Oxandrolone enhances hepatic ketogenesis in adult Men

Gloria Lena Vega, Jacob J. Clarenbach, Fredrick Dunn, Scott M. Grundy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Immediate administration of oxandrolone markedly increases hepatic lipase activity and reduces levels of plasma high-density lipoprotein. Rationale for the study: We postulated that oxandrolone should increase hepatic lipase and that the nonesterified fatty acids generated would enhance hepatic ketogenesis during an extended fat tolerance test. Main Results: Eighteen men participated in the study using short-term administration of oxandrolone (10 mg/d) over a week. Subjects had evaluation of hepatic ketogenesis at baseline and after 7 days of administration of oxandrolone. Ketogenesis was assessed by measuring plasma levels of 3-hydroxybutyrate during a fat tolerance test. Oxandrolone increased fasting levels of 3-hydroxybutyrate by 70%, and increased the area under the curve during an FFT by 53% above pretreatment levels without affecting the areas under the curve for non-esterified fatty acids, glycerol, or triglycerides. Fasting 3-hydroxybutyrate levels correlated with nonesterified fatty acids and with triglycerides; however, there were no significant correlations with any other parameter. Conclusions: This study shows that short-term administration of oxandrolone results in marked increases in hepatic ketogenesis. This finding is consistent with an increased influx of fatty acids into the liver secondary to lipoprotein lipolysis by increased hepatic lipase. However, the possibility cannot be ruled out that oxandrolone acts directly in the liver to stimulate fatty acid oxidation. Therefore, the observation of increased ketogenesis will require further studies to determine the molecular basis of the response.

Original languageEnglish (US)
Pages (from-to)920-924
Number of pages5
JournalJournal of Investigative Medicine
Volume56
Issue number7
StatePublished - Oct 2008
Externally publishedYes

Fingerprint

Oxandrolone
Liver
3-Hydroxybutyric Acid
Lipase
Fatty Acids
Nonesterified Fatty Acids
Triglycerides
Area Under Curve
Fats
Fasting
Plasmas
HDL Lipoproteins
Lipolysis
Fast Fourier transforms
Glycerol
Lipoproteins
Observation
Oxidation

Keywords

  • 3-hydroxybutyrate
  • Hepatic lipase
  • Nonesterified fatty acids
  • Steroids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Oxandrolone enhances hepatic ketogenesis in adult Men. / Vega, Gloria Lena; Clarenbach, Jacob J.; Dunn, Fredrick; Grundy, Scott M.

In: Journal of Investigative Medicine, Vol. 56, No. 7, 10.2008, p. 920-924.

Research output: Contribution to journalArticle

Vega, GL, Clarenbach, JJ, Dunn, F & Grundy, SM 2008, 'Oxandrolone enhances hepatic ketogenesis in adult Men', Journal of Investigative Medicine, vol. 56, no. 7, pp. 920-924.
Vega, Gloria Lena ; Clarenbach, Jacob J. ; Dunn, Fredrick ; Grundy, Scott M. / Oxandrolone enhances hepatic ketogenesis in adult Men. In: Journal of Investigative Medicine. 2008 ; Vol. 56, No. 7. pp. 920-924.
@article{c49e7ff0f01546cd90a8086da1ca46d4,
title = "Oxandrolone enhances hepatic ketogenesis in adult Men",
abstract = "Background: Immediate administration of oxandrolone markedly increases hepatic lipase activity and reduces levels of plasma high-density lipoprotein. Rationale for the study: We postulated that oxandrolone should increase hepatic lipase and that the nonesterified fatty acids generated would enhance hepatic ketogenesis during an extended fat tolerance test. Main Results: Eighteen men participated in the study using short-term administration of oxandrolone (10 mg/d) over a week. Subjects had evaluation of hepatic ketogenesis at baseline and after 7 days of administration of oxandrolone. Ketogenesis was assessed by measuring plasma levels of 3-hydroxybutyrate during a fat tolerance test. Oxandrolone increased fasting levels of 3-hydroxybutyrate by 70{\%}, and increased the area under the curve during an FFT by 53{\%} above pretreatment levels without affecting the areas under the curve for non-esterified fatty acids, glycerol, or triglycerides. Fasting 3-hydroxybutyrate levels correlated with nonesterified fatty acids and with triglycerides; however, there were no significant correlations with any other parameter. Conclusions: This study shows that short-term administration of oxandrolone results in marked increases in hepatic ketogenesis. This finding is consistent with an increased influx of fatty acids into the liver secondary to lipoprotein lipolysis by increased hepatic lipase. However, the possibility cannot be ruled out that oxandrolone acts directly in the liver to stimulate fatty acid oxidation. Therefore, the observation of increased ketogenesis will require further studies to determine the molecular basis of the response.",
keywords = "3-hydroxybutyrate, Hepatic lipase, Nonesterified fatty acids, Steroids",
author = "Vega, {Gloria Lena} and Clarenbach, {Jacob J.} and Fredrick Dunn and Grundy, {Scott M.}",
year = "2008",
month = "10",
language = "English (US)",
volume = "56",
pages = "920--924",
journal = "Journal of Investigative Medicine",
issn = "1081-5589",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Oxandrolone enhances hepatic ketogenesis in adult Men

