TY - JOUR
T1 - p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow
AU - Vidal, Anxo
AU - Zacharoulis, Stergios
AU - Guo, Wenjun
AU - Shaffer, David
AU - Giancotti, Filippo
AU - Bramley, Anna H.
AU - De La Hoz, Carmen
AU - Jensen, Kristian K.
AU - Kato, Daniel
AU - MacDonald, Daniel D.
AU - Knowles, Joseph
AU - Yeh, Nancy
AU - Frohman, Lawrence A.
AU - Rafii, Shahin
AU - Lyden, David
AU - Koff, Andrew
PY - 2005/5/10
Y1 - 2005/5/10
N2 - Neoangiogenesis involves both bone marrow-derived myelomonocytic and endothelial progenitor cells as well as endothelial cells coopted from surrounding vessels. Cytokines induce these cells to proliferate, migrate, and exit the cell cycle to establish the vasculature; however, which cell cycle regulators play a role in these processes is largely unknown. Here, we report that mice lacking the cell cycle inhibitors p130 and p27 show defects in tumor neoangiogenesis, both in xenografts and spontaneously arising tumors. This defect is associated with impaired mobilization of endothelial and myelomonocytic angiogenic progenitors from the bone marrow. This article documents the role of these molecules in angiogenesis and further suggests that cell expansion and mobilization from the bone marrow of angiogenic precursors are separable events.
AB - Neoangiogenesis involves both bone marrow-derived myelomonocytic and endothelial progenitor cells as well as endothelial cells coopted from surrounding vessels. Cytokines induce these cells to proliferate, migrate, and exit the cell cycle to establish the vasculature; however, which cell cycle regulators play a role in these processes is largely unknown. Here, we report that mice lacking the cell cycle inhibitors p130 and p27 show defects in tumor neoangiogenesis, both in xenografts and spontaneously arising tumors. This defect is associated with impaired mobilization of endothelial and myelomonocytic angiogenic progenitors from the bone marrow. This article documents the role of these molecules in angiogenesis and further suggests that cell expansion and mobilization from the bone marrow of angiogenic precursors are separable events.
KW - Angiogenesis
KW - Cyclin-dependent kinase inhibitors
KW - Stem cell
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U2 - 10.1073/pnas.0405823102
DO - 10.1073/pnas.0405823102
M3 - Article
C2 - 15867156
AN - SCOPUS:21044450038
SN - 0027-8424
VL - 102
SP - 6890
EP - 6895
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 19
ER -