Outcome and profile of ventricular septal rupture with cardiogenic shock after myocardial infarction

A report from the SHOCK Trial Registry

Venu Menon, John G. Webb, L. David Hillis, Lynn A. Sleeper, Rasha Abboud, Vladimir Dzavik, James N. Slater, Robert Forman, E. Scott Monrad, J. David Talley, Judith S. Hochman

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

OBJECTIVES: We wished to assess the profile and outcomes of patients with ventricular septal rupture (VSR) in the setting of cardiogenic shock (CS) complicating acute myocardial infarction (MI). BACKGROUND: Cardiogenic shock is often seen with VSR complicating acute MI. Despite surgical therapy, mortality in such patients is high. METHODS: We analyzed 939 patients enrolled in the SHOCK Trial Registry of CS in acute infarction, comparing 55 patients whose shock was associated with VSR with 884 patients who had predominant left ventricular failure. RESULTS: Rupture occurred a median 16 h after infarction. Patients with VSR tended to be older (p = 0.053), were more often female (p = 0.002) and less often had previous infarction (p < 0.001), diabetes mellitus (p = 0.015) or smoking history (p = 0.033). They also underwent right-heart catheterization, intra-aortic balloon pumping and bypass surgery significantly more often. Although patients with rupture had less severe coronary disease, their in-hospital mortality was higher (87% vs. 61%, p < 0.001). Surgical repair was performed in 31 patients with rupture (21 had concomitant bypass surgery); 6 (19%) survived. Of the 24 patients managed medically, only 1 survived. CONCLUSIONS: There is a high in-hospital mortality rate when CS develops as a result of VSR. Ventricular septal rupture may occur early after infarction, and women and the elderly may be more susceptible. Although the prognosis is poor, surgery remains the best therapeutic option in this setting. (C) 2000 by the American College of Cardiology.

Original languageEnglish (US)
Pages (from-to)1110-1116
Number of pages7
JournalJournal of the American College of Cardiology
Volume36
Issue number3 SUPPL. A
DOIs
StatePublished - 2000

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Ventricular Septal Rupture
Cardiogenic Shock
Registries
Myocardial Infarction
Infarction
Rupture
Hospital Mortality
Intra-Aortic Balloon Pumping
Mortality
Cardiac Catheterization
Coronary Disease
Shock
Diabetes Mellitus
Smoking
History

ASJC Scopus subject areas

  • Nursing(all)

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Outcome and profile of ventricular septal rupture with cardiogenic shock after myocardial infarction : A report from the SHOCK Trial Registry. / Menon, Venu; Webb, John G.; Hillis, L. David; Sleeper, Lynn A.; Abboud, Rasha; Dzavik, Vladimir; Slater, James N.; Forman, Robert; Monrad, E. Scott; Talley, J. David; Hochman, Judith S.

In: Journal of the American College of Cardiology, Vol. 36, No. 3 SUPPL. A, 2000, p. 1110-1116.

Research output: Contribution to journalArticle

Menon, Venu ; Webb, John G. ; Hillis, L. David ; Sleeper, Lynn A. ; Abboud, Rasha ; Dzavik, Vladimir ; Slater, James N. ; Forman, Robert ; Monrad, E. Scott ; Talley, J. David ; Hochman, Judith S. / Outcome and profile of ventricular septal rupture with cardiogenic shock after myocardial infarction : A report from the SHOCK Trial Registry. In: Journal of the American College of Cardiology. 2000 ; Vol. 36, No. 3 SUPPL. A. pp. 1110-1116.
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abstract = "OBJECTIVES: We wished to assess the profile and outcomes of patients with ventricular septal rupture (VSR) in the setting of cardiogenic shock (CS) complicating acute myocardial infarction (MI). BACKGROUND: Cardiogenic shock is often seen with VSR complicating acute MI. Despite surgical therapy, mortality in such patients is high. METHODS: We analyzed 939 patients enrolled in the SHOCK Trial Registry of CS in acute infarction, comparing 55 patients whose shock was associated with VSR with 884 patients who had predominant left ventricular failure. RESULTS: Rupture occurred a median 16 h after infarction. Patients with VSR tended to be older (p = 0.053), were more often female (p = 0.002) and less often had previous infarction (p < 0.001), diabetes mellitus (p = 0.015) or smoking history (p = 0.033). They also underwent right-heart catheterization, intra-aortic balloon pumping and bypass surgery significantly more often. Although patients with rupture had less severe coronary disease, their in-hospital mortality was higher (87{\%} vs. 61{\%}, p < 0.001). Surgical repair was performed in 31 patients with rupture (21 had concomitant bypass surgery); 6 (19{\%}) survived. Of the 24 patients managed medically, only 1 survived. CONCLUSIONS: There is a high in-hospital mortality rate when CS develops as a result of VSR. Ventricular septal rupture may occur early after infarction, and women and the elderly may be more susceptible. Although the prognosis is poor, surgery remains the best therapeutic option in this setting. (C) 2000 by the American College of Cardiology.",
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T1 - Outcome and profile of ventricular septal rupture with cardiogenic shock after myocardial infarction

