p38 MAP kinase regulates stem cell apoptosis in human hematopoietic failure

Li Zhou, Joanna Opalinska, Amit K. Verma

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Myelodysplastic syndromes (MDS) are clonal stem cell disorders that lead to ineffective hematopoiesis and are common causes of low blood counts in the elderly. The exact molecular mechanisms regulating increased stem apoptosis in these disorders are not well defined. p38 MAPK activation is important in regulating the growth inhibitory signals of TNF-α, TGF-β and Interferons on human hematopoiesis. Our findings show that p38 MAPK is overactivated in myelodysplasia bone marrows and regulates hematopoietic stem cell apoptosis. Inhibition of p38 MAPK by genetic or pharmacologic means decreases apoptosis and stimulates in vitro hematopoiesis from primary MDS hematopoietic progenitors. These studies point to the potential efficacy of selective p38α inhibitor, SCIO-469, in human bone marrow failure.

Original languageEnglish (US)
Pages (from-to)534-537
Number of pages4
JournalCell Cycle
Volume6
Issue number5
StatePublished - Mar 1 2007

Fingerprint

Hematopoiesis
p38 Mitogen-Activated Protein Kinases
Stem cells
Stem Cells
Myelodysplastic Syndromes
Apoptosis
Bone
Bone Marrow
Hematopoietic Stem Cells
Interferons
Blood
Chemical activation
Growth

Keywords

  • Apoptosis
  • Bone marrow
  • Hematopoiesis
  • MAP kinase
  • MDS
  • p38

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Cite this

p38 MAP kinase regulates stem cell apoptosis in human hematopoietic failure. / Zhou, Li; Opalinska, Joanna; Verma, Amit K.

In: Cell Cycle, Vol. 6, No. 5, 01.03.2007, p. 534-537.

Research output: Contribution to journalArticle

Zhou, Li ; Opalinska, Joanna ; Verma, Amit K. / p38 MAP kinase regulates stem cell apoptosis in human hematopoietic failure. In: Cell Cycle. 2007 ; Vol. 6, No. 5. pp. 534-537.
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