Outcomes of patients admitted with ventricular arrhythmias and sudden cardiac death in the United States

Juan F. Viles-Gonzalez, Shilpkumar Arora, Abhishek Deshmukh, Varunsiri Atti, Kanishk Agnihotri, Nileshkumar Patel, Mihir Dave, Elad Anter, Fermin Garcia, Pasquale Santangelli, Jeffrey J. Goldberger, Srinivas Dukkipati, Andre d'Avila, Andrea Natale, Luigi Di Biase

Research output: Contribution to journalArticle

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Abstract

Background: Mortality caused by ventricular arrhythmias (VAs) remains a problem of epidemic proportions. Understanding current trends on admission of VA, patient characteristics, morbidity, mortality, and health care utilization could help us improve allocation of health care resources and risk prediction. Objective: The purpose of this study was to investigate clinical outcomes of VA, including ventricular tachycardia (VT), implantable cardioverter–defibrillator (ICD) shocks, and sudden cardiac death (SCD); and to identify predictors of morbidity and mortality, patterns of utilization of ICD and VT ablation, and the impact of such metrics on overall health care utilization. Methods: From 2010–2015, we identified 290,998 VA hospitalizations, which were stratified into group 1: normal heart; group 2: ischemic heart disease (IHD); group 3: nonischemic heart disease (non-IHD); group 4: ICD shocks; and group 5: SCD (cardiac arrest without ICD shock). Results: The number of admissions for VA decreased during the study period (except for patients with SCD and ICD shock, which increased); in-hospital mortality in patients admitted with VA and SCD increased; utilization of VT ablation in patients with ICD shocks and IHD increased; ICD implantation decreased in non-IHD patients and IHD patients; and admission for SCD was the strongest predictor of in-hospital mortality, followed by patients with non-IHD, patients with ICD shocks, and all patients with a Charlson comorbidity index ≥2. Conclusion: We report a decrease in admissions for VA, decreased ICD utilization, a change in pattern of VT ablation utilization, and an increase of in-hospital mortality in SCD patients. Predictors of adverse outcomes identified in our study should be considered when developing risk models for patients undergoing risk assessment for SCD.

Original languageEnglish (US)
JournalHeart Rhythm
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Sudden Cardiac Death
Cardiac Arrhythmias
Shock
Ventricular Tachycardia
Hospital Mortality
Patient Acceptance of Health Care
Myocardial Ischemia
Heart Diseases
Mortality
Morbidity
Health Resources
Heart Arrest
Comorbidity
Hospitalization
Delivery of Health Care

Keywords

  • Ablation
  • Cardiac arrest
  • Implantable cardioverter–defibrillator
  • Sudden death
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Outcomes of patients admitted with ventricular arrhythmias and sudden cardiac death in the United States. / Viles-Gonzalez, Juan F.; Arora, Shilpkumar; Deshmukh, Abhishek; Atti, Varunsiri; Agnihotri, Kanishk; Patel, Nileshkumar; Dave, Mihir; Anter, Elad; Garcia, Fermin; Santangelli, Pasquale; Goldberger, Jeffrey J.; Dukkipati, Srinivas; d'Avila, Andre; Natale, Andrea; Di Biase, Luigi.

In: Heart Rhythm, 01.01.2018.

Research output: Contribution to journalArticle

Viles-Gonzalez, JF, Arora, S, Deshmukh, A, Atti, V, Agnihotri, K, Patel, N, Dave, M, Anter, E, Garcia, F, Santangelli, P, Goldberger, JJ, Dukkipati, S, d'Avila, A, Natale, A & Di Biase, L 2018, 'Outcomes of patients admitted with ventricular arrhythmias and sudden cardiac death in the United States', Heart Rhythm. https://doi.org/10.1016/j.hrthm.2018.09.007
Viles-Gonzalez, Juan F. ; Arora, Shilpkumar ; Deshmukh, Abhishek ; Atti, Varunsiri ; Agnihotri, Kanishk ; Patel, Nileshkumar ; Dave, Mihir ; Anter, Elad ; Garcia, Fermin ; Santangelli, Pasquale ; Goldberger, Jeffrey J. ; Dukkipati, Srinivas ; d'Avila, Andre ; Natale, Andrea ; Di Biase, Luigi. / Outcomes of patients admitted with ventricular arrhythmias and sudden cardiac death in the United States. In: Heart Rhythm. 2018.
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AU - Atti, Varunsiri

