Overview of the findings and advances in the neurocognitive and psychosocial functioning of mild to moderate pediatric CKD: perspectives from the Chronic Kidney Disease in Children (CKiD) cohort study

Stephen R. Hooper, Rebecca J. Johnson, Arlene C. Gerson, Marc B. Lande, Shlomo Shinnar, Lyndsay A. Harshman, Amy J. Kogon, Matthew Matheson, Sharon Bartosh, Joann Carlson, Bradley A. Warady, Susan L. Furth

Research output: Contribution to journalArticlepeer-review

Abstract

The Chronic Kidney Disease in Children (CKiD) prospective cohort study was designed to address the neurocognitive, growth, cardiovascular, and disease progression of children and adolescents with mild to moderate CKD. The study has had continuous funding from NIDDK for 17 years and has contributed significant advances in pediatric CKD. The goals of this educational review are threefold: (1) to provide an overview of the neurocognitive and psychosocial studies from CKiD to date; (2) to provide best practice recommendations for those working with the neurocognitive and psychosocial aspects of pediatric CKD based on CKiD findings; and (3) to help chart future goals and directives for both research and clinical practice. This collection of 22 empirical studies has produced a number of key findings for children and adolescents with mild to moderate CKD. While various studies suggest a relatively positive presentation for this population as a whole, without evidence of significant impairment or deterioration, findings do indicate the presence of neurocognitive dysfunction, emotional-behavioral difficulties, and lower quality of life for many children with CKD. These findings support the promotion of best practices that are accompanied by additional future clinical and research initiatives with this patient population.

Original languageEnglish (US)
JournalPediatric Nephrology
DOIs
StateAccepted/In press - 2021

Keywords

  • CKiD study
  • Emotional-behavioral
  • Neurocognition
  • Pediatric CKD
  • Quality of life

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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