Outcomes and complications of catheter ablation for atrial fibrillation in females

Dimpi Patel; Prasant Mohanty; Luigi Di Biase; Javier E. Sanchez; Mazen H. Shaheen; J. David Burkhardt; Mohammed Bassouni; Jennifer Cummings; Yan Wang; William R. Lewis; Alberto Diaz; Rodney P. Horton; Salwa Beheiry; Richard Hongo; G. Joseph Gallinghouse; Jason D. Zagrodzky; Shane M. Bailey; Amin Al-Ahmad; Paul Wang; Robert A. Schweikert; Andrea Natale

doi:10.1016/j.hrthm.2009.10.025

Outcomes and complications of catheter ablation for atrial fibrillation in females

Dimpi Patel, Prasant Mohanty, Luigi Di Biase, Javier E. Sanchez, Mazen H. Shaheen, J. David Burkhardt, Mohammed Bassouni, Jennifer Cummings, Yan Wang, William R. Lewis, Alberto Diaz, Rodney P. Horton, Salwa Beheiry, Richard Hongo, G. Joseph Gallinghouse, Jason D. Zagrodzky, Shane M. Bailey, Amin Al-Ahmad, Paul Wang, Robert A. SchweikertAndrea Natale

Research output: Contribution to journal › Article › peer-review

193 Scopus citations

Abstract

Background: Most atrial fibrillation (AF) ablation studies have consisted predominantly of males; accordingly, there is a paucity of information on the safety and efficacy of catheter ablation in a large cohort of female AF patients. Objective: The purpose of this study was to evaluate catheter ablation for AF in female patients. Methods: From January 2005 to May 2008, 3265 females underwent pulmonary vein antrum isolation. Success rates, patient profiles, and complications were collected. Results: Approximately 16% of our population was female (P <.001). Females were older (59 ± 13 vs. 56 ± 19 years; P <.01) and had a lower prevalence of paroxysmal atrial fibrillation (PAF; 46% vs. 55%; P <.001). Females failed more antiarrhythmics (4 ± 1 vs. 2 ± 3; P = .04) and were referred later for catheter ablation (6.51 ± 7 vs. 4.85 ± 6.5 years; P = .02) than males. More females failed ablation (31.5% vs. 22.5%; P = .001) and had nonantral sites of firing than males (P <.001). Female patients had 11 (2.1%) hematomas versus 27 (0.9%) in males. Conclusions: Five times as many males underwent catheter ablation than females. Females failed more ablations possibly because of a higher prevalence of nonantral firing, non-PAF, and longer history of AF. Females had more bleeding complications than males.

Original language	English (US)
Pages (from-to)	167-172
Number of pages	6
Journal	Heart Rhythm
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/j.hrthm.2009.10.025
State	Published - 2010
Externally published	Yes

Keywords

Atrial fibrillation
Catheter ablation
Female
Hematoma
Nonantral firing
Pulmonary vein isolation
Referral patterns
gender

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1016/j.hrthm.2009.10.025

Cite this

Patel, D., Mohanty, P., Di Biase, L., Sanchez, J. E., Shaheen, M. H., Burkhardt, J. D., Bassouni, M., Cummings, J., Wang, Y., Lewis, W. R., Diaz, A., Horton, R. P., Beheiry, S., Hongo, R., Gallinghouse, G. J., Zagrodzky, J. D., Bailey, S. M., Al-Ahmad, A., Wang, P., ... Natale, A. (2010). Outcomes and complications of catheter ablation for atrial fibrillation in females. Heart Rhythm, 7(2), 167-172. https://doi.org/10.1016/j.hrthm.2009.10.025

Patel, D, Mohanty, P, Di Biase, L, Sanchez, JE, Shaheen, MH, Burkhardt, JD, Bassouni, M, Cummings, J, Wang, Y, Lewis, WR, Diaz, A, Horton, RP, Beheiry, S, Hongo, R, Gallinghouse, GJ, Zagrodzky, JD, Bailey, SM, Al-Ahmad, A, Wang, P, Schweikert, RA & Natale, A 2010, 'Outcomes and complications of catheter ablation for atrial fibrillation in females', Heart Rhythm, vol. 7, no. 2, pp. 167-172. https://doi.org/10.1016/j.hrthm.2009.10.025