AU - Agnihotri, Kanishk

AU - Patel, Nileshkumar

AU - Dave, Mihir

AU - Anter, Elad

AU - Garcia, Fermin

AU - Santangelli, Pasquale

AU - Goldberger, Jeffrey J.

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AU - Di Biase, Luigi

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N2 - Background: Mortality caused by ventricular arrhythmias (VAs) remains a problem of epidemic proportions. Understanding current trends on admission of VA, patient characteristics, morbidity, mortality, and health care utilization could help us improve allocation of health care resources and risk prediction. Objective: The purpose of this study was to investigate clinical outcomes of VA, including ventricular tachycardia (VT), implantable cardioverter–defibrillator (ICD) shocks, and sudden cardiac death (SCD); and to identify predictors of morbidity and mortality, patterns of utilization of ICD and VT ablation, and the impact of such metrics on overall health care utilization. Methods: From 2010–2015, we identified 290,998 VA hospitalizations, which were stratified into group 1: normal heart; group 2: ischemic heart disease (IHD); group 3: nonischemic heart disease (non-IHD); group 4: ICD shocks; and group 5: SCD (cardiac arrest without ICD shock). Results: The number of admissions for VA decreased during the study period (except for patients with SCD and ICD shock, which increased); in-hospital mortality in patients admitted with VA and SCD increased; utilization of VT ablation in patients with ICD shocks and IHD increased; ICD implantation decreased in non-IHD patients and IHD patients; and admission for SCD was the strongest predictor of in-hospital mortality, followed by patients with non-IHD, patients with ICD shocks, and all patients with a Charlson comorbidity index ≥2. Conclusion: We report a decrease in admissions for VA, decreased ICD utilization, a change in pattern of VT ablation utilization, and an increase of in-hospital mortality in SCD patients. Predictors of adverse outcomes identified in our study should be considered when developing risk models for patients undergoing risk assessment for SCD.

AB - Background: Mortality caused by ventricular arrhythmias (VAs) remains a problem of epidemic proportions. Understanding current trends on admission of VA, patient characteristics, morbidity, mortality, and health care utilization could help us improve allocation of health care resources and risk prediction. Objective: The purpose of this study was to investigate clinical outcomes of VA, including ventricular tachycardia (VT), implantable cardioverter–defibrillator (ICD) shocks, and sudden cardiac death (SCD); and to identify predictors of morbidity and mortality, patterns of utilization of ICD and VT ablation, and the impact of such metrics on overall health care utilization. Methods: From 2010–2015, we identified 290,998 VA hospitalizations, which were stratified into group 1: normal heart; group 2: ischemic heart disease (IHD); group 3: nonischemic heart disease (non-IHD); group 4: ICD shocks; and group 5: SCD (cardiac arrest without ICD shock). Results: The number of admissions for VA decreased during the study period (except for patients with SCD and ICD shock, which increased); in-hospital mortality in patients admitted with VA and SCD increased; utilization of VT ablation in patients with ICD shocks and IHD increased; ICD implantation decreased in non-IHD patients and IHD patients; and admission for SCD was the strongest predictor of in-hospital mortality, followed by patients with non-IHD, patients with ICD shocks, and all patients with a Charlson comorbidity index ≥2. Conclusion: We report a decrease in admissions for VA, decreased ICD utilization, a change in pattern of VT ablation utilization, and an increase of in-hospital mortality in SCD patients. Predictors of adverse outcomes identified in our study should be considered when developing risk models for patients undergoing risk assessment for SCD.

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KW - Implantable cardioverter–defibrillator

KW - Sudden death

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