Oxidative stress mechanisms underlying parkinson's disease-associated neurodegeneration in C. elegans

Sudipta Chakraborty, Julia Bornhorst, Thuy T. Nguyen, Michael Aschner

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Oxidative stress is thought to play a significant role in the development and progression of neurodegenerative diseases. Although it is currently considered a hallmark of such processes, the interweaving of a multitude of signaling cascades hinders complete understanding of the direct role of oxidative stress in neurodegeneration. In addition to its extensive use as an aging model, some researchers have turned to the invertebrate model Caenorhabditis elegans (C. elegans) in order to further investigate molecular mediators that either exacerbate or protect against reactive oxygen species (ROS)-mediated neurodegeneration. Due to their fully characterized genome and short life cycle, rapid generation of C. elegans genetic models can be useful to study upstream markers of oxidative stress within interconnected signaling pathways. This report will focus on the roles of C. elegans homologs for the oxidative stress-associated transcription factor Nrf2, as well as the autosomal recessive, early-onset Parkinson's disease (PD)-associated proteins Parkin, DJ-1, and PINK1, in neurodegenerative processes.

Original languageEnglish (US)
Pages (from-to)23103-23128
Number of pages26
JournalInternational Journal of Molecular Sciences
Volume14
Issue number11
DOIs
StatePublished - Nov 21 2013
Externally publishedYes

Fingerprint

Parkinson disease
Oxidative stress
Caenorhabditis elegans
Parkinson Disease
Oxidative Stress
Neurodegenerative diseases
invertebrates
Transcription factors
genome
Genetic Models
Invertebrates
Life Cycle Stages
progressions
Neurodegenerative Diseases
markers
upstream
Life cycle
Reactive Oxygen Species
cascades
Transcription Factors

Keywords

  • C. elegans
  • Dj-1
  • Neurodegeneration
  • Nrf2
  • Oxidative stress
  • Parkin
  • Parkinson's disease
  • Pink1

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Oxidative stress mechanisms underlying parkinson's disease-associated neurodegeneration in C. elegans. / Chakraborty, Sudipta; Bornhorst, Julia; Nguyen, Thuy T.; Aschner, Michael.

In: International Journal of Molecular Sciences, Vol. 14, No. 11, 21.11.2013, p. 23103-23128.

Research output: Contribution to journalArticle

Chakraborty, Sudipta ; Bornhorst, Julia ; Nguyen, Thuy T. ; Aschner, Michael. / Oxidative stress mechanisms underlying parkinson's disease-associated neurodegeneration in C. elegans. In: International Journal of Molecular Sciences. 2013 ; Vol. 14, No. 11. pp. 23103-23128.
@article{7c89fb5b53f841c789e6e088b93d485d,
title = "Oxidative stress mechanisms underlying parkinson's disease-associated neurodegeneration in C. elegans",
abstract = "Oxidative stress is thought to play a significant role in the development and progression of neurodegenerative diseases. Although it is currently considered a hallmark of such processes, the interweaving of a multitude of signaling cascades hinders complete understanding of the direct role of oxidative stress in neurodegeneration. In addition to its extensive use as an aging model, some researchers have turned to the invertebrate model Caenorhabditis elegans (C. elegans) in order to further investigate molecular mediators that either exacerbate or protect against reactive oxygen species (ROS)-mediated neurodegeneration. Due to their fully characterized genome and short life cycle, rapid generation of C. elegans genetic models can be useful to study upstream markers of oxidative stress within interconnected signaling pathways. This report will focus on the roles of C. elegans homologs for the oxidative stress-associated transcription factor Nrf2, as well as the autosomal recessive, early-onset Parkinson's disease (PD)-associated proteins Parkin, DJ-1, and PINK1, in neurodegenerative processes.",
keywords = "C. elegans, Dj-1, Neurodegeneration, Nrf2, Oxidative stress, Parkin, Parkinson's disease, Pink1",
author = "Sudipta Chakraborty and Julia Bornhorst and Nguyen, {Thuy T.} and Michael Aschner",
year = "2013",
month = "11",
day = "21",
doi = "10.3390/ijms141123103",
language = "English (US)",
volume = "14",
pages = "23103--23128",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "11",

}

TY - JOUR

T1 - Oxidative stress mechanisms underlying parkinson's disease-associated neurodegeneration in C. elegans

AU - Chakraborty, Sudipta

AU - Bornhorst, Julia

AU - Nguyen, Thuy T.

AU - Aschner, Michael

PY - 2013/11/21

Y1 - 2013/11/21

N2 - Oxidative stress is thought to play a significant role in the development and progression of neurodegenerative diseases. Although it is currently considered a hallmark of such processes, the interweaving of a multitude of signaling cascades hinders complete understanding of the direct role of oxidative stress in neurodegeneration. In addition to its extensive use as an aging model, some researchers have turned to the invertebrate model Caenorhabditis elegans (C. elegans) in order to further investigate molecular mediators that either exacerbate or protect against reactive oxygen species (ROS)-mediated neurodegeneration. Due to their fully characterized genome and short life cycle, rapid generation of C. elegans genetic models can be useful to study upstream markers of oxidative stress within interconnected signaling pathways. This report will focus on the roles of C. elegans homologs for the oxidative stress-associated transcription factor Nrf2, as well as the autosomal recessive, early-onset Parkinson's disease (PD)-associated proteins Parkin, DJ-1, and PINK1, in neurodegenerative processes.

AB - Oxidative stress is thought to play a significant role in the development and progression of neurodegenerative diseases. Although it is currently considered a hallmark of such processes, the interweaving of a multitude of signaling cascades hinders complete understanding of the direct role of oxidative stress in neurodegeneration. In addition to its extensive use as an aging model, some researchers have turned to the invertebrate model Caenorhabditis elegans (C. elegans) in order to further investigate molecular mediators that either exacerbate or protect against reactive oxygen species (ROS)-mediated neurodegeneration. Due to their fully characterized genome and short life cycle, rapid generation of C. elegans genetic models can be useful to study upstream markers of oxidative stress within interconnected signaling pathways. This report will focus on the roles of C. elegans homologs for the oxidative stress-associated transcription factor Nrf2, as well as the autosomal recessive, early-onset Parkinson's disease (PD)-associated proteins Parkin, DJ-1, and PINK1, in neurodegenerative processes.

KW - C. elegans

KW - Dj-1

KW - Neurodegeneration

KW - Nrf2

KW - Oxidative stress

KW - Parkin

KW - Parkinson's disease

KW - Pink1

UR - http://www.scopus.com/inward/record.url?scp=84888150319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888150319&partnerID=8YFLogxK

U2 - 10.3390/ijms141123103

DO - 10.3390/ijms141123103

M3 - Article

C2 - 24284401

AN - SCOPUS:84888150319

VL - 14

SP - 23103

EP - 23128

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 11

ER -