Ovarian involvement in endometrioid adenocarcinoma of uterus

Ken Yu Lin, David S. Miller, April A. Bailey, Sajan J. Andrews, Siobhan M. Kehoe, Debra L. Richardson, Jayanthi S. Lea

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective Ovarian preservation is an option for some premenopausal patients with early stage endometrial cancer. Studies have shown that ovarian preservation in selected patients does not negatively impact survival outcomes. The objective of this study is to determine the frequency and characteristics of ovarian involvement when endometrial cancer is clinically confined to the uterus. Methods Patients with endometrioid adenocarcinoma of uterus treated at our institution between 2000 and 2013 were identified. Patients with ovarian metastasis or synchronous primary ovarian cancer were included. Patients were excluded if there was gross extrapelvic disease on examination or imaging. Results Seven hundred and fifty-nine patients were found to have endometrial cancer with the disease confined to the pelvis (stages I, II, and III). Fifteen patients (2%) had ovarian metastasis. Twenty-three patients (3%) had synchronous uterine and ovarian cancer. Most ovarian lesions (32 out of 38) were either enlarged or had abnormal appearing surface involvement. Six patients had microscopic ovarian involvement, accounting for 0.8% of the endometrial cancer patients with pelvis-confined disease. All of the patients were greater than 50 years of age. For those patients with microscopic ovarian metastasis, all had FIGO grade 3 disease, deep myometrial invasion, and extrauterine involvement of either cervix or lymph nodes. Conclusions Microscopic ovarian involvement occurred in 0.8% of patients with endometrial cancer. For premenopausal patients with endometrial cancer, normal appearing ovaries may be considered for preservation in the absence of extrauterine spread, grade 3 disease and deep myometrial invasion.

Original languageEnglish (US)
Pages (from-to)532-535
Number of pages4
JournalGynecologic Oncology
Volume138
Issue number3
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

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Endometrioid Carcinoma
Uterus
Endometrial Neoplasms
Neoplasm Metastasis
Pelvis
Ovarian Neoplasms
Uterine Neoplasms
Cervix Uteri

Keywords

  • Endometrial cancer
  • Ovarian metastasis

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

Lin, K. Y., Miller, D. S., Bailey, A. A., Andrews, S. J., Kehoe, S. M., Richardson, D. L., & Lea, J. S. (2015). Ovarian involvement in endometrioid adenocarcinoma of uterus. Gynecologic Oncology, 138(3), 532-535. https://doi.org/10.1016/j.ygyno.2015.07.012

Ovarian involvement in endometrioid adenocarcinoma of uterus. / Lin, Ken Yu; Miller, David S.; Bailey, April A.; Andrews, Sajan J.; Kehoe, Siobhan M.; Richardson, Debra L.; Lea, Jayanthi S.

In: Gynecologic Oncology, Vol. 138, No. 3, 01.09.2015, p. 532-535.

Research output: Contribution to journalArticle

Lin, KY, Miller, DS, Bailey, AA, Andrews, SJ, Kehoe, SM, Richardson, DL & Lea, JS 2015, 'Ovarian involvement in endometrioid adenocarcinoma of uterus', Gynecologic Oncology, vol. 138, no. 3, pp. 532-535. https://doi.org/10.1016/j.ygyno.2015.07.012
Lin KY, Miller DS, Bailey AA, Andrews SJ, Kehoe SM, Richardson DL et al. Ovarian involvement in endometrioid adenocarcinoma of uterus. Gynecologic Oncology. 2015 Sep 1;138(3):532-535. https://doi.org/10.1016/j.ygyno.2015.07.012
Lin, Ken Yu ; Miller, David S. ; Bailey, April A. ; Andrews, Sajan J. ; Kehoe, Siobhan M. ; Richardson, Debra L. ; Lea, Jayanthi S. / Ovarian involvement in endometrioid adenocarcinoma of uterus. In: Gynecologic Oncology. 2015 ; Vol. 138, No. 3. pp. 532-535.
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abstract = "Objective Ovarian preservation is an option for some premenopausal patients with early stage endometrial cancer. Studies have shown that ovarian preservation in selected patients does not negatively impact survival outcomes. The objective of this study is to determine the frequency and characteristics of ovarian involvement when endometrial cancer is clinically confined to the uterus. Methods Patients with endometrioid adenocarcinoma of uterus treated at our institution between 2000 and 2013 were identified. Patients with ovarian metastasis or synchronous primary ovarian cancer were included. Patients were excluded if there was gross extrapelvic disease on examination or imaging. Results Seven hundred and fifty-nine patients were found to have endometrial cancer with the disease confined to the pelvis (stages I, II, and III). Fifteen patients (2{\%}) had ovarian metastasis. Twenty-three patients (3{\%}) had synchronous uterine and ovarian cancer. Most ovarian lesions (32 out of 38) were either enlarged or had abnormal appearing surface involvement. Six patients had microscopic ovarian involvement, accounting for 0.8{\%} of the endometrial cancer patients with pelvis-confined disease. All of the patients were greater than 50 years of age. For those patients with microscopic ovarian metastasis, all had FIGO grade 3 disease, deep myometrial invasion, and extrauterine involvement of either cervix or lymph nodes. Conclusions Microscopic ovarian involvement occurred in 0.8{\%} of patients with endometrial cancer. For premenopausal patients with endometrial cancer, normal appearing ovaries may be considered for preservation in the absence of extrauterine spread, grade 3 disease and deep myometrial invasion.",
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