Outcome of Combined Liver and Kidney Transplantation in Hepatitis C: A Single-Center Long-Term Follow-up Experience

A. C. del Pozo, J. d R Martín, G. Rodriguez-Laiz, M. Sturdevant, K. Iyer, M. Schwartz, T. Schiano, S. Lerner, S. Ames, J. Bromberg, S. Thung, G. de Boccardo

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Introduction: Hepatitis C (HCV) cirrhosis is the prevalent liver disease requiring liver transplantation in the United States. Candidates who also have end-stage renal disease, chronic renal disease stage 4, or prolonged hepatorenal syndrome are considered for combined liver and kidney transplantation (CLKT). Materials and methods: We performed a retrospective study of HCV(+) and HCV(-) CLKT patients with more than 12 months of follow-up and HCV(+) patients with isolated liver transplant (OLT) to compare the outcomes of various groups. Results: Since 1988, 2983 OLTs were performed at our institution including 58 CLKTs. Of these, 23 were HCV(+) subjects who were significantly older than HCV(-) CLKT patients. Race, pretransplant dialysis time, renal indication for CLKT, Model for End-stage Liver Disease score, donor age, liver and kidney rejection as well as occurrence of posttransplant hypertension were similar among HCV(+) and HCV(-) CLKT patients. Posttransplant diabetes was observed in 80% of the HCV(+) group and 30% of the HCV(-) group (P = .01). Renal function seemed to be better in HCV(-) when compared with HCV(+) subjects at 5 years (P = .09). Overall patient survival for HCV(+) CLKT, HCV(-) CLKT, and HCV(+) OLT groups at 1, 2, and 5 years were not significantly different (P = .6). Conclusion: HCV positivity should not exclude appropriate candidates for CLKT.

Original languageEnglish (US)
Pages (from-to)1713-1716
Number of pages4
JournalTransplantation Proceedings
Volume41
Issue number5
DOIs
StatePublished - Jun 2009
Externally publishedYes

Fingerprint

Hepatitis C
Liver Transplantation
Kidney Transplantation
Hepatorenal Syndrome
Kidney
End Stage Liver Disease
Liver
Chronic Renal Insufficiency
Chronic Kidney Failure
Renal Dialysis
Liver Diseases
Fibrosis
Retrospective Studies
Tissue Donors
Hypertension
Transplants
Survival

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

del Pozo, A. C., Martín, J. D. R., Rodriguez-Laiz, G., Sturdevant, M., Iyer, K., Schwartz, M., ... de Boccardo, G. (2009). Outcome of Combined Liver and Kidney Transplantation in Hepatitis C: A Single-Center Long-Term Follow-up Experience. Transplantation Proceedings, 41(5), 1713-1716. https://doi.org/10.1016/j.transproceed.2009.02.103

Outcome of Combined Liver and Kidney Transplantation in Hepatitis C : A Single-Center Long-Term Follow-up Experience. / del Pozo, A. C.; Martín, J. d R; Rodriguez-Laiz, G.; Sturdevant, M.; Iyer, K.; Schwartz, M.; Schiano, T.; Lerner, S.; Ames, S.; Bromberg, J.; Thung, S.; de Boccardo, G.

In: Transplantation Proceedings, Vol. 41, No. 5, 06.2009, p. 1713-1716.

Research output: Contribution to journalArticle

del Pozo, AC, Martín, JDR, Rodriguez-Laiz, G, Sturdevant, M, Iyer, K, Schwartz, M, Schiano, T, Lerner, S, Ames, S, Bromberg, J, Thung, S & de Boccardo, G 2009, 'Outcome of Combined Liver and Kidney Transplantation in Hepatitis C: A Single-Center Long-Term Follow-up Experience', Transplantation Proceedings, vol. 41, no. 5, pp. 1713-1716. https://doi.org/10.1016/j.transproceed.2009.02.103
del Pozo, A. C. ; Martín, J. d R ; Rodriguez-Laiz, G. ; Sturdevant, M. ; Iyer, K. ; Schwartz, M. ; Schiano, T. ; Lerner, S. ; Ames, S. ; Bromberg, J. ; Thung, S. ; de Boccardo, G. / Outcome of Combined Liver and Kidney Transplantation in Hepatitis C : A Single-Center Long-Term Follow-up Experience. In: Transplantation Proceedings. 2009 ; Vol. 41, No. 5. pp. 1713-1716.
@article{8e1ed6c257854ae786a93baff01b8bd6,
title = "Outcome of Combined Liver and Kidney Transplantation in Hepatitis C: A Single-Center Long-Term Follow-up Experience",
abstract = "Introduction: Hepatitis C (HCV) cirrhosis is the prevalent liver disease requiring liver transplantation in the United States. Candidates who also have end-stage renal disease, chronic renal disease stage 4, or prolonged hepatorenal syndrome are considered for combined liver and kidney transplantation (CLKT). Materials and methods: We performed a retrospective study of HCV(+) and HCV(-) CLKT patients with more than 12 months of follow-up and HCV(+) patients with isolated liver transplant (OLT) to compare the outcomes of various groups. Results: Since 1988, 2983 OLTs were performed at our institution including 58 CLKTs. Of these, 23 were HCV(+) subjects who were significantly older than HCV(-) CLKT patients. Race, pretransplant dialysis time, renal indication for CLKT, Model for End-stage Liver Disease score, donor age, liver and kidney rejection as well as occurrence of posttransplant hypertension were similar among HCV(+) and HCV(-) CLKT patients. Posttransplant diabetes was observed in 80{\%} of the HCV(+) group and 30{\%} of the HCV(-) group (P = .01). Renal function seemed to be better in HCV(-) when compared with HCV(+) subjects at 5 years (P = .09). Overall patient survival for HCV(+) CLKT, HCV(-) CLKT, and HCV(+) OLT groups at 1, 2, and 5 years were not significantly different (P = .6). Conclusion: HCV positivity should not exclude appropriate candidates for CLKT.",
author = "{del Pozo}, {A. C.} and Mart{\'i}n, {J. d R} and G. Rodriguez-Laiz and M. Sturdevant and K. Iyer and M. Schwartz and T. Schiano and S. Lerner and S. Ames and J. Bromberg and S. Thung and {de Boccardo}, G.",
year = "2009",
month = "6",
doi = "10.1016/j.transproceed.2009.02.103",
language = "English (US)",
volume = "41",
pages = "1713--1716",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - Outcome of Combined Liver and Kidney Transplantation in Hepatitis C