@article{8c7977e667df428d9356d31031cb6a7b,

title = "Outcomes and complications of catheter ablation for atrial fibrillation in females",

abstract = "Background: Most atrial fibrillation (AF) ablation studies have consisted predominantly of males; accordingly, there is a paucity of information on the safety and efficacy of catheter ablation in a large cohort of female AF patients. Objective: The purpose of this study was to evaluate catheter ablation for AF in female patients. Methods: From January 2005 to May 2008, 3265 females underwent pulmonary vein antrum isolation. Success rates, patient profiles, and complications were collected. Results: Approximately 16% of our population was female (P <.001). Females were older (59 ± 13 vs. 56 ± 19 years; P <.01) and had a lower prevalence of paroxysmal atrial fibrillation (PAF; 46% vs. 55%; P <.001). Females failed more antiarrhythmics (4 ± 1 vs. 2 ± 3; P = .04) and were referred later for catheter ablation (6.51 ± 7 vs. 4.85 ± 6.5 years; P = .02) than males. More females failed ablation (31.5% vs. 22.5%; P = .001) and had nonantral sites of firing than males (P <.001). Female patients had 11 (2.1%) hematomas versus 27 (0.9%) in males. Conclusions: Five times as many males underwent catheter ablation than females. Females failed more ablations possibly because of a higher prevalence of nonantral firing, non-PAF, and longer history of AF. Females had more bleeding complications than males.",

keywords = "Atrial fibrillation, Catheter ablation, Female, Hematoma, Nonantral firing, Pulmonary vein isolation, Referral patterns, gender",

author = "Dimpi Patel and Prasant Mohanty and {Di Biase}, Luigi and Sanchez, {Javier E.} and Shaheen, {Mazen H.} and Burkhardt, {J. David} and Mohammed Bassouni and Jennifer Cummings and Yan Wang and Lewis, {William R.} and Alberto Diaz and Horton, {Rodney P.} and Salwa Beheiry and Richard Hongo and Gallinghouse, {G. Joseph} and Zagrodzky, {Jason D.} and Bailey, {Shane M.} and Amin Al-Ahmad and Paul Wang and Schweikert, {Robert A.} and Andrea Natale",

note = "Funding Information: J. David Burkhardt is a speaker for St. Jude Medical and Biosense Webster and Chief Medical Officer for Stereotaxis. Robert A. Schweikert is a consultant for Biosense Webster and a speaker for Medtronic, St. Jude Medical, Boston Scientific, Biosense Webster, and Reliant Pharmaceuticals. Andrea Natale is a speaker for St. Jude Medical, Boston Scientific, Medtronic, and Biosense Webster and a member of the Advisory Board for Stereotaxis and Biosense Webster. She also received a research grant from St. Jude Medical . Rodney Horton is on the Speakers' Bureau for Hansen Medical, St. Jude Medical, Medtronic, Boston Scientific, and Biosense Webster. Javier E. Sanchez receives speaker fees from Boston Scientific, St. Jude Medical, and Biosense Webster. G. Joseph Gallinghouse is a consultant for St. Jude Medical and Hansen Medical. All other authors have no conflicts of interest. ",

year = "2010",

doi = "10.1016/j.hrthm.2009.10.025",

language = "English (US)",

volume = "7",

pages = "167--172",

journal = "Heart Rhythm",

issn = "1547-5271",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Outcomes and complications of catheter ablation for atrial fibrillation in females

AU - Patel, Dimpi

AU - Mohanty, Prasant

AU - Di Biase, Luigi

AU - Sanchez, Javier E.

AU - Shaheen, Mazen H.

AU - Burkhardt, J. David

AU - Bassouni, Mohammed

AU - Cummings, Jennifer

AU - Wang, Yan

AU - Lewis, William R.

AU - Diaz, Alberto

AU - Horton, Rodney P.

AU - Beheiry, Salwa

AU - Hongo, Richard

AU - Gallinghouse, G. Joseph

AU - Zagrodzky, Jason D.

AU - Bailey, Shane M.

