Over-reported peripheral neuropathy symptoms in a cohort of HIV infected and uninfected Rwandan women

The need for validated locally appropriate questionnaires

David K. Tumusiime, Emmanuel Musabeyezu, Eugene Mutimurah, Donald R. Hoover, Qiuhu Shi, Emmanuel Rudakemwa, Victorien Ndacyayisenga, Jean Claude Dusingize, Jean D Amour Sinayobye, Aimee Stewart, Francois W D Venter, Kathryn Anastos

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Peripheral neuropathy symptoms (PNS) are commonly manifested in HIV-infected (HIV+) individuals, although data are limited on the prevalence and predictors of PNS in HIV+ patients from sub-Saharan Africa. Objective: To determine the prevalence and predictors of PNS in HIV+ and HIV-uninfected (HIV-) Rwandan women. Methods: Data were analysed from 936 (710 HIV+ and 226 HIV-) women from the Rwanda Women Interassociation Study and Assessment (RWISA), an observational prospective cohort study investigating the effectiveness and toxicity of ART in HIV+ women. Results: Of 936 enrolled, 920 (98.3%) were included in this analysis with 44% of HIV- and 52% of the HIV+ women reporting PNS (p=0.06). CD4+ count was not associated with PNS, although there was a non-significant trend towards higher prevalence in those with lower CD4+ counts. For the HIV- women, only alcohol and co-trimoxazole use were independently associated with PNS. WHO HIV stage IV illness and albumin ≤ 3.5 were associated with PNS in HIV+ women. Conclusions: The rate of peripheral neuropathy symptoms reported in this cohort of HIV-infected African women seems implausible, and rather suggests that the screening tool for peripheral neuropathy in culturally diverse African settings be locally validated.

Original languageEnglish (US)
Pages (from-to)460-467
Number of pages8
JournalAfrican Health Sciences
Volume14
Issue number2
DOIs
StatePublished - 2014

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Peripheral Nervous System Diseases
HIV
Surveys and Questionnaires
CD4 Lymphocyte Count
Rwanda
Africa South of the Sahara
Sulfamethoxazole Drug Combination Trimethoprim
Observational Studies
Albumins

Keywords

  • HIV and Rwandan women
  • Peripheral neuropathy symptoms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Over-reported peripheral neuropathy symptoms in a cohort of HIV infected and uninfected Rwandan women : The need for validated locally appropriate questionnaires. / Tumusiime, David K.; Musabeyezu, Emmanuel; Mutimurah, Eugene; Hoover, Donald R.; Shi, Qiuhu; Rudakemwa, Emmanuel; Ndacyayisenga, Victorien; Dusingize, Jean Claude; Sinayobye, Jean D Amour; Stewart, Aimee; Venter, Francois W D; Anastos, Kathryn.

In: African Health Sciences, Vol. 14, No. 2, 2014, p. 460-467.

Research output: Contribution to journalArticle

Tumusiime, DK, Musabeyezu, E, Mutimurah, E, Hoover, DR, Shi, Q, Rudakemwa, E, Ndacyayisenga, V, Dusingize, JC, Sinayobye, JDA, Stewart, A, Venter, FWD & Anastos, K 2014, 'Over-reported peripheral neuropathy symptoms in a cohort of HIV infected and uninfected Rwandan women: The need for validated locally appropriate questionnaires', African Health Sciences, vol. 14, no. 2, pp. 460-467. https://doi.org/10.4314/ahs.v14i2.24
Tumusiime, David K. ; Musabeyezu, Emmanuel ; Mutimurah, Eugene ; Hoover, Donald R. ; Shi, Qiuhu ; Rudakemwa, Emmanuel ; Ndacyayisenga, Victorien ; Dusingize, Jean Claude ; Sinayobye, Jean D Amour ; Stewart, Aimee ; Venter, Francois W D ; Anastos, Kathryn. / Over-reported peripheral neuropathy symptoms in a cohort of HIV infected and uninfected Rwandan women : The need for validated locally appropriate questionnaires. In: African Health Sciences. 2014 ; Vol. 14, No. 2. pp. 460-467.
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AU - Mutimurah, Eugene

AU - Hoover, Donald R.

AU - Shi, Qiuhu

AU - Rudakemwa, Emmanuel

AU - Ndacyayisenga, Victorien

AU - Dusingize, Jean Claude

AU - Sinayobye, Jean D Amour

AU - Stewart, Aimee

AU - Venter, Francois W D

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N2 - Background: Peripheral neuropathy symptoms (PNS) are commonly manifested in HIV-infected (HIV+) individuals, although data are limited on the prevalence and predictors of PNS in HIV+ patients from sub-Saharan Africa. Objective: To determine the prevalence and predictors of PNS in HIV+ and HIV-uninfected (HIV-) Rwandan women. Methods: Data were analysed from 936 (710 HIV+ and 226 HIV-) women from the Rwanda Women Interassociation Study and Assessment (RWISA), an observational prospective cohort study investigating the effectiveness and toxicity of ART in HIV+ women. Results: Of 936 enrolled, 920 (98.3%) were included in this analysis with 44% of HIV- and 52% of the HIV+ women reporting PNS (p=0.06). CD4+ count was not associated with PNS, although there was a non-significant trend towards higher prevalence in those with lower CD4+ counts. For the HIV- women, only alcohol and co-trimoxazole use were independently associated with PNS. WHO HIV stage IV illness and albumin ≤ 3.5 were associated with PNS in HIV+ women. Conclusions: The rate of peripheral neuropathy symptoms reported in this cohort of HIV-infected African women seems implausible, and rather suggests that the screening tool for peripheral neuropathy in culturally diverse African settings be locally validated.

AB - Background: Peripheral neuropathy symptoms (PNS) are commonly manifested in HIV-infected (HIV+) individuals, although data are limited on the prevalence and predictors of PNS in HIV+ patients from sub-Saharan Africa. Objective: To determine the prevalence and predictors of PNS in HIV+ and HIV-uninfected (HIV-) Rwandan women. Methods: Data were analysed from 936 (710 HIV+ and 226 HIV-) women from the Rwanda Women Interassociation Study and Assessment (RWISA), an observational prospective cohort study investigating the effectiveness and toxicity of ART in HIV+ women. Results: Of 936 enrolled, 920 (98.3%) were included in this analysis with 44% of HIV- and 52% of the HIV+ women reporting PNS (p=0.06). CD4+ count was not associated with PNS, although there was a non-significant trend towards higher prevalence in those with lower CD4+ counts. For the HIV- women, only alcohol and co-trimoxazole use were independently associated with PNS. WHO HIV stage IV illness and albumin ≤ 3.5 were associated with PNS in HIV+ women. Conclusions: The rate of peripheral neuropathy symptoms reported in this cohort of HIV-infected African women seems implausible, and rather suggests that the screening tool for peripheral neuropathy in culturally diverse African settings be locally validated.

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KW - Peripheral neuropathy symptoms

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