Outcomes of Radical Cystectomy for Transitional Cell Carcinoma of the Bladder

A Contemporary Series From the Bladder Cancer Research Consortium

Shahrokh F. Shariat, Pierre I. Karakiewicz, Ganesh S. Palapattu, Yair Lotan, Craig G. Rogers, Gilad E. Amiel, Amnon Vazina, Amit Gupta, Patrick J. Bastian, Arthur I. Sagalowsky, Mark P. Schoenberg, Seth P. Lerner

Research output: Contribution to journalArticle

453 Citations (Scopus)

Abstract

Purpose: We present the characteristics and outcomes of a large, contemporary, consecutive series of patients treated with radical cystectomy and pelvic lymphadenectomy for transitional cell carcinoma of the bladder. Materials and Methods: We developed a multi-institutional database and collected retrospective and prospective data on 888 consecutive patients with bladder transitional cell carcinoma who were treated with radical cystectomy and pelvic lymphadenectomy at 3 academic centers in the United States between 1984 and 2003. Results: Of the patients 25% had extravesical tumor extension with negative lymph nodes and 23% had lymph node metastasis. The rate of lymph node involvement increased with advancing pathological stage. Mean recurrence-free and bladder cancer specific survival ± SE was 58% ± 2% and 66% ± 2% at 5 years, respectively. On preoperative multivariate analysis clinical tumor stage and neoadjuvant systemic chemotherapy were associated with cancer recurrence, while more advanced age, clinical tumor stage and preoperative carcinoma in situ were associated with bladder cancer specific mortality. On postoperative multivariate analysis pathological tumor stage, lymph node metastasis, lymphovascular invasion, adjuvant radiotherapy and adjuvant chemotherapy were associated with cancer recurrence, while higher pathological tumor stage, more advanced age, lymph node metastasis, lymphovascular invasion and adjuvant radiotherapy were associated with disease specific survival. Patients with metastasis to regional lymph nodes (pT any N1-3) were at significantly higher risk for bladder cancer recurrence and death than patients with extravesical tumor extension (pT3N0), who in turn were at significantly higher risk than patients with organ confined disease (pT2 N0 or less). Conclusions: The results of this large, contemporary, multi-institutional series show that radical cystectomy and pelvic lymphadenectomy provide durable local control and disease specific survival in patients with localized invasive transitional cell carcinoma.

Original languageEnglish (US)
Pages (from-to)2414-2422
Number of pages9
JournalJournal of Urology
Volume176
Issue number6
DOIs
StatePublished - Dec 2006
Externally publishedYes

Fingerprint

Transitional Cell Carcinoma
Cystectomy
Urinary Bladder Neoplasms
Urinary Bladder
Lymph Nodes
Research
Neoplasms
Lymph Node Excision
Neoplasm Metastasis
Recurrence
Adjuvant Radiotherapy
Survival
Multivariate Analysis
Carcinoma in Situ
Adjuvant Chemotherapy
Databases
Drug Therapy
Mortality

Keywords

  • bladder
  • bladder neoplasms
  • carcinoma
  • cystectomy
  • mortality
  • transitional cell

ASJC Scopus subject areas

  • Urology

Cite this

Shariat, S. F., Karakiewicz, P. I., Palapattu, G. S., Lotan, Y., Rogers, C. G., Amiel, G. E., ... Lerner, S. P. (2006). Outcomes of Radical Cystectomy for Transitional Cell Carcinoma of the Bladder: A Contemporary Series From the Bladder Cancer Research Consortium. Journal of Urology, 176(6), 2414-2422. https://doi.org/10.1016/j.juro.2006.08.004

Outcomes of Radical Cystectomy for Transitional Cell Carcinoma of the Bladder : A Contemporary Series From the Bladder Cancer Research Consortium. / Shariat, Shahrokh F.; Karakiewicz, Pierre I.; Palapattu, Ganesh S.; Lotan, Yair; Rogers, Craig G.; Amiel, Gilad E.; Vazina, Amnon; Gupta, Amit; Bastian, Patrick J.; Sagalowsky, Arthur I.; Schoenberg, Mark P.; Lerner, Seth P.

In: Journal of Urology, Vol. 176, No. 6, 12.2006, p. 2414-2422.

Research output: Contribution to journalArticle

Shariat, SF, Karakiewicz, PI, Palapattu, GS, Lotan, Y, Rogers, CG, Amiel, GE, Vazina, A, Gupta, A, Bastian, PJ, Sagalowsky, AI, Schoenberg, MP & Lerner, SP 2006, 'Outcomes of Radical Cystectomy for Transitional Cell Carcinoma of the Bladder: A Contemporary Series From the Bladder Cancer Research Consortium', Journal of Urology, vol. 176, no. 6, pp. 2414-2422. https://doi.org/10.1016/j.juro.2006.08.004
Shariat, Shahrokh F. ; Karakiewicz, Pierre I. ; Palapattu, Ganesh S. ; Lotan, Yair ; Rogers, Craig G. ; Amiel, Gilad E. ; Vazina, Amnon ; Gupta, Amit ; Bastian, Patrick J. ; Sagalowsky, Arthur I. ; Schoenberg, Mark P. ; Lerner, Seth P. / Outcomes of Radical Cystectomy for Transitional Cell Carcinoma of the Bladder : A Contemporary Series From the Bladder Cancer Research Consortium. In: Journal of Urology. 2006 ; Vol. 176, No. 6. pp. 2414-2422.
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abstract = "Purpose: We present the characteristics and outcomes of a large, contemporary, consecutive series of patients treated with radical cystectomy and pelvic lymphadenectomy for transitional cell carcinoma of the bladder. Materials and Methods: We developed a multi-institutional database and collected retrospective and prospective data on 888 consecutive patients with bladder transitional cell carcinoma who were treated with radical cystectomy and pelvic lymphadenectomy at 3 academic centers in the United States between 1984 and 2003. Results: Of the patients 25{\%} had extravesical tumor extension with negative lymph nodes and 23{\%} had lymph node metastasis. The rate of lymph node involvement increased with advancing pathological stage. Mean recurrence-free and bladder cancer specific survival ± SE was 58{\%} ± 2{\%} and 66{\%} ± 2{\%} at 5 years, respectively. On preoperative multivariate analysis clinical tumor stage and neoadjuvant systemic chemotherapy were associated with cancer recurrence, while more advanced age, clinical tumor stage and preoperative carcinoma in situ were associated with bladder cancer specific mortality. On postoperative multivariate analysis pathological tumor stage, lymph node metastasis, lymphovascular invasion, adjuvant radiotherapy and adjuvant chemotherapy were associated with cancer recurrence, while higher pathological tumor stage, more advanced age, lymph node metastasis, lymphovascular invasion and adjuvant radiotherapy were associated with disease specific survival. Patients with metastasis to regional lymph nodes (pT any N1-3) were at significantly higher risk for bladder cancer recurrence and death than patients with extravesical tumor extension (pT3N0), who in turn were at significantly higher risk than patients with organ confined disease (pT2 N0 or less). Conclusions: The results of this large, contemporary, multi-institutional series show that radical cystectomy and pelvic lymphadenectomy provide durable local control and disease specific survival in patients with localized invasive transitional cell carcinoma.",
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AU - Amiel, Gilad E.

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