Over-reported peripheral neuropathy symptoms in a cohort of HIV infected and uninfected Rwandan women: The need for validated locally appropriate questionnaires

David K. Tumusiime, Emmanuel Musabeyezu, Eugene Mutimurah, Donald R. Hoover, Qiuhu Shi, Emmanuel Rudakemwa, Victorien Ndacyayisenga, Jean Claude Dusingize, Jean D Amour Sinayobye, Aimee Stewart, Francois W D Venter, Kathryn Anastos

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Peripheral neuropathy symptoms (PNS) are commonly manifested in HIV-infected (HIV+) individuals, although data are limited on the prevalence and predictors of PNS in HIV+ patients from sub-Saharan Africa. Objective: To determine the prevalence and predictors of PNS in HIV+ and HIV-uninfected (HIV-) Rwandan women. Methods: Data were analysed from 936 (710 HIV+ and 226 HIV-) women from the Rwanda Women Interassociation Study and Assessment (RWISA), an observational prospective cohort study investigating the effectiveness and toxicity of ART in HIV+ women. Results: Of 936 enrolled, 920 (98.3%) were included in this analysis with 44% of HIV- and 52% of the HIV+ women reporting PNS (p=0.06). CD4+ count was not associated with PNS, although there was a non-significant trend towards higher prevalence in those with lower CD4+ counts. For the HIV- women, only alcohol and co-trimoxazole use were independently associated with PNS. WHO HIV stage IV illness and albumin ≤ 3.5 were associated with PNS in HIV+ women. Conclusions: The rate of peripheral neuropathy symptoms reported in this cohort of HIV-infected African women seems implausible, and rather suggests that the screening tool for peripheral neuropathy in culturally diverse African settings be locally validated.

Original languageEnglish (US)
Pages (from-to)460-467
Number of pages8
JournalAfrican Health Sciences
Volume14
Issue number2
DOIs
StatePublished - 2014

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Peripheral Nervous System Diseases
HIV
Surveys and Questionnaires
CD4 Lymphocyte Count
Rwanda
Africa South of the Sahara
Sulfamethoxazole Drug Combination Trimethoprim
Observational Studies
Albumins

Keywords

  • HIV and Rwandan women
  • Peripheral neuropathy symptoms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Over-reported peripheral neuropathy symptoms in a cohort of HIV infected and uninfected Rwandan women : The need for validated locally appropriate questionnaires. / Tumusiime, David K.; Musabeyezu, Emmanuel; Mutimurah, Eugene; Hoover, Donald R.; Shi, Qiuhu; Rudakemwa, Emmanuel; Ndacyayisenga, Victorien; Dusingize, Jean Claude; Sinayobye, Jean D Amour; Stewart, Aimee; Venter, Francois W D; Anastos, Kathryn.

In: African Health Sciences, Vol. 14, No. 2, 2014, p. 460-467.

Research output: Contribution to journalArticle

Tumusiime, DK, Musabeyezu, E, Mutimurah, E, Hoover, DR, Shi, Q, Rudakemwa, E, Ndacyayisenga, V, Dusingize, JC, Sinayobye, JDA, Stewart, A, Venter, FWD & Anastos, K 2014, 'Over-reported peripheral neuropathy symptoms in a cohort of HIV infected and uninfected Rwandan women: The need for validated locally appropriate questionnaires', African Health Sciences, vol. 14, no. 2, pp. 460-467. https://doi.org/10.4314/ahs.v14i2.24
Tumusiime, David K. ; Musabeyezu, Emmanuel ; Mutimurah, Eugene ; Hoover, Donald R. ; Shi, Qiuhu ; Rudakemwa, Emmanuel ; Ndacyayisenga, Victorien ; Dusingize, Jean Claude ; Sinayobye, Jean D Amour ; Stewart, Aimee ; Venter, Francois W D ; Anastos, Kathryn. / Over-reported peripheral neuropathy symptoms in a cohort of HIV infected and uninfected Rwandan women : The need for validated locally appropriate questionnaires. In: African Health Sciences. 2014 ; Vol. 14, No. 2. pp. 460-467.
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T2 - The need for validated locally appropriate questionnaires

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AU - Musabeyezu, Emmanuel

AU - Mutimurah, Eugene

AU - Hoover, Donald R.

AU - Shi, Qiuhu

AU - Rudakemwa, Emmanuel

AU - Ndacyayisenga, Victorien

AU - Dusingize, Jean Claude

AU - Sinayobye, Jean D Amour

AU - Stewart, Aimee

AU - Venter, Francois W D

AU - Anastos, Kathryn

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N2 - Background: Peripheral neuropathy symptoms (PNS) are commonly manifested in HIV-infected (HIV+) individuals, although data are limited on the prevalence and predictors of PNS in HIV+ patients from sub-Saharan Africa. Objective: To determine the prevalence and predictors of PNS in HIV+ and HIV-uninfected (HIV-) Rwandan women. Methods: Data were analysed from 936 (710 HIV+ and 226 HIV-) women from the Rwanda Women Interassociation Study and Assessment (RWISA), an observational prospective cohort study investigating the effectiveness and toxicity of ART in HIV+ women. Results: Of 936 enrolled, 920 (98.3%) were included in this analysis with 44% of HIV- and 52% of the HIV+ women reporting PNS (p=0.06). CD4+ count was not associated with PNS, although there was a non-significant trend towards higher prevalence in those with lower CD4+ counts. For the HIV- women, only alcohol and co-trimoxazole use were independently associated with PNS. WHO HIV stage IV illness and albumin ≤ 3.5 were associated with PNS in HIV+ women. Conclusions: The rate of peripheral neuropathy symptoms reported in this cohort of HIV-infected African women seems implausible, and rather suggests that the screening tool for peripheral neuropathy in culturally diverse African settings be locally validated.

AB - Background: Peripheral neuropathy symptoms (PNS) are commonly manifested in HIV-infected (HIV+) individuals, although data are limited on the prevalence and predictors of PNS in HIV+ patients from sub-Saharan Africa. Objective: To determine the prevalence and predictors of PNS in HIV+ and HIV-uninfected (HIV-) Rwandan women. Methods: Data were analysed from 936 (710 HIV+ and 226 HIV-) women from the Rwanda Women Interassociation Study and Assessment (RWISA), an observational prospective cohort study investigating the effectiveness and toxicity of ART in HIV+ women. Results: Of 936 enrolled, 920 (98.3%) were included in this analysis with 44% of HIV- and 52% of the HIV+ women reporting PNS (p=0.06). CD4+ count was not associated with PNS, although there was a non-significant trend towards higher prevalence in those with lower CD4+ counts. For the HIV- women, only alcohol and co-trimoxazole use were independently associated with PNS. WHO HIV stage IV illness and albumin ≤ 3.5 were associated with PNS in HIV+ women. Conclusions: The rate of peripheral neuropathy symptoms reported in this cohort of HIV-infected African women seems implausible, and rather suggests that the screening tool for peripheral neuropathy in culturally diverse African settings be locally validated.

KW - HIV and Rwandan women

KW - Peripheral neuropathy symptoms

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