Oxidative phosphorylation as a target space for tuberculosis: Success, caution, and future directions

Gregory M. Cook, Kiel Hards, Elyse Dunn, Adam Heikal, Yoshio Nakatani, Chris Greening, Dean C. Crick, Fabio L. Fontes, Kevin Pethe, Erik Hasenoehrl, Michael Berney

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The genus Mycobacterium comprises a group of obligately aerobic bacteria that have adapted to inhabit a wide range of intracellular and extracellular environments. Fundamental to this adaptation is the ability to respire and generate energy from variable sources and to sustain metabolism in the absence of growth. The pioneering work of Brodie and colleagues on Mycobacterium phlei established much of the primary information on the electron transport chain and oxidative phosphorylation system in mycobacteria (reviewed in 1). Mycobacteria can only generate sufficient energy for growth by coupling the oxidation of electron donors derived from organic carbon catabolism (e.g., NADH, succinate, malate) to the reduction of O2 as a terminal electron acceptor. Mycobacterial genome sequencing revealed that branched pathways exist in mycobacterial species for electron transfer from many low-potential reductants, via quinol, to oxygen (Fig. 1).

Original languageEnglish (US)
Title of host publicationTuberculosis and the Tubercle Bacillus
Subtitle of host publicationSecond Edition
Publisherwiley
Pages295-316
Number of pages22
ISBN (Electronic)9781683670834
ISBN (Print)9781555819552
DOIs
StatePublished - Sep 5 2017

Keywords

  • Electron transport chain
  • Mycobacterium tuberculosis
  • Nicotinamide adenine dinucleotide
  • Oxidative phosphorylation
  • Proton motive force
  • Redox homeostasis
  • Succinate dehydrogenase

ASJC Scopus subject areas

  • Medicine(all)

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