Oxidative Stress Indices Changes in the Hearts of Rat Pups in Response to Maternal Buprenorphine Treatment during Gestation and Lactation

Hamed Aramjoo, Shahnaz Yousefizadeh, Michael Aschner, Babak Roshanravan, Tahereh Farkhondeh, Saeed Samarghandian

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to assess the effects of Buprenorphine (BUP) on oxidative parameters in pups born to mothers exposed to the drug during gestation and lactation. Pregnant and lactating rats received BUP, 0.5 or 0.1 mg/kg subcutaneously for 21 and 28 days, respectively. At the end of the study, the pups were anesthetized, and the hearts were dissected out to measure oxidative stress indices, including the levels of Malondialdehyde (MDA), Nitric oxide (NO), Glutathione (GSH), and the activity of Superoxide dismutase (SOD). Our findings indicated that BUP did not alter MDA, NO, GSH levels, nor SOD activity in the cardiac tissue of pups exposed to this drug during the fetal period and through breast milk. We suggest performing additional studies to determine the association between BUP and oxidative modifications in cardiac tissues of pups born to mothers under BUP therapy during gestation and lactation.

Original languageEnglish (US)
JournalCardiovascular Toxicology
DOIs
StateAccepted/In press - 2021

Keywords

  • Buprenorphine
  • Gestation
  • Lactation
  • Oxidative stress parameters
  • Pup
  • Rat

ASJC Scopus subject areas

  • Molecular Biology
  • Toxicology
  • Cardiology and Cardiovascular Medicine

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