Oxygen supplementation and cardiac-autonomic modulation in COPD

Matthew N. Bartels, J. M. Gonzalez, W. Kim, R. E. De Meersman

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Study objectives: Patients with COPD have an increased sympathetic modulation and reduced baroreflex sensitivity (BRS). Therefore, we studied the effects of breathing 31% supplemental oxygen (SuppO2) on autonomic modulation in a group of COPD patients. Design: We measured autonomic modulation before and during the administration of SuppO2 on 51 patients with COPD using time-frequency analysis of R-R intervals and BP before and after intervention. This was done via a counterbalanced crossover design. The BRS index was determined using the sequence method. Results: Significant differences were seen in oxygen saturation levels following breathing with SuppO2 ([mean ± SD] 96.4 ± 1.5%) when compared to those seen after breathing with compressed air (CA) (92.8 ± 2.9%; p < 0.0001). Significant increases were seen in the natural log-transformed high-frequency modulation (HFln) (SuppO2, 10.8 ± 1.3 natural logarithm [ln] ms2/Hz; CA, 10.6 ± 1.3 ln ms2/Hz; p < 0.028) and BRS (SuppO2, 3.3 ± 2.2 ms/mm Hg; CA, 2.8 ± 1.8 ms/mm Hg) following the supplemental oxygen treatment (p < 0.015). The low-frequency/high-frequency ratio of heart rate variability revealed significant differences between the two treatments (SuppO2, 2.7 ± 1.2; CA, 3.1 ± 1.3; p < 0.008). The analysis of BP variability data revealed significant decreases in the HFln (CA, 6.9 ± 1.0 mm Hg2/Hz; SuppO2, 6.5 ± 1.2 mm Hg2/Hz; p < 0.0001). Hemodynamic data also revealed a decrease in mean heart rate after breathing SuppO2 compared with that after breathing CA (CA, 87.3 ± 13.3 beats/min; SuppO2, 85.0 ± 12.4 beats/min; p < 0.0004). The arterial pulse pressure significantly decreased when breathing SuppO2 compared with that when breathing CA (CA, 57.2 ± 13.5 mm Hg; SuppO2, 53.3 ± 13.0 mm Hg; p < 0.0023). Conclusion: Oxygen supplementation in COPD patients significantly and favorably alters autonomic modulation.

Original languageEnglish (US)
Pages (from-to)691-696
Number of pages6
JournalChest
Volume118
Issue number3
StatePublished - 2000
Externally publishedYes

Fingerprint

Compressed Air
Chronic Obstructive Pulmonary Disease
Oxygen
Respiration
Baroreflex
Heart Rate
Cross-Over Studies
Arterial Pressure
Hemodynamics
Blood Pressure

Keywords

  • Autonomic modulation
  • Baroreflex sensitivity
  • Chronic obstructive lung disease
  • COPD
  • Oxygen supplementation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Bartels, M. N., Gonzalez, J. M., Kim, W., & De Meersman, R. E. (2000). Oxygen supplementation and cardiac-autonomic modulation in COPD. Chest, 118(3), 691-696.

Oxygen supplementation and cardiac-autonomic modulation in COPD. / Bartels, Matthew N.; Gonzalez, J. M.; Kim, W.; De Meersman, R. E.

In: Chest, Vol. 118, No. 3, 2000, p. 691-696.

