Oxidative stress and angiogenesis in tumor progression

Atilla Soran, Oya Andacoglu, Bennett Van Houten

Research output: Chapter in Book/Report/Conference proceedingChapter


During tumor initiation, cells often become hypoxic and under these conditions, cancer cells activate signaling pathways, which regulate metabolism, proliferation, angiogenesis and death. This adaptation of tumor cells to hypoxia contributes to the malignant phenotype and to aggressive tumor progression, and low oxygen tension in tumors is associated with increased metastasis and poor survival of patients with several forms of tumor.

Original languageEnglish (US)
Title of host publicationEndothelium
Subtitle of host publicationMolecular Aspects of Metabolic Disorders
PublisherCRC Press
Number of pages32
ISBN (Electronic)9781466582804
ISBN (Print)9781466582798
Publication statusPublished - Jan 1 2013
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Soran, A., Andacoglu, O., & Van Houten, B. (2013). Oxidative stress and angiogenesis in tumor progression. In Endothelium: Molecular Aspects of Metabolic Disorders (pp. 394-425). CRC Press. https://doi.org/10.1201/b14907