Oxidative stress defense and repair systems of the ocular lens

Lisa Ann Brennan, Rebecca S. Estrada, Marc Kantorow

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

It is well accepted that reactive oxygen species (ROS) play a critical role in many biological processes including disease and longevity. Oxidation of proteins has been linked to many disease states and even the aging process itself. This was first proposed as "The free radical theory of aging" in 1956 by Denham Harman which suggests that free radicals causes cumulative and irreversible damage to macromolecules, loss of cellular function and cell death over time directly impacting health and lifespan. Cellular damage from ROS exposure has been termed oxidative stress, which is an imbalance between cellular ROS production and the ability of the cell to regulate ROS levels and repair damage caused by ROS. This review focuses on the role of oxidative stress in the eye lens as a model for understanding the role of oxidative stress systems in age-related human disease.

Original languageEnglish (US)
Pages (from-to)141-155
Number of pages15
JournalFrontiers in Bioscience - Elite
Volume4 E
Issue number1
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Crystalline Lens
Oxidative stress
Lenses
Reactive Oxygen Species
Oxidative Stress
Repair
Free Radicals
Aging of materials
Biological Phenomena
Cell death
Macromolecules
Cell Death
Health
Oxidation
Proteins

Keywords

  • Age-related cataract
  • Antioxidant defense
  • Antioxidant enzymes
  • Chaperone proteins
  • Lens
  • Oxidative stress
  • Protein aggregation
  • Protein oxidation
  • Protein repair
  • Reactive oxygen species
  • Review

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Brennan, L. A., Estrada, R. S., & Kantorow, M. (2012). Oxidative stress defense and repair systems of the ocular lens. Frontiers in Bioscience - Elite, 4 E(1), 141-155.

Oxidative stress defense and repair systems of the ocular lens. / Brennan, Lisa Ann; Estrada, Rebecca S.; Kantorow, Marc.

In: Frontiers in Bioscience - Elite, Vol. 4 E, No. 1, 01.01.2012, p. 141-155.

Research output: Contribution to journalReview article

Brennan, LA, Estrada, RS & Kantorow, M 2012, 'Oxidative stress defense and repair systems of the ocular lens', Frontiers in Bioscience - Elite, vol. 4 E, no. 1, pp. 141-155.
Brennan LA, Estrada RS, Kantorow M. Oxidative stress defense and repair systems of the ocular lens. Frontiers in Bioscience - Elite. 2012 Jan 1;4 E(1):141-155.
Brennan, Lisa Ann ; Estrada, Rebecca S. ; Kantorow, Marc. / Oxidative stress defense and repair systems of the ocular lens. In: Frontiers in Bioscience - Elite. 2012 ; Vol. 4 E, No. 1. pp. 141-155.
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