AU - Vega, Gloria Lena

AU - Clarenbach, Jacob J.

AU - Dunn, Fredrick

AU - Grundy, Scott M.

PY - 2008/10

Y1 - 2008/10

N2 - Background: Immediate administration of oxandrolone markedly increases hepatic lipase activity and reduces levels of plasma high-density lipoprotein. Rationale for the study: We postulated that oxandrolone should increase hepatic lipase and that the nonesterified fatty acids generated would enhance hepatic ketogenesis during an extended fat tolerance test. Main Results: Eighteen men participated in the study using short-term administration of oxandrolone (10 mg/d) over a week. Subjects had evaluation of hepatic ketogenesis at baseline and after 7 days of administration of oxandrolone. Ketogenesis was assessed by measuring plasma levels of 3-hydroxybutyrate during a fat tolerance test. Oxandrolone increased fasting levels of 3-hydroxybutyrate by 70%, and increased the area under the curve during an FFT by 53% above pretreatment levels without affecting the areas under the curve for non-esterified fatty acids, glycerol, or triglycerides. Fasting 3-hydroxybutyrate levels correlated with nonesterified fatty acids and with triglycerides; however, there were no significant correlations with any other parameter. Conclusions: This study shows that short-term administration of oxandrolone results in marked increases in hepatic ketogenesis. This finding is consistent with an increased influx of fatty acids into the liver secondary to lipoprotein lipolysis by increased hepatic lipase. However, the possibility cannot be ruled out that oxandrolone acts directly in the liver to stimulate fatty acid oxidation. Therefore, the observation of increased ketogenesis will require further studies to determine the molecular basis of the response.

AB - Background: Immediate administration of oxandrolone markedly increases hepatic lipase activity and reduces levels of plasma high-density lipoprotein. Rationale for the study: We postulated that oxandrolone should increase hepatic lipase and that the nonesterified fatty acids generated would enhance hepatic ketogenesis during an extended fat tolerance test. Main Results: Eighteen men participated in the study using short-term administration of oxandrolone (10 mg/d) over a week. Subjects had evaluation of hepatic ketogenesis at baseline and after 7 days of administration of oxandrolone. Ketogenesis was assessed by measuring plasma levels of 3-hydroxybutyrate during a fat tolerance test. Oxandrolone increased fasting levels of 3-hydroxybutyrate by 70%, and increased the area under the curve during an FFT by 53% above pretreatment levels without affecting the areas under the curve for non-esterified fatty acids, glycerol, or triglycerides. Fasting 3-hydroxybutyrate levels correlated with nonesterified fatty acids and with triglycerides; however, there were no significant correlations with any other parameter. Conclusions: This study shows that short-term administration of oxandrolone results in marked increases in hepatic ketogenesis. This finding is consistent with an increased influx of fatty acids into the liver secondary to lipoprotein lipolysis by increased hepatic lipase. However, the possibility cannot be ruled out that oxandrolone acts directly in the liver to stimulate fatty acid oxidation. Therefore, the observation of increased ketogenesis will require further studies to determine the molecular basis of the response.

KW - 3-hydroxybutyrate

KW - Hepatic lipase

KW - Nonesterified fatty acids

KW - Steroids

UR - http://www.scopus.com/inward/record.url?scp=58149168796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149168796&partnerID=8YFLogxK

M3 - Article

VL - 56

SP - 920

EP - 924

JO - Journal of Investigative Medicine

JF - Journal of Investigative Medicine

SN - 1081-5589

IS - 7

ER -