p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models

Y. Wen, D. H. Yan, B. Wang, B. Spohn, Y. Ding, R. Shao, Yiyu Zou, K. Xie, M. C. Hung

Research output: Contribution to journalArticle

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Abstract

p202, an IFN-inducible protein, interacts with certain transcriptional activators leading to transcriptional repression. p202 expression has been associated with inhibition of cancer cell growth in vitro and in vivo. To examine a potential p202-mediated antitumor activity in pancreatic cancer, we used both ectopic and orthotopic xenograft models and demonstrated that p202 expression is associated with multiple antitumor activities that include inhibition of tumor growth, reduced tumorigenicity, prolonged survival, and remarkably, suppression of metastasis and angiogenesis. In vitro invasion assay also showed that p202-expressing pancreatic cancer cells are less invasive than those without p202 expression. That observation was supported by the findings that p202-expressing tumors showed reduced expression of angiogenic markers, such as interleukin 8 and vascular endothelial growth factor, and p202-expressing pancreatic cancer cells have reduced level of matrix metalloproteinase-2 activity, a secreted protease activity important for metastasis. Importantly, we demonstrated a treatment efficacy by using p202/SN2 liposome complex in a nude mice xenograft model, suggesting a feasibility of using the p202/SN2 liposome in future preclinical gene therapy experiments. Together, our results strongly suggest that p202 expression mediates multiple antitumor activities against pancreatic cancer and may provide a scientific basis for developing a p202-based gene therapy in pancreatic cancer treatment.

Original languageEnglish (US)
Pages (from-to)7142-7147
Number of pages6
JournalCancer Research
Volume61
Issue number19
StatePublished - Oct 1 2001
Externally publishedYes

Fingerprint

Pancreatic Neoplasms
Heterografts
Human Activities
Interferons
Proteins
Liposomes
Genetic Therapy
Neoplasm Metastasis
Neoplasms
Matrix Metalloproteinase 2
Growth
Interleukin-8
Nude Mice
Vascular Endothelial Growth Factor A
Peptide Hydrolases
Observation
In Vitro Techniques
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Wen, Y., Yan, D. H., Wang, B., Spohn, B., Ding, Y., Shao, R., ... Hung, M. C. (2001). p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models. Cancer Research, 61(19), 7142-7147.

p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models. / Wen, Y.; Yan, D. H.; Wang, B.; Spohn, B.; Ding, Y.; Shao, R.; Zou, Yiyu; Xie, K.; Hung, M. C.

In: Cancer Research, Vol. 61, No. 19, 01.10.2001, p. 7142-7147.

Research output: Contribution to journalArticle

Wen, Y, Yan, DH, Wang, B, Spohn, B, Ding, Y, Shao, R, Zou, Y, Xie, K & Hung, MC 2001, 'p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models', Cancer Research, vol. 61, no. 19, pp. 7142-7147.
Wen, Y. ; Yan, D. H. ; Wang, B. ; Spohn, B. ; Ding, Y. ; Shao, R. ; Zou, Yiyu ; Xie, K. ; Hung, M. C. / p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models. In: Cancer Research. 2001 ; Vol. 61, No. 19. pp. 7142-7147.
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