Outcome of Combined Liver and Kidney Transplantation in Hepatitis C: A Single-Center Long-Term Follow-up Experience

A. C. del Pozo, J. d.R. Martín, G. Rodriguez-Laiz, M. Sturdevant, K. Iyer, M. Schwartz, T. Schiano, S. Lerner, S. Ames, J. Bromberg, S. Thung, G. de Boccardo

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Introduction: Hepatitis C (HCV) cirrhosis is the prevalent liver disease requiring liver transplantation in the United States. Candidates who also have end-stage renal disease, chronic renal disease stage 4, or prolonged hepatorenal syndrome are considered for combined liver and kidney transplantation (CLKT). Materials and methods: We performed a retrospective study of HCV(+) and HCV(-) CLKT patients with more than 12 months of follow-up and HCV(+) patients with isolated liver transplant (OLT) to compare the outcomes of various groups. Results: Since 1988, 2983 OLTs were performed at our institution including 58 CLKTs. Of these, 23 were HCV(+) subjects who were significantly older than HCV(-) CLKT patients. Race, pretransplant dialysis time, renal indication for CLKT, Model for End-stage Liver Disease score, donor age, liver and kidney rejection as well as occurrence of posttransplant hypertension were similar among HCV(+) and HCV(-) CLKT patients. Posttransplant diabetes was observed in 80% of the HCV(+) group and 30% of the HCV(-) group (P = .01). Renal function seemed to be better in HCV(-) when compared with HCV(+) subjects at 5 years (P = .09). Overall patient survival for HCV(+) CLKT, HCV(-) CLKT, and HCV(+) OLT groups at 1, 2, and 5 years were not significantly different (P = .6). Conclusion: HCV positivity should not exclude appropriate candidates for CLKT.

Original languageEnglish (US)
Pages (from-to)1713-1716
Number of pages4
JournalTransplantation Proceedings
Volume41
Issue number5
DOIs
StatePublished - Jun 1 2009

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    del Pozo, A. C., Martín, J. D. R., Rodriguez-Laiz, G., Sturdevant, M., Iyer, K., Schwartz, M., Schiano, T., Lerner, S., Ames, S., Bromberg, J., Thung, S., & de Boccardo, G. (2009). Outcome of Combined Liver and Kidney Transplantation in Hepatitis C: A Single-Center Long-Term Follow-up Experience. Transplantation Proceedings, 41(5), 1713-1716. https://doi.org/10.1016/j.transproceed.2009.02.103