Oxidative stress, caspase-3 activation and cleavage of ROCK-1 play an essential role in MeHg-induced cell death in primary astroglial cells

Agriculture & Biology

• caspase-3 99%
• protein kinases 77%
• cell death 75%
• cleavage (chemistry) 69%
• oxidative stress 63%
• astrocytes 28%
• guanosinetriphosphatase 26%
• cells 25%
• viability 17%
• caspase-9 17%
• toxicity 15%
• methylmercury compounds 15%
• caspases 14%
• central nervous system 11%
• apoptosis 10%
• phosphorylation 10%
• pollution 9%
• reactive oxygen species 9%
• protein synthesis 8%
• mice 6%

Medicine & Life Sciences

• rho-Associated Kinases 100%
• Protein Kinases 74%
• Caspase 3 71%
• Cell Death 61%
• Oxidative Stress 59%
• Monomeric GTP-Binding Proteins 27%
• NAD 23%
• Astrocytes 21%
• rhoA GTP-Binding Protein 18%
• Caspase 9 13%
• Blister 12%
• Caspases 11%
• Reactive Oxygen Species 9%
• Poisons 8%
• Central Nervous System 8%
• Phosphorylation 7%
• Apoptosis 7%
• Membranes 6%

Chemical Compounds

• Cell Death 86%
• Oxidative Stress 80%
• Cleavage 55%
• Protein 33%
• Environmental Contaminant 13%
• Methylmercury(.) 13%
• Effector 11%
• Reactive Oxygen Metabolite 9%
• Toxic 7%
• Reduction 4%