TY - JOUR
T1 - Oxytocin infusion reduces repetitive behaviors in adults with autistic and asperger’s disorders
AU - Hollander, Eric
AU - Novotny, Sherie
AU - Hanratty, Margaret
AU - Yaffe, Rona
AU - DeCaria, Concetta M.
AU - Aronowitz, Bonnie R.
AU - Mosovich, Serge
N1 - Funding Information:
Supported in part by grants from the Seaver Foundation, National Alliance for Research on Schizophrenia and Depression, Cure Autism Now, National Alliance for Autism Research and Grant 5 MO1 RR00071 for the Mount Sinai General Clinical Research Center from the National Center for Research Resources, National Institutes of Health.
PY - 2003/1
Y1 - 2003/1
N2 - Autism is a neurodevelopmentaldisorder characterized by dysfunction in three core behavioraldomains: repetitive behaviors, social deficits, and language abnormalities. There is evidence that abnormalities exist in peptide systems, particularly the oxytocin system, inautism spectrum patients. Furthermore, oxytocin and the closely related peptide vasopressin are known to play a role in socialandrepetitive behaviors. This study examined the impact of oxytocin on repetitive behaviors in 15 adults with autism or Asperger's disordervia randomized double-blind oxytocin and placebo challenges. The primary outcome measure was an instrument rating six repetitivebehaviors: need to know, repeating, ordering, need to tell/ask, self-injury, and touching. Patients with autism spectrum disorders showed asignificant reduction in repetitive behaviors following oxytocin infusion in comparison to placebo infusion. Repetitive behavior in autismspectrum disorders may be related to abnormalities in the oxytocin system, and may be partially ameliorated by synthetic oxytocininfusion.
AB - Autism is a neurodevelopmentaldisorder characterized by dysfunction in three core behavioraldomains: repetitive behaviors, social deficits, and language abnormalities. There is evidence that abnormalities exist in peptide systems, particularly the oxytocin system, inautism spectrum patients. Furthermore, oxytocin and the closely related peptide vasopressin are known to play a role in socialandrepetitive behaviors. This study examined the impact of oxytocin on repetitive behaviors in 15 adults with autism or Asperger's disordervia randomized double-blind oxytocin and placebo challenges. The primary outcome measure was an instrument rating six repetitivebehaviors: need to know, repeating, ordering, need to tell/ask, self-injury, and touching. Patients with autism spectrum disorders showed asignificant reduction in repetitive behaviors following oxytocin infusion in comparison to placebo infusion. Repetitive behavior in autismspectrum disorders may be related to abnormalities in the oxytocin system, and may be partially ameliorated by synthetic oxytocininfusion.
KW - Asperger's disorder
KW - Autism
KW - Obsessive-compulsive behaviors
KW - Oxytocin
KW - Peptide
UR - http://www.scopus.com/inward/record.url?scp=0037209159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037209159&partnerID=8YFLogxK
U2 - 10.1038/sj.npp.1300021
DO - 10.1038/sj.npp.1300021
M3 - Article
C2 - 12496956
AN - SCOPUS:0037209159
SN - 0893-133X
VL - 28
SP - 193
EP - 198
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 1
ER -