Research output: Contribution to journalArticle

Bartels, MN, Gonzalez, JM, Kim, W & De Meersman, RE 2000, 'Oxygen supplementation and cardiac-autonomic modulation in COPD', Chest, vol. 118, no. 3, pp. 691-696.
Bartels MN, Gonzalez JM, Kim W, De Meersman RE. Oxygen supplementation and cardiac-autonomic modulation in COPD. Chest. 2000;118(3):691-696.
Bartels, Matthew N. ; Gonzalez, J. M. ; Kim, W. ; De Meersman, R. E. / Oxygen supplementation and cardiac-autonomic modulation in COPD. In: Chest. 2000 ; Vol. 118, No. 3. pp. 691-696.
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title = "Oxygen supplementation and cardiac-autonomic modulation in COPD",
abstract = "Study objectives: Patients with COPD have an increased sympathetic modulation and reduced baroreflex sensitivity (BRS). Therefore, we studied the effects of breathing 31{\%} supplemental oxygen (SuppO2) on autonomic modulation in a group of COPD patients. Design: We measured autonomic modulation before and during the administration of SuppO2 on 51 patients with COPD using time-frequency analysis of R-R intervals and BP before and after intervention. This was done via a counterbalanced crossover design. The BRS index was determined using the sequence method. Results: Significant differences were seen in oxygen saturation levels following breathing with SuppO2 ([mean ± SD] 96.4 ± 1.5{\%}) when compared to those seen after breathing with compressed air (CA) (92.8 ± 2.9{\%}; p < 0.0001). Significant increases were seen in the natural log-transformed high-frequency modulation (HFln) (SuppO2, 10.8 ± 1.3 natural logarithm [ln] ms2/Hz; CA, 10.6 ± 1.3 ln ms2/Hz; p < 0.028) and BRS (SuppO2, 3.3 ± 2.2 ms/mm Hg; CA, 2.8 ± 1.8 ms/mm Hg) following the supplemental oxygen treatment (p < 0.015). The low-frequency/high-frequency ratio of heart rate variability revealed significant differences between the two treatments (SuppO2, 2.7 ± 1.2; CA, 3.1 ± 1.3; p < 0.008). The analysis of BP variability data revealed significant decreases in the HFln (CA, 6.9 ± 1.0 mm Hg2/Hz; SuppO2, 6.5 ± 1.2 mm Hg2/Hz; p < 0.0001). Hemodynamic data also revealed a decrease in mean heart rate after breathing SuppO2 compared with that after breathing CA (CA, 87.3 ± 13.3 beats/min; SuppO2, 85.0 ± 12.4 beats/min; p < 0.0004). The arterial pulse pressure significantly decreased when breathing SuppO2 compared with that when breathing CA (CA, 57.2 ± 13.5 mm Hg; SuppO2, 53.3 ± 13.0 mm Hg; p < 0.0023). Conclusion: Oxygen supplementation in COPD patients significantly and favorably alters autonomic modulation.",
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N2 - Study objectives: Patients with COPD have an increased sympathetic modulation and reduced baroreflex sensitivity (BRS). Therefore, we studied the effects of breathing 31% supplemental oxygen (SuppO2) on autonomic modulation in a group of COPD patients. Design: We measured autonomic modulation before and during the administration of SuppO2 on 51 patients with COPD using time-frequency analysis of R-R intervals and BP before and after intervention. This was done via a counterbalanced crossover design. The BRS index was determined using the sequence method. Results: Significant differences were seen in oxygen saturation levels following breathing with SuppO2 ([mean ± SD] 96.4 ± 1.5%) when compared to those seen after breathing with compressed air (CA) (92.8 ± 2.9%; p < 0.0001). Significant increases were seen in the natural log-transformed high-frequency modulation (HFln) (SuppO2, 10.8 ± 1.3 natural logarithm [ln] ms2/Hz; CA, 10.6 ± 1.3 ln ms2/Hz; p < 0.028) and BRS (SuppO2, 3.3 ± 2.2 ms/mm Hg; CA, 2.8 ± 1.8 ms/mm Hg) following the supplemental oxygen treatment (p < 0.015). The low-frequency/high-frequency ratio of heart rate variability revealed significant differences between the two treatments (SuppO2, 2.7 ± 1.2; CA, 3.1 ± 1.3; p < 0.008). The analysis of BP variability data revealed significant decreases in the HFln (CA, 6.9 ± 1.0 mm Hg2/Hz; SuppO2, 6.5 ± 1.2 mm Hg2/Hz; p < 0.0001). Hemodynamic data also revealed a decrease in mean heart rate after breathing SuppO2 compared with that after breathing CA (CA, 87.3 ± 13.3 beats/min; SuppO2, 85.0 ± 12.4 beats/min; p < 0.0004). The arterial pulse pressure significantly decreased when breathing SuppO2 compared with that when breathing CA (CA, 57.2 ± 13.5 mm Hg; SuppO2, 53.3 ± 13.0 mm Hg; p < 0.0023). Conclusion: Oxygen supplementation in COPD patients significantly and favorably alters autonomic modulation.

AB - Study objectives: Patients with COPD have an increased sympathetic modulation and reduced baroreflex sensitivity (BRS). Therefore, we studied the effects of breathing 31% supplemental oxygen (SuppO2) on autonomic modulation in a group of COPD patients. Design: We measured autonomic modulation before and during the administration of SuppO2 on 51 patients with COPD using time-frequency analysis of R-R intervals and BP before and after intervention. This was done via a counterbalanced crossover design. The BRS index was determined using the sequence method. Results: Significant differences were seen in oxygen saturation levels following breathing with SuppO2 ([mean ± SD] 96.4 ± 1.5%) when compared to those seen after breathing with compressed air (CA) (92.8 ± 2.9%; p < 0.0001). Significant increases were seen in the natural log-transformed high-frequency modulation (HFln) (SuppO2, 10.8 ± 1.3 natural logarithm [ln] ms2/Hz; CA, 10.6 ± 1.3 ln ms2/Hz; p < 0.028) and BRS (SuppO2, 3.3 ± 2.2 ms/mm Hg; CA, 2.8 ± 1.8 ms/mm Hg) following the supplemental oxygen treatment (p < 0.015). The low-frequency/high-frequency ratio of heart rate variability revealed significant differences between the two treatments (SuppO2, 2.7 ± 1.2; CA, 3.1 ± 1.3; p < 0.008). The analysis of BP variability data revealed significant decreases in the HFln (CA, 6.9 ± 1.0 mm Hg2/Hz; SuppO2, 6.5 ± 1.2 mm Hg2/Hz; p < 0.0001). Hemodynamic data also revealed a decrease in mean heart rate after breathing SuppO2 compared with that after breathing CA (CA, 87.3 ± 13.3 beats/min; SuppO2, 85.0 ± 12.4 beats/min; p < 0.0004). The arterial pulse pressure significantly decreased when breathing SuppO2 compared with that when breathing CA (CA, 57.2 ± 13.5 mm Hg; SuppO2, 53.3 ± 13.0 mm Hg; p < 0.0023). Conclusion: Oxygen supplementation in COPD patients significantly and favorably alters autonomic modulation.

KW - Autonomic modulation

KW - Baroreflex sensitivity

KW - Chronic obstructive lung disease

KW - COPD

KW - Oxygen supplementation

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