sinus tissue and periorbital bone demonstrated invasion by a fungus with septate hyphae, which was identified in culture as P. lilacinus. The isolate was resistant to amphotericin B but susceptible to itraconazole. The patient responded clinically when itraconazole was added to the treatment regimen. Invasive aspergillar infections are frequently diagnosed by histology. Other fungi such as Fusarium, Pseudallescheria, and Paecilomyces species also produce hyphae in tissue and can be confused with Aspergillus species. However, these pathogens may be resistant to amphotericin B. Since alternative therapy is now available for infections with some of the amphotericin B- resistant fungi, such as P. lilanicus, every effort should be made to recover the fungal pathogen so that effective treatment can be administered.

Original languageEnglish (US)
Pages (from-to)391-393
Number of pages3
JournalClinical Infectious Diseases
Volume23
Issue number2
StatePublished - 1996

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Paecilomyces
Sinusitis
Immunocompromised Host
Amphotericin B
Fungi
Itraconazole
Hyphae
Pseudallescheria
Fusarium
Aspergillus
Complementary Therapies
Infection
Acute Myeloid Leukemia
Histology
Bone and Bones
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Paecilomyces sinusitis in an immunocompromised adult patient : Case report and review. / Gucalp, R.; Carlisle, P.; Gialanella, P.; Mitsudo, S.; McKitrick, J.; Dutcher, J.

In: Clinical Infectious Diseases, Vol. 23, No. 2, 1996, p. 391-393.

Research output: Contribution to journalArticle

Gucalp, R, Carlisle, P, Gialanella, P, Mitsudo, S, McKitrick, J & Dutcher, J 1996, 'Paecilomyces sinusitis in an immunocompromised adult patient: Case report and review', Clinical Infectious Diseases, vol. 23, no. 2, pp. 391-393.
Gucalp, R. ; Carlisle, P. ; Gialanella, P. ; Mitsudo, S. ; McKitrick, J. ; Dutcher, J. / Paecilomyces sinusitis in an immunocompromised adult patient : Case report and review. In: Clinical Infectious Diseases. 1996 ; Vol. 23, No. 2. pp. 391-393.
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