Oxidative stress and inflammation biomarkers in the blood of patients with huntington's disease

Fernando Sánchez-López, Inmaculada Tasset, Eduardo Agüera, Montserrat Feijóo, Ricardo Fernández-Bolaños, Francisco M. Sánchez, María C. Ruiz, Antonio H. Cruz, Fé Lix Gascón, Isaac Túnez

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Objectives: Huntington's disease (HD) is a neurodegenerative disorder for which there is no effective treatment. Oxidative stress and inflammation are known to be involved in HD, but the precise relationship between the two remains unclear. The aim of this study was to analyze oxidative stress and inflammation biomarkers in blood of patients with HD with a view to identifying potential links between them. Methods: Blood samples were collected from 13 patients with HD and from 10 age- and sex-matched controls, and the following were measured: C-reactive proteins, myeloperoxidase (MPO)/white blood cell (WBC) ratio, interleukin-6 (IL-6), thioredoxin reductase-1 (TrRd-1), thioredoxin-1 (Trx-1), total nitrites (NOx), nitric oxide synthase (NOS) and nitrotyrosine. Results: Results showed that HD is associated to a reduction of TrRd-1 and Trx-1 levels in plasma and erythrocytes, and with an increase in the MPO/WBC ratio. A positive correlation was observed between global oxidative stress (GOS) and MPO/WBC. No changes were found in NOS and Nox levels with respect to controls. Conclusion: Oxidative damage may be linked to the inflammatory response in HD, via a peripheral immune response.

Original languageEnglish (US)
Pages (from-to)721-724
Number of pages4
JournalNeurological Research
Volume34
Issue number7
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

Keywords

  • Biomarkers
  • Huntington disease
  • Immune system
  • Oxidative stress

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Sánchez-López, F., Tasset, I., Agüera, E., Feijóo, M., Fernández-Bolaños, R., Sánchez, F. M., Ruiz, M. C., Cruz, A. H., Lix Gascón, F., & Túnez, I. (2012). Oxidative stress and inflammation biomarkers in the blood of patients with huntington's disease. Neurological Research, 34(7), 721-724. https://doi.org/10.1179/1743132812Y.0000000073