T2 - A report from the SHOCK Trial Registry

AU - Menon, Venu

AU - Webb, John G.

AU - Hillis, L. David

AU - Sleeper, Lynn A.

AU - Abboud, Rasha

AU - Dzavik, Vladimir

AU - Slater, James N.

AU - Forman, Robert

AU - Monrad, E. Scott

AU - Talley, J. David

AU - Hochman, Judith S.

PY - 2000

Y1 - 2000

N2 - OBJECTIVES: We wished to assess the profile and outcomes of patients with ventricular septal rupture (VSR) in the setting of cardiogenic shock (CS) complicating acute myocardial infarction (MI). BACKGROUND: Cardiogenic shock is often seen with VSR complicating acute MI. Despite surgical therapy, mortality in such patients is high. METHODS: We analyzed 939 patients enrolled in the SHOCK Trial Registry of CS in acute infarction, comparing 55 patients whose shock was associated with VSR with 884 patients who had predominant left ventricular failure. RESULTS: Rupture occurred a median 16 h after infarction. Patients with VSR tended to be older (p = 0.053), were more often female (p = 0.002) and less often had previous infarction (p < 0.001), diabetes mellitus (p = 0.015) or smoking history (p = 0.033). They also underwent right-heart catheterization, intra-aortic balloon pumping and bypass surgery significantly more often. Although patients with rupture had less severe coronary disease, their in-hospital mortality was higher (87% vs. 61%, p < 0.001). Surgical repair was performed in 31 patients with rupture (21 had concomitant bypass surgery); 6 (19%) survived. Of the 24 patients managed medically, only 1 survived. CONCLUSIONS: There is a high in-hospital mortality rate when CS develops as a result of VSR. Ventricular septal rupture may occur early after infarction, and women and the elderly may be more susceptible. Although the prognosis is poor, surgery remains the best therapeutic option in this setting. (C) 2000 by the American College of Cardiology.

AB - OBJECTIVES: We wished to assess the profile and outcomes of patients with ventricular septal rupture (VSR) in the setting of cardiogenic shock (CS) complicating acute myocardial infarction (MI). BACKGROUND: Cardiogenic shock is often seen with VSR complicating acute MI. Despite surgical therapy, mortality in such patients is high. METHODS: We analyzed 939 patients enrolled in the SHOCK Trial Registry of CS in acute infarction, comparing 55 patients whose shock was associated with VSR with 884 patients who had predominant left ventricular failure. RESULTS: Rupture occurred a median 16 h after infarction. Patients with VSR tended to be older (p = 0.053), were more often female (p = 0.002) and less often had previous infarction (p < 0.001), diabetes mellitus (p = 0.015) or smoking history (p = 0.033). They also underwent right-heart catheterization, intra-aortic balloon pumping and bypass surgery significantly more often. Although patients with rupture had less severe coronary disease, their in-hospital mortality was higher (87% vs. 61%, p < 0.001). Surgical repair was performed in 31 patients with rupture (21 had concomitant bypass surgery); 6 (19%) survived. Of the 24 patients managed medically, only 1 survived. CONCLUSIONS: There is a high in-hospital mortality rate when CS develops as a result of VSR. Ventricular septal rupture may occur early after infarction, and women and the elderly may be more susceptible. Although the prognosis is poor, surgery remains the best therapeutic option in this setting. (C) 2000 by the American College of Cardiology.

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JO - Journal of the American College of Cardiology

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SN - 0735-1097

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