Oxytocin and autism

Joshua J. Green, Bonnie Taylor, Eric Hollander

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Introduction: Over the past three decades, growing research has implicated an association between the peptide hormone oxytocin (OT) and autism spectrum disorders (ASD) due to the increasingly documented involvement of OT in the regulation of social and repetitive behaviors (Modahl et al., 1992; Panksepp, 1992; Waterhouse et al., 1996; McCarthy and Altemus, 1997; Insel et al., 1999; Hollander et al., 2003; Lim et al., 2005; Hollander and Bartz, 2006; Carter, 2007; Bartz and Hollander, 2008; Guastella et al., 2008; Gregory et al., 2009; Guastella et al., 2010). In this chapter, we review research to date that has investigated the relationship between OT and the presentation or regulation of several key deficits associated with ASD. First, we provide an overview of ASD and of OT, followed by a brief review of the current theories surrounding the etiology of the disorder. Next, we review genetic research of the oxytocin receptor gene (OTR) followed by an overview of experimental therapeutic research involving the administration of OT in individuals with ASD. Finally, suggestions for directions that future research should address are discussed. Of note, only minimal animal and translational research is reviewed, as it can be found discussed at length elsewhere in the present volume. Autism spectrum disorder ASD refers to a group of neurodevelopmental disorders (autistic disorder, Asperger Syndrome and pervasive developmental disorder not otherwise specified) characterized by deficits within three core symptom domains: social interaction, speech and communication, and repetitive or compulsive behaviors with restricted interests. Formal DSM-IV diagnostic criteria for autistic disorder can be found in Textbox 20.1.

Original languageEnglish (US)
Title of host publicationOxytocin, Vasopressin, and Related Peptides in the Regulation of Behavior
PublisherCambridge University Press
Pages367-378
Number of pages12
ISBN (Print)9781139017855, 9780521190350
DOIs
StatePublished - Jan 1 2011

Fingerprint

oxytocin
Oxytocin
Autistic Disorder
Compulsive Behavior
Asperger Syndrome
Oxytocin Receptors
Therapeutic Human Experimentation
Genetic Research
Translational Medical Research
Peptide Hormones
Interpersonal Relations
Research
peptide hormones
Diagnostic and Statistical Manual of Mental Disorders
Autism Spectrum Disorder
autism
Communication
animal communication
signs and symptoms (animals and humans)
etiology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Green, J. J., Taylor, B., & Hollander, E. (2011). Oxytocin and autism. In Oxytocin, Vasopressin, and Related Peptides in the Regulation of Behavior (pp. 367-378). Cambridge University Press. https://doi.org/10.1017/CBO9781139017855.024

Oxytocin and autism. / Green, Joshua J.; Taylor, Bonnie; Hollander, Eric.

Oxytocin, Vasopressin, and Related Peptides in the Regulation of Behavior. Cambridge University Press, 2011. p. 367-378.

Research output: Chapter in Book/Report/Conference proceedingChapter

Green, JJ, Taylor, B & Hollander, E 2011, Oxytocin and autism. in Oxytocin, Vasopressin, and Related Peptides in the Regulation of Behavior. Cambridge University Press, pp. 367-378. https://doi.org/10.1017/CBO9781139017855.024
Green JJ, Taylor B, Hollander E. Oxytocin and autism. In Oxytocin, Vasopressin, and Related Peptides in the Regulation of Behavior. Cambridge University Press. 2011. p. 367-378 https://doi.org/10.1017/CBO9781139017855.024
Green, Joshua J. ; Taylor, Bonnie ; Hollander, Eric. / Oxytocin and autism. Oxytocin, Vasopressin, and Related Peptides in the Regulation of Behavior. Cambridge University Press, 2011. pp. 367-378
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