Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders.

Eric Hollander, Sherie Novotny, Margaret Hanratty, Rona Yaffe, Concetta M. DeCaria, Bonnie R. Aronowitz, Serge Mosovich

Research output: Contribution to journalArticle

434 Citations (Scopus)

Abstract

Autism is a neurodevelopmental disorder characterized by dysfunction in three core behavioral domains: repetitive behaviors, social deficits, and language abnormalities. There is evidence that abnormalities exist in peptide systems, particularly the oxytocin system, in autism spectrum patients. Furthermore, oxytocin and the closely related peptide vasopressin are known to play a role in social and repetitive behaviors. This study examined the impact of oxytocin on repetitive behaviors in 15 adults with autism or Asperger's disorder via randomized double-blind oxytocin and placebo challenges. The primary outcome measure was an instrument rating six repetitive behaviors: need to know, repeating, ordering, need to tell/ask, self-injury, and touching. Patients with autism spectrum disorders showed a significant reduction in repetitive behaviors following oxytocin infusion in comparison to placebo infusion. Repetitive behavior in autism spectrum disorders may be related to abnormalities in the oxytocin system, and may be partially ameliorated by synthetic oxytocin infusion.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalNeuropsychopharmacology
Volume28
Issue number1
StatePublished - Jan 2003
Externally publishedYes

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Asperger Syndrome
Oxytocin
Autistic Disorder
Placebos
Peptides
Vasopressins
Language
Outcome Assessment (Health Care)
Wounds and Injuries

ASJC Scopus subject areas

  • Pharmacology

Cite this

Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003). Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders. Neuropsychopharmacology, 28(1), 193-198.

Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders. / Hollander, Eric; Novotny, Sherie; Hanratty, Margaret; Yaffe, Rona; DeCaria, Concetta M.; Aronowitz, Bonnie R.; Mosovich, Serge.

In: Neuropsychopharmacology, Vol. 28, No. 1, 01.2003, p. 193-198.

Research output: Contribution to journalArticle

Hollander, E, Novotny, S, Hanratty, M, Yaffe, R, DeCaria, CM, Aronowitz, BR & Mosovich, S 2003, 'Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders.', Neuropsychopharmacology, vol. 28, no. 1, pp. 193-198.
Hollander E, Novotny S, Hanratty M, Yaffe R, DeCaria CM, Aronowitz BR et al. Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders. Neuropsychopharmacology. 2003 Jan;28(1):193-198.
Hollander, Eric ; Novotny, Sherie ; Hanratty, Margaret ; Yaffe, Rona ; DeCaria, Concetta M. ; Aronowitz, Bonnie R. ; Mosovich, Serge. / Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders. In: Neuropsychopharmacology. 2003 ; Vol. 28, No. 1. pp. 193-198.
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