P- and E-selectin-deficient mice are susceptible to cerebral ischemia- reperfusion injury

Sulpicio G. Soriano, Yanming F. Wang, Denisa D. Wagner, Paul S. Frenette

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We examined brain sections from P- and E-selectin-deficient mice (-/-) and their nontransgenic littermates (+/+) after focal cerebral ischemia and reperfusion (I/R) tissue injury. There was no difference in the subsequent infarct volume after 3 h of ischemia and 21 h of reperfusion. These data indicate that selectin-independent mechanisms mediate tissue injury after a prolonged period of transient focal ischemia.

Original languageEnglish (US)
Pages (from-to)360-364
Number of pages5
JournalBrain Research
Volume835
Issue number2
DOIs
StatePublished - Jul 24 1999
Externally publishedYes

Keywords

  • Cerebral ischemia
  • Selectin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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