Biomarcadores de estrés oxidativo como indicadores de actividad en la enfermedad articular inflamatoria crónica

Translated title of the contribution: Oxidative stress biomarkers as indicator of chronic inflammatory joint diseases stage

Montserrat Feijóo, Isaac Túnez, Adela Ruiz, Inmaculada Tasset, Elisa Muñoz, Eduardo Collantes

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Objective: To evaluate the participation of oxidative stress (OS) on chronic inflammatory joint disease (CIJD), as well as its possible use as a diagnostic biomarker. Patients and methods: The study population comprised 29 patients with CIJD: 18 with rheumatoid arthritis (RA: 13 active/5 inactive); 11 with ankylosing spondylitis (AS: 7 active/4 inactive) and 13 healthy subjects. Activity of the disease was assessed by: RA patients, Disease Activity Score (DAS 28) and AS patients by means of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Oxidative stress biomarkers were determined in plasma using spectrophotometrical techniques. The statistical analysis was carried out using the SSPS statistical package. Results: Active CIJD showed a high oxidative stress characterized by increases in oxidative damage markers and a reduction in antioxidative systems, together with a higher myeloperoxidase (MPO) concentration. Inactive CIJD only showed changes in oxidized glutathione (GSSG) and reduced glutathione (GSH)/GSSG ratio levels, without changes in oxidative damage parameters or in antioxidative systems. Conclusions: Our data revealed that: i) CIJD presents with a high oxidative stress; ii) inactive CIJD shows a production of reactive species without triggering oxidative damage and maintaining red-ox homeostasis, and iii) the combination of oxidative stress biomarkers may be used as markers of active-inactive stages of CIJD.

Translated title of the contributionOxidative stress biomarkers as indicator of chronic inflammatory joint diseases stage
Original languageSpanish
Pages (from-to)91-94
Number of pages4
JournalReumatologia Clinica
Volume6
Issue number2
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

Keywords

  • Ankylosing spondylitis
  • Chronic inflammatory joint disease
  • Oxidative damage
  • Reactive oxygen species
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

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