Oxidant stress in HIV-infected women from the Women's Interagency HIV Study

Marshall J. Glesby, Donald R. Hoover, Farbod Raiszadeh, Irene Lee, Qiuhu Shi, Ginger Milne, Stephanie C. Sanchez, Wei Gao, Robert C. Kaplan, Jason D. Morrow, Kathryn Anastos

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: Oxidant stress contributes to the pathogenesis of multiple conditions and can be assessed by measuring plasma F2-isoprostane concentrations. We hypothesized that oxidant stress is associated with plasma homocysteine concentration and risk factors for atherosclerosis in HIV-infected women. Methods: We measured plasma F2-isoprostane concentrations in a cross-sectional study of 249 HIV-infected women attending the Bronx (NY, USA) site of the Women's Interagency HIV Study and assessed associations with plasma homocysteine concentration and other metabolic parameters by linear regression. Results: In multivariate analysis, hepatitis C virus (HCV) viraemia, waist circumference, homocysteine concentration and serum aspartate aminotransferase level were positively associated with log F2-isoprostane concentration (all P<0.005). There was a trend for an inverse association between log F2-isoprostane and CD4+ T-cell percentage (P=0.06). Among women with HCV infection, the FIB-4 index, an indirect marker of liver fibrosis derived from routine laboratory tests, was positively associated with log F2-isoprostane concentration. Conclusions: In this cross-sectional study of HIV-infected women, plasma F2-isoprostane concentration was positively associated with homocysteine concentration, as well as HCV infection, abdominal obesity and aspartate aminotransferase level.

Original languageEnglish (US)
Pages (from-to)763-769
Number of pages7
JournalAntiviral Therapy
Volume14
Issue number6
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Oxidant stress in HIV-infected women from the Women's Interagency HIV Study'. Together they form a unique fingerprint.

  • Cite this

    Glesby, M. J., Hoover, D. R., Raiszadeh, F., Lee, I., Shi, Q., Milne, G., Sanchez, S. C., Gao, W., Kaplan, R. C., Morrow, J. D., & Anastos, K. (2009). Oxidant stress in HIV-infected women from the Women's Interagency HIV Study. Antiviral Therapy, 14(6), 763-769. https://doi.org/10.3851/IMP1290