Oxidative stress, inflamm-aging and immunosenescence

Elvira S. Cannizzo, Cristina C. Clement, Ranjit Sahu, Carlo Follo, Laura Santambrogio

Research output: Contribution to journalReview articlepeer-review

220 Scopus citations


Immunosenescence is characterized by a decreased ability of the immune system to respond to foreign antigens, as well as a decreased ability to maintain tolerance to self-antigens. This results in an increased susceptibility to infection and cancer and reduced responses to vaccination [1-5].The mechanisms underlying immunosenescence comprise a series of cellular and molecular events involving alteration of several biochemical pathways and different cellular populations, and for the most part our understanding of these molecular mechanisms is still fragmentary. In this review we will focus on the process of senescence associated with oxidative stress, in particular how protein oxidation alters the functionality of immune cells and how oxidative stress contributes to a chronic inflammatory process often referred as inflamm-aging.

Original languageEnglish (US)
Pages (from-to)2313-2323
Number of pages11
JournalJournal of Proteomics
Issue number11
StatePublished - Oct 19 2011


  • Aging
  • Immune system
  • Inflammation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry


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