TY - JOUR
T1 - Outcome of Combined Liver and Kidney Transplantation in Hepatitis C
T2 - A Single-Center Long-Term Follow-up Experience
AU - del Pozo, A. C.
AU - Martín, J. d.R.
AU - Rodriguez-Laiz, G.
AU - Sturdevant, M.
AU - Iyer, K.
AU - Schwartz, M.
AU - Schiano, T.
AU - Lerner, S.
AU - Ames, S.
AU - Bromberg, J.
AU - Thung, S.
AU - de Boccardo, G.
PY - 2009/6
Y1 - 2009/6
N2 - Introduction: Hepatitis C (HCV) cirrhosis is the prevalent liver disease requiring liver transplantation in the United States. Candidates who also have end-stage renal disease, chronic renal disease stage 4, or prolonged hepatorenal syndrome are considered for combined liver and kidney transplantation (CLKT). Materials and methods: We performed a retrospective study of HCV(+) and HCV(-) CLKT patients with more than 12 months of follow-up and HCV(+) patients with isolated liver transplant (OLT) to compare the outcomes of various groups. Results: Since 1988, 2983 OLTs were performed at our institution including 58 CLKTs. Of these, 23 were HCV(+) subjects who were significantly older than HCV(-) CLKT patients. Race, pretransplant dialysis time, renal indication for CLKT, Model for End-stage Liver Disease score, donor age, liver and kidney rejection as well as occurrence of posttransplant hypertension were similar among HCV(+) and HCV(-) CLKT patients. Posttransplant diabetes was observed in 80% of the HCV(+) group and 30% of the HCV(-) group (P = .01). Renal function seemed to be better in HCV(-) when compared with HCV(+) subjects at 5 years (P = .09). Overall patient survival for HCV(+) CLKT, HCV(-) CLKT, and HCV(+) OLT groups at 1, 2, and 5 years were not significantly different (P = .6). Conclusion: HCV positivity should not exclude appropriate candidates for CLKT.
AB - Introduction: Hepatitis C (HCV) cirrhosis is the prevalent liver disease requiring liver transplantation in the United States. Candidates who also have end-stage renal disease, chronic renal disease stage 4, or prolonged hepatorenal syndrome are considered for combined liver and kidney transplantation (CLKT). Materials and methods: We performed a retrospective study of HCV(+) and HCV(-) CLKT patients with more than 12 months of follow-up and HCV(+) patients with isolated liver transplant (OLT) to compare the outcomes of various groups. Results: Since 1988, 2983 OLTs were performed at our institution including 58 CLKTs. Of these, 23 were HCV(+) subjects who were significantly older than HCV(-) CLKT patients. Race, pretransplant dialysis time, renal indication for CLKT, Model for End-stage Liver Disease score, donor age, liver and kidney rejection as well as occurrence of posttransplant hypertension were similar among HCV(+) and HCV(-) CLKT patients. Posttransplant diabetes was observed in 80% of the HCV(+) group and 30% of the HCV(-) group (P = .01). Renal function seemed to be better in HCV(-) when compared with HCV(+) subjects at 5 years (P = .09). Overall patient survival for HCV(+) CLKT, HCV(-) CLKT, and HCV(+) OLT groups at 1, 2, and 5 years were not significantly different (P = .6). Conclusion: HCV positivity should not exclude appropriate candidates for CLKT.
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U2 - 10.1016/j.transproceed.2009.02.103
DO - 10.1016/j.transproceed.2009.02.103
M3 - Article
C2 - 19545713
AN - SCOPUS:67249153575
SN - 0041-1345
VL - 41
SP - 1713
EP - 1716
JO - Transplantation proceedings
JF - Transplantation proceedings
IS - 5
ER -