T2 - A Single-Center Long-Term Follow-up Experience

AU - del Pozo, A. C.

AU - Martín, J. d R

AU - Rodriguez-Laiz, G.

AU - Sturdevant, M.

AU - Iyer, K.

AU - Schwartz, M.

AU - Schiano, T.

AU - Lerner, S.

AU - Ames, S.

AU - Bromberg, J.

AU - Thung, S.

AU - de Boccardo, G.

PY - 2009/6

Y1 - 2009/6

N2 - Introduction: Hepatitis C (HCV) cirrhosis is the prevalent liver disease requiring liver transplantation in the United States. Candidates who also have end-stage renal disease, chronic renal disease stage 4, or prolonged hepatorenal syndrome are considered for combined liver and kidney transplantation (CLKT). Materials and methods: We performed a retrospective study of HCV(+) and HCV(-) CLKT patients with more than 12 months of follow-up and HCV(+) patients with isolated liver transplant (OLT) to compare the outcomes of various groups. Results: Since 1988, 2983 OLTs were performed at our institution including 58 CLKTs. Of these, 23 were HCV(+) subjects who were significantly older than HCV(-) CLKT patients. Race, pretransplant dialysis time, renal indication for CLKT, Model for End-stage Liver Disease score, donor age, liver and kidney rejection as well as occurrence of posttransplant hypertension were similar among HCV(+) and HCV(-) CLKT patients. Posttransplant diabetes was observed in 80% of the HCV(+) group and 30% of the HCV(-) group (P = .01). Renal function seemed to be better in HCV(-) when compared with HCV(+) subjects at 5 years (P = .09). Overall patient survival for HCV(+) CLKT, HCV(-) CLKT, and HCV(+) OLT groups at 1, 2, and 5 years were not significantly different (P = .6). Conclusion: HCV positivity should not exclude appropriate candidates for CLKT.

AB - Introduction: Hepatitis C (HCV) cirrhosis is the prevalent liver disease requiring liver transplantation in the United States. Candidates who also have end-stage renal disease, chronic renal disease stage 4, or prolonged hepatorenal syndrome are considered for combined liver and kidney transplantation (CLKT). Materials and methods: We performed a retrospective study of HCV(+) and HCV(-) CLKT patients with more than 12 months of follow-up and HCV(+) patients with isolated liver transplant (OLT) to compare the outcomes of various groups. Results: Since 1988, 2983 OLTs were performed at our institution including 58 CLKTs. Of these, 23 were HCV(+) subjects who were significantly older than HCV(-) CLKT patients. Race, pretransplant dialysis time, renal indication for CLKT, Model for End-stage Liver Disease score, donor age, liver and kidney rejection as well as occurrence of posttransplant hypertension were similar among HCV(+) and HCV(-) CLKT patients. Posttransplant diabetes was observed in 80% of the HCV(+) group and 30% of the HCV(-) group (P = .01). Renal function seemed to be better in HCV(-) when compared with HCV(+) subjects at 5 years (P = .09). Overall patient survival for HCV(+) CLKT, HCV(-) CLKT, and HCV(+) OLT groups at 1, 2, and 5 years were not significantly different (P = .6). Conclusion: HCV positivity should not exclude appropriate candidates for CLKT.

UR - http://www.scopus.com/inward/record.url?scp=67249153575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67249153575&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2009.02.103

DO - 10.1016/j.transproceed.2009.02.103

M3 - Article

C2 - 19545713

AN - SCOPUS:67249153575

VL - 41

SP - 1713

EP - 1716

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 5

ER -