Outcomes and complications of catheter ablation for atrial fibrillation in females

Dimpi Patel, Prasant Mohanty, Luigi Di Biase, Javier E. Sanchez, Mazen H. Shaheen, J. David Burkhardt, Mohammed Bassouni, Jennifer Cummings, Yan Wang, William R. Lewis, Alberto Diaz, Rodney P. Horton, Salwa Beheiry, Richard Hongo, G. Joseph Gallinghouse, Jason D. Zagrodzky, Shane M. Bailey, Amin Al-Ahmad, Paul Wang, Robert A. SchweikertAndrea Natale

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Background: Most atrial fibrillation (AF) ablation studies have consisted predominantly of males; accordingly, there is a paucity of information on the safety and efficacy of catheter ablation in a large cohort of female AF patients. Objective: The purpose of this study was to evaluate catheter ablation for AF in female patients. Methods: From January 2005 to May 2008, 3265 females underwent pulmonary vein antrum isolation. Success rates, patient profiles, and complications were collected. Results: Approximately 16% of our population was female (P <.001). Females were older (59 ± 13 vs. 56 ± 19 years; P <.01) and had a lower prevalence of paroxysmal atrial fibrillation (PAF; 46% vs. 55%; P <.001). Females failed more antiarrhythmics (4 ± 1 vs. 2 ± 3; P = .04) and were referred later for catheter ablation (6.51 ± 7 vs. 4.85 ± 6.5 years; P = .02) than males. More females failed ablation (31.5% vs. 22.5%; P = .001) and had nonantral sites of firing than males (P <.001). Female patients had 11 (2.1%) hematomas versus 27 (0.9%) in males. Conclusions: Five times as many males underwent catheter ablation than females. Females failed more ablations possibly because of a higher prevalence of nonantral firing, non-PAF, and longer history of AF. Females had more bleeding complications than males.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalHeart Rhythm
Volume7
Issue number2
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Catheter Ablation
Atrial Fibrillation
Pulmonary Veins
Hematoma
Hemorrhage
Safety

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Female
  • gender
  • Hematoma
  • Nonantral firing
  • Pulmonary vein isolation
  • Referral patterns

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Patel, D., Mohanty, P., Di Biase, L., Sanchez, J. E., Shaheen, M. H., Burkhardt, J. D., ... Natale, A. (2010). Outcomes and complications of catheter ablation for atrial fibrillation in females. Heart Rhythm, 7(2), 167-172. https://doi.org/10.1016/j.hrthm.2009.10.025

Outcomes and complications of catheter ablation for atrial fibrillation in females. / Patel, Dimpi; Mohanty, Prasant; Di Biase, Luigi; Sanchez, Javier E.; Shaheen, Mazen H.; Burkhardt, J. David; Bassouni, Mohammed; Cummings, Jennifer; Wang, Yan; Lewis, William R.; Diaz, Alberto; Horton, Rodney P.; Beheiry, Salwa; Hongo, Richard; Gallinghouse, G. Joseph; Zagrodzky, Jason D.; Bailey, Shane M.; Al-Ahmad, Amin; Wang, Paul; Schweikert, Robert A.; Natale, Andrea.

In: Heart Rhythm, Vol. 7, No. 2, 2010, p. 167-172.

Research output: Contribution to journalArticle

Patel, D, Mohanty, P, Di Biase, L, Sanchez, JE, Shaheen, MH, Burkhardt, JD, Bassouni, M, Cummings, J, Wang, Y, Lewis, WR, Diaz, A, Horton, RP, Beheiry, S, Hongo, R, Gallinghouse, GJ, Zagrodzky, JD, Bailey, SM, Al-Ahmad, A, Wang, P, Schweikert, RA & Natale, A 2010, 'Outcomes and complications of catheter ablation for atrial fibrillation in females', Heart Rhythm, vol. 7, no. 2, pp. 167-172. https://doi.org/10.1016/j.hrthm.2009.10.025
Patel, Dimpi ; Mohanty, Prasant ; Di Biase, Luigi ; Sanchez, Javier E. ; Shaheen, Mazen H. ; Burkhardt, J. David ; Bassouni, Mohammed ; Cummings, Jennifer ; Wang, Yan ; Lewis, William R. ; Diaz, Alberto ; Horton, Rodney P. ; Beheiry, Salwa ; Hongo, Richard ; Gallinghouse, G. Joseph ; Zagrodzky, Jason D. ; Bailey, Shane M. ; Al-Ahmad, Amin ; Wang, Paul ; Schweikert, Robert A. ; Natale, Andrea. / Outcomes and complications of catheter ablation for atrial fibrillation in females. In: Heart Rhythm. 2010 ; Vol. 7, No. 2. pp. 167-172.
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abstract = "Background: Most atrial fibrillation (AF) ablation studies have consisted predominantly of males; accordingly, there is a paucity of information on the safety and efficacy of catheter ablation in a large cohort of female AF patients. Objective: The purpose of this study was to evaluate catheter ablation for AF in female patients. Methods: From January 2005 to May 2008, 3265 females underwent pulmonary vein antrum isolation. Success rates, patient profiles, and complications were collected. Results: Approximately 16{\%} of our population was female (P <.001). Females were older (59 ± 13 vs. 56 ± 19 years; P <.01) and had a lower prevalence of paroxysmal atrial fibrillation (PAF; 46{\%} vs. 55{\%}; P <.001). Females failed more antiarrhythmics (4 ± 1 vs. 2 ± 3; P = .04) and were referred later for catheter ablation (6.51 ± 7 vs. 4.85 ± 6.5 years; P = .02) than males. More females failed ablation (31.5{\%} vs. 22.5{\%}; P = .001) and had nonantral sites of firing than males (P <.001). Female patients had 11 (2.1{\%}) hematomas versus 27 (0.9{\%}) in males. Conclusions: Five times as many males underwent catheter ablation than females. Females failed more ablations possibly because of a higher prevalence of nonantral firing, non-PAF, and longer history of AF. Females had more bleeding complications than males.",
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T1 - Outcomes and complications of catheter ablation for atrial fibrillation in females

