Oxytocin Increases Retention of Social Cognition in Autism

Eric Hollander, Jennifer Bartz, William Chaplin, Ann Phillips, Jennifer Sumner, Latha Soorya, Evdokia Anagnostou, Stacey Wasserman

Research output: Contribution to journalArticle

503 Citations (Scopus)

Abstract

Background: Oxytocin dysfunction might contribute to the development of social deficits in autism, a core symptom domain and potential target for intervention. This study explored the effect of intravenous oxytocin administration on the retention of social information in autism. Methods: Oxytocin and placebo challenges were administered to 15 adult subjects diagnosed with autism or Asperger's disorder, and comprehension of affective speech (happy, indifferent, angry, and sad) in neutral content sentences was tested. Results: All subjects showed improvements in affective speech comprehension from pre- to post-infusion; however, whereas those who received placebo first tended to revert to baseline after a delay, those who received oxytocin first retained the ability to accurately assign emotional significance to speech intonation on the speech comprehension task. Conclusions: These results are consistent with studies linking oxytocin to social recognition in rodents as well as studies linking oxytocin to prosocial behavior in humans and suggest that oxytocin might facilitate social information processing in those with autism. These findings also provide preliminary support for the use of oxytocin in the treatment of autism.

Original languageEnglish (US)
Pages (from-to)498-503
Number of pages6
JournalBiological Psychiatry
Volume61
Issue number4
DOIs
StatePublished - Feb 15 2007
Externally publishedYes

Fingerprint

Oxytocin
Autistic Disorder
Cognition
Placebos
Asperger Syndrome
Aptitude
Retention (Psychology)
Automatic Data Processing
Intravenous Administration
Rodentia

Keywords

  • Affective speech
  • autism
  • neuropeptide
  • oxytocin
  • social cognition

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., ... Wasserman, S. (2007). Oxytocin Increases Retention of Social Cognition in Autism. Biological Psychiatry, 61(4), 498-503. https://doi.org/10.1016/j.biopsych.2006.05.030

Oxytocin Increases Retention of Social Cognition in Autism. / Hollander, Eric; Bartz, Jennifer; Chaplin, William; Phillips, Ann; Sumner, Jennifer; Soorya, Latha; Anagnostou, Evdokia; Wasserman, Stacey.

In: Biological Psychiatry, Vol. 61, No. 4, 15.02.2007, p. 498-503.

Research output: Contribution to journalArticle

Hollander, E, Bartz, J, Chaplin, W, Phillips, A, Sumner, J, Soorya, L, Anagnostou, E & Wasserman, S 2007, 'Oxytocin Increases Retention of Social Cognition in Autism', Biological Psychiatry, vol. 61, no. 4, pp. 498-503. https://doi.org/10.1016/j.biopsych.2006.05.030
Hollander E, Bartz J, Chaplin W, Phillips A, Sumner J, Soorya L et al. Oxytocin Increases Retention of Social Cognition in Autism. Biological Psychiatry. 2007 Feb 15;61(4):498-503. https://doi.org/10.1016/j.biopsych.2006.05.030
Hollander, Eric ; Bartz, Jennifer ; Chaplin, William ; Phillips, Ann ; Sumner, Jennifer ; Soorya, Latha ; Anagnostou, Evdokia ; Wasserman, Stacey. / Oxytocin Increases Retention of Social Cognition in Autism. In: Biological Psychiatry. 2007 ; Vol. 61, No. 4. pp. 498-503.
@article{efe426590d8c4648aa26d29f92c061aa,
title = "Oxytocin Increases Retention of Social Cognition in Autism",
abstract = "Background: Oxytocin dysfunction might contribute to the development of social deficits in autism, a core symptom domain and potential target for intervention. This study explored the effect of intravenous oxytocin administration on the retention of social information in autism. Methods: Oxytocin and placebo challenges were administered to 15 adult subjects diagnosed with autism or Asperger's disorder, and comprehension of affective speech (happy, indifferent, angry, and sad) in neutral content sentences was tested. Results: All subjects showed improvements in affective speech comprehension from pre- to post-infusion; however, whereas those who received placebo first tended to revert to baseline after a delay, those who received oxytocin first retained the ability to accurately assign emotional significance to speech intonation on the speech comprehension task. Conclusions: These results are consistent with studies linking oxytocin to social recognition in rodents as well as studies linking oxytocin to prosocial behavior in humans and suggest that oxytocin might facilitate social information processing in those with autism. These findings also provide preliminary support for the use of oxytocin in the treatment of autism.",
keywords = "Affective speech, autism, neuropeptide, oxytocin, social cognition",
author = "Eric Hollander and Jennifer Bartz and William Chaplin and Ann Phillips and Jennifer Sumner and Latha Soorya and Evdokia Anagnostou and Stacey Wasserman",
year = "2007",
month = "2",
day = "15",
doi = "10.1016/j.biopsych.2006.05.030",
language = "English (US)",
volume = "61",
pages = "498--503",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Oxytocin Increases Retention of Social Cognition in Autism

AU - Hollander, Eric

AU - Bartz, Jennifer

AU - Chaplin, William

AU - Phillips, Ann

AU - Sumner, Jennifer

AU - Soorya, Latha

AU - Anagnostou, Evdokia

AU - Wasserman, Stacey

PY - 2007/2/15

Y1 - 2007/2/15

N2 - Background: Oxytocin dysfunction might contribute to the development of social deficits in autism, a core symptom domain and potential target for intervention. This study explored the effect of intravenous oxytocin administration on the retention of social information in autism. Methods: Oxytocin and placebo challenges were administered to 15 adult subjects diagnosed with autism or Asperger's disorder, and comprehension of affective speech (happy, indifferent, angry, and sad) in neutral content sentences was tested. Results: All subjects showed improvements in affective speech comprehension from pre- to post-infusion; however, whereas those who received placebo first tended to revert to baseline after a delay, those who received oxytocin first retained the ability to accurately assign emotional significance to speech intonation on the speech comprehension task. Conclusions: These results are consistent with studies linking oxytocin to social recognition in rodents as well as studies linking oxytocin to prosocial behavior in humans and suggest that oxytocin might facilitate social information processing in those with autism. These findings also provide preliminary support for the use of oxytocin in the treatment of autism.

AB - Background: Oxytocin dysfunction might contribute to the development of social deficits in autism, a core symptom domain and potential target for intervention. This study explored the effect of intravenous oxytocin administration on the retention of social information in autism. Methods: Oxytocin and placebo challenges were administered to 15 adult subjects diagnosed with autism or Asperger's disorder, and comprehension of affective speech (happy, indifferent, angry, and sad) in neutral content sentences was tested. Results: All subjects showed improvements in affective speech comprehension from pre- to post-infusion; however, whereas those who received placebo first tended to revert to baseline after a delay, those who received oxytocin first retained the ability to accurately assign emotional significance to speech intonation on the speech comprehension task. Conclusions: These results are consistent with studies linking oxytocin to social recognition in rodents as well as studies linking oxytocin to prosocial behavior in humans and suggest that oxytocin might facilitate social information processing in those with autism. These findings also provide preliminary support for the use of oxytocin in the treatment of autism.

KW - Affective speech

KW - autism

KW - neuropeptide

KW - oxytocin

KW - social cognition

UR - http://www.scopus.com/inward/record.url?scp=33846624633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846624633&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2006.05.030

DO - 10.1016/j.biopsych.2006.05.030

M3 - Article

C2 - 16904652

AN - SCOPUS:33846624633

VL - 61

SP - 498

EP - 503

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 4

ER -