AU - Al-Ahmad, Amin

AU - Wang, Paul

AU - Schweikert, Robert A.

AU - Natale, Andrea

N1 - Funding Information: J. David Burkhardt is a speaker for St. Jude Medical and Biosense Webster and Chief Medical Officer for Stereotaxis. Robert A. Schweikert is a consultant for Biosense Webster and a speaker for Medtronic, St. Jude Medical, Boston Scientific, Biosense Webster, and Reliant Pharmaceuticals. Andrea Natale is a speaker for St. Jude Medical, Boston Scientific, Medtronic, and Biosense Webster and a member of the Advisory Board for Stereotaxis and Biosense Webster. She also received a research grant from St. Jude Medical . Rodney Horton is on the Speakers' Bureau for Hansen Medical, St. Jude Medical, Medtronic, Boston Scientific, and Biosense Webster. Javier E. Sanchez receives speaker fees from Boston Scientific, St. Jude Medical, and Biosense Webster. G. Joseph Gallinghouse is a consultant for St. Jude Medical and Hansen Medical. All other authors have no conflicts of interest.

PY - 2010

Y1 - 2010

N2 - Background: Most atrial fibrillation (AF) ablation studies have consisted predominantly of males; accordingly, there is a paucity of information on the safety and efficacy of catheter ablation in a large cohort of female AF patients. Objective: The purpose of this study was to evaluate catheter ablation for AF in female patients. Methods: From January 2005 to May 2008, 3265 females underwent pulmonary vein antrum isolation. Success rates, patient profiles, and complications were collected. Results: Approximately 16% of our population was female (P <.001). Females were older (59 ± 13 vs. 56 ± 19 years; P <.01) and had a lower prevalence of paroxysmal atrial fibrillation (PAF; 46% vs. 55%; P <.001). Females failed more antiarrhythmics (4 ± 1 vs. 2 ± 3; P = .04) and were referred later for catheter ablation (6.51 ± 7 vs. 4.85 ± 6.5 years; P = .02) than males. More females failed ablation (31.5% vs. 22.5%; P = .001) and had nonantral sites of firing than males (P <.001). Female patients had 11 (2.1%) hematomas versus 27 (0.9%) in males. Conclusions: Five times as many males underwent catheter ablation than females. Females failed more ablations possibly because of a higher prevalence of nonantral firing, non-PAF, and longer history of AF. Females had more bleeding complications than males.

AB - Background: Most atrial fibrillation (AF) ablation studies have consisted predominantly of males; accordingly, there is a paucity of information on the safety and efficacy of catheter ablation in a large cohort of female AF patients. Objective: The purpose of this study was to evaluate catheter ablation for AF in female patients. Methods: From January 2005 to May 2008, 3265 females underwent pulmonary vein antrum isolation. Success rates, patient profiles, and complications were collected. Results: Approximately 16% of our population was female (P <.001). Females were older (59 ± 13 vs. 56 ± 19 years; P <.01) and had a lower prevalence of paroxysmal atrial fibrillation (PAF; 46% vs. 55%; P <.001). Females failed more antiarrhythmics (4 ± 1 vs. 2 ± 3; P = .04) and were referred later for catheter ablation (6.51 ± 7 vs. 4.85 ± 6.5 years; P = .02) than males. More females failed ablation (31.5% vs. 22.5%; P = .001) and had nonantral sites of firing than males (P <.001). Female patients had 11 (2.1%) hematomas versus 27 (0.9%) in males. Conclusions: Five times as many males underwent catheter ablation than females. Females failed more ablations possibly because of a higher prevalence of nonantral firing, non-PAF, and longer history of AF. Females had more bleeding complications than males.

KW - Atrial fibrillation

KW - Catheter ablation

KW - Female

KW - Hematoma

KW - Nonantral firing

KW - Pulmonary vein isolation

KW - Referral patterns

KW - gender

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U2 - 10.1016/j.hrthm.2009.10.025

DO - 10.1016/j.hrthm.2009.10.025

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SN - 1547-5271

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JO - Heart Rhythm

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IS - 2

ER -

Outcomes and complications of catheter ablation for atrial fibrillation in females

Abstract

Keywords

ASJC Scopus subject areas

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