AU - Patel, Dimpi

AU - Mohanty, Prasant

AU - Di Biase, Luigi

AU - Sanchez, Javier E.

AU - Shaheen, Mazen H.

AU - Burkhardt, J. David

AU - Bassouni, Mohammed

AU - Cummings, Jennifer

AU - Wang, Yan

AU - Lewis, William R.

AU - Diaz, Alberto

AU - Horton, Rodney P.

AU - Beheiry, Salwa

AU - Hongo, Richard

AU - Gallinghouse, G. Joseph

AU - Zagrodzky, Jason D.

AU - Bailey, Shane M.

AU - Al-Ahmad, Amin

AU - Wang, Paul

AU - Schweikert, Robert A.

AU - Natale, Andrea

PY - 2010

Y1 - 2010

N2 - Background: Most atrial fibrillation (AF) ablation studies have consisted predominantly of males; accordingly, there is a paucity of information on the safety and efficacy of catheter ablation in a large cohort of female AF patients. Objective: The purpose of this study was to evaluate catheter ablation for AF in female patients. Methods: From January 2005 to May 2008, 3265 females underwent pulmonary vein antrum isolation. Success rates, patient profiles, and complications were collected. Results: Approximately 16% of our population was female (P <.001). Females were older (59 ± 13 vs. 56 ± 19 years; P <.01) and had a lower prevalence of paroxysmal atrial fibrillation (PAF; 46% vs. 55%; P <.001). Females failed more antiarrhythmics (4 ± 1 vs. 2 ± 3; P = .04) and were referred later for catheter ablation (6.51 ± 7 vs. 4.85 ± 6.5 years; P = .02) than males. More females failed ablation (31.5% vs. 22.5%; P = .001) and had nonantral sites of firing than males (P <.001). Female patients had 11 (2.1%) hematomas versus 27 (0.9%) in males. Conclusions: Five times as many males underwent catheter ablation than females. Females failed more ablations possibly because of a higher prevalence of nonantral firing, non-PAF, and longer history of AF. Females had more bleeding complications than males.

AB - Background: Most atrial fibrillation (AF) ablation studies have consisted predominantly of males; accordingly, there is a paucity of information on the safety and efficacy of catheter ablation in a large cohort of female AF patients. Objective: The purpose of this study was to evaluate catheter ablation for AF in female patients. Methods: From January 2005 to May 2008, 3265 females underwent pulmonary vein antrum isolation. Success rates, patient profiles, and complications were collected. Results: Approximately 16% of our population was female (P <.001). Females were older (59 ± 13 vs. 56 ± 19 years; P <.01) and had a lower prevalence of paroxysmal atrial fibrillation (PAF; 46% vs. 55%; P <.001). Females failed more antiarrhythmics (4 ± 1 vs. 2 ± 3; P = .04) and were referred later for catheter ablation (6.51 ± 7 vs. 4.85 ± 6.5 years; P = .02) than males. More females failed ablation (31.5% vs. 22.5%; P = .001) and had nonantral sites of firing than males (P <.001). Female patients had 11 (2.1%) hematomas versus 27 (0.9%) in males. Conclusions: Five times as many males underwent catheter ablation than females. Females failed more ablations possibly because of a higher prevalence of nonantral firing, non-PAF, and longer history of AF. Females had more bleeding complications than males.

KW - Atrial fibrillation

KW - Catheter ablation

KW - Female

KW - gender

KW - Hematoma

KW - Nonantral firing

KW - Pulmonary vein isolation

KW - Referral patterns

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