Outwitting evolution: Fighting drug-resistant TB, Malaria, and HIV

Daniel E. Goldberg, Robert F. Siliciano, William R. Jacobs

Research output: Contribution to journalReview article

98 Citations (Scopus)

Abstract

Although caused by vastly different pathogens, the world's three most serious infectious diseases, tuberculosis, malaria, and HIV-1 infection, share the common problem of drug resistance. The pace of drug development has been very slow for tuberculosis and malaria and rapid for HIV-1. But for each disease, resistance to most drugs has appeared quickly after the introduction of the drug. Learning how to manage and prevent resistance is a major medical challenge that requires an understanding of the evolutionary dynamics of each pathogen. This Review summarizes the similarities and differences in the evolution of drug resistance for these three pathogens.

Original languageEnglish (US)
Pages (from-to)1271-1283
Number of pages13
JournalCell
Volume148
Issue number6
DOIs
StatePublished - Mar 16 2012

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Malaria
HIV
Drug Resistance
Pathogens
HIV-1
Tuberculosis
Pharmaceutical Preparations
Disease Resistance
HIV Infections
Communicable Diseases
Learning

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Outwitting evolution : Fighting drug-resistant TB, Malaria, and HIV. / Goldberg, Daniel E.; Siliciano, Robert F.; Jacobs, William R.

In: Cell, Vol. 148, No. 6, 16.03.2012, p. 1271-1283.

Research output: Contribution to journalReview article

Goldberg, Daniel E. ; Siliciano, Robert F. ; Jacobs, William R. / Outwitting evolution : Fighting drug-resistant TB, Malaria, and HIV. In: Cell. 2012 ; Vol. 148, No. 6. pp. 1271-1283.
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