Outcome of pediatric live-donor liver transplantation - The Toronto experience

Steven Borenstein, Ivan R. Diamond, David R. Grant, Paul D. Greig, Nicola Jones, Vicky Ng, Eve Roberts, Annie Fecteau

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background/Purpose: Live-donor liver transplantation (LDLT) has developed to address the critical shortage of cadaveric organs that accounts for 20% of children who die while awaiting for a liver transplant in Ontario each year. This report reviews the outcome of the pediatric recipients of LDLT at the authors' center. Methods: The charts of all children who received a LDLT between June 1996 and March 2002 were reviewed retrospectively. Results: Thirteen children (mean age, 3.6 years) underwent LDLT. All donors were parents except for one cousin. Ten grafts were left-lateral segments, 2 were right lobes, and 1 was a left lobe. Three patients required a SILASTIC® (Dow Corning, Midland, MI) patch for delayed abdominal wall closure. Patient and graft survival rate was 100% with a median follow-up of 376 days. Major postoperative complications included biliary leaks (n = 2), biliary strictures (n = 1), portal vein thrombosis (n = 1), and hepatic venous complications (n = 1). There were no cases of hepatic artery thrombosis. Ten of 12 children became Positive for Epstein-Barr virus (EBV), and 3 of these patients had readily treatable post-transplant lymphoproliferative disorder. Conclusions: LDLT is an acceptable alternative to cadaveric transplantation for children with end-stage liver disease.

Original languageEnglish (US)
Pages (from-to)668-671
Number of pages4
JournalJournal of Pediatric Surgery
Volume38
Issue number5
DOIs
Publication statusPublished - May 1 2003
Externally publishedYes

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Keywords

  • Live donors
  • Liver transplantation
  • Outcome

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Borenstein, S., Diamond, I. R., Grant, D. R., Greig, P. D., Jones, N., Ng, V., ... Fecteau, A. (2003). Outcome of pediatric live-donor liver transplantation - The Toronto experience. Journal of Pediatric Surgery, 38(5), 668-671. https://doi.org/10.1016/jpsu.2003.50179