P- and E-selectin-deficient mice are susceptible to cerebral ischemia- reperfusion injury

Sulpicio G. Soriano; Yanming F. Wang; Denisa D. Wagner; Paul S. Frenette

doi:10.1016/S0006-8993(99)01637-6

P- and E-selectin-deficient mice are susceptible to cerebral ischemia- reperfusion injury

Sulpicio G. Soriano, Yanming F. Wang, Denisa D. Wagner, Paul S. Frenette

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We examined brain sections from P- and E-selectin-deficient mice (-/-) and their nontransgenic littermates (+/+) after focal cerebral ischemia and reperfusion (I/R) tissue injury. There was no difference in the subsequent infarct volume after 3 h of ischemia and 21 h of reperfusion. These data indicate that selectin-independent mechanisms mediate tissue injury after a prolonged period of transient focal ischemia.

Original language	English (US)
Pages (from-to)	360-364
Number of pages	5
Journal	Brain research
Volume	835
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(99)01637-6
State	Published - Jul 24 1999
Externally published	Yes

Keywords

Cerebral ischemia
Selectin

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(99)01637-6

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title = "P- and E-selectin-deficient mice are susceptible to cerebral ischemia- reperfusion injury",

abstract = "We examined brain sections from P- and E-selectin-deficient mice (-/-) and their nontransgenic littermates (+/+) after focal cerebral ischemia and reperfusion (I/R) tissue injury. There was no difference in the subsequent infarct volume after 3 h of ischemia and 21 h of reperfusion. These data indicate that selectin-independent mechanisms mediate tissue injury after a prolonged period of transient focal ischemia.",

keywords = "Cerebral ischemia, Selectin",

author = "Soriano, {Sulpicio G.} and Wang, {Yanming F.} and Wagner, {Denisa D.} and Frenette, {Paul S.}",

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T1 - P- and E-selectin-deficient mice are susceptible to cerebral ischemia- reperfusion injury

AU - Soriano, Sulpicio G.

AU - Wang, Yanming F.

AU - Wagner, Denisa D.

AU - Frenette, Paul S.

N1 - Funding Information: These studies were supported by the William Randolph Hearst Fund (S.G.S.).

PY - 1999/7/24

Y1 - 1999/7/24

N2 - We examined brain sections from P- and E-selectin-deficient mice (-/-) and their nontransgenic littermates (+/+) after focal cerebral ischemia and reperfusion (I/R) tissue injury. There was no difference in the subsequent infarct volume after 3 h of ischemia and 21 h of reperfusion. These data indicate that selectin-independent mechanisms mediate tissue injury after a prolonged period of transient focal ischemia.

AB - We examined brain sections from P- and E-selectin-deficient mice (-/-) and their nontransgenic littermates (+/+) after focal cerebral ischemia and reperfusion (I/R) tissue injury. There was no difference in the subsequent infarct volume after 3 h of ischemia and 21 h of reperfusion. These data indicate that selectin-independent mechanisms mediate tissue injury after a prolonged period of transient focal ischemia.

KW - Cerebral ischemia

KW - Selectin

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EP - 364

JO - Brain research

JF - Brain research

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ER -

P- and E-selectin-deficient mice are susceptible to cerebral ischemia- reperfusion injury

Abstract

Keywords

ASJC Scopus subject areas

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