Outcome and long-term growth after extensive small bowel resection in the neonatal period

A survey of 87 children

Oliver Goulet, S. Baglin-Gobet, C. Talbotec, L. Fourcade, V. Colomb, F. Sauvat, J. P. Jais, J. L. Michel, Dominique M. Jan, C. Ricour

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

This retrospective study aims to analyze the outcome, the prognosis factors and the long-term growth of children after extensive small bowel (SB) resection in the neonatal period. Patients and Methods: 87 children, born between 1975 and 1991 who had undergone extensive neonatal small bowel resection, were followed up over a mean period of 15 years. Anatomical data influencing PN dependency and duration were analyzed. Data on height and weight were collected and compared using growth standards. Final heights were studied for patients who achieved their puberty and compared to predicted height based on Tanner's formula. Patients were analyzed according to PN weaning and growth: children still receiving PN (group A), patients weaned from initial PN but requiring PN once again or enteral feeding (group B), and children with permanent intestinal autonomy (group C). Results: The overall survival is 89.7%, depending on the date of birth. The duration of PN-dependency varies according to the intestinal length and the presence of the ileocaecal valve (ICV). All patients who remain PN dependent had less than 40 cm of small bowel and/or the absence of ICV. Patients in group B had a mean small bowel length of 35 ± 19 cm, resection of the ICV in 50% of cases, and a PN duration of 47.4 ± 23.8 months. There was a significant decrease in height and weight gain within the 4 years after cessation of PN, requiring enteral or parenteral feeding. Patients in group C had a mean small bowel length of 57 ± 19 cm, presence of ICV in 81% of cases and a PN duration of 16.1 ± 11.4 months. After PN weaning, they grow up normally with normal puberty and final height as predicted from genetic target height. Conclusion: PN duration is influenced by the length of residual SB and the absence of ICV. With good anatomic prognosis factors and short duration of initial PN, normal long-term growth may be predicted. Conversely, poor anatomical factors and protracted initial PN require careful monitoring of growth and may sometimes require nutritional support to be restarted. The last group, permanently dependent on PN, might be candidates for intestinal transplantation.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalEuropean Journal of Pediatric Surgery
Volume15
Issue number2
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Ileocecal Valve
Growth
Enteral Nutrition
Puberty
Weaning
Nutritional Support
Parenteral Nutrition
Surveys and Questionnaires
Weight Gain
Retrospective Studies
Transplantation
Parturition
Weights and Measures
Survival

Keywords

  • Growth
  • Infant
  • Intestinal adaptation
  • Neonate
  • Parenteral nutrition
  • Puberty
  • Short bowel syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Outcome and long-term growth after extensive small bowel resection in the neonatal period : A survey of 87 children. / Goulet, Oliver; Baglin-Gobet, S.; Talbotec, C.; Fourcade, L.; Colomb, V.; Sauvat, F.; Jais, J. P.; Michel, J. L.; Jan, Dominique M.; Ricour, C.

In: European Journal of Pediatric Surgery, Vol. 15, No. 2, 04.2005, p. 95-101.

Research output: Contribution to journalArticle

Goulet, O, Baglin-Gobet, S, Talbotec, C, Fourcade, L, Colomb, V, Sauvat, F, Jais, JP, Michel, JL, Jan, DM & Ricour, C 2005, 'Outcome and long-term growth after extensive small bowel resection in the neonatal period: A survey of 87 children', European Journal of Pediatric Surgery, vol. 15, no. 2, pp. 95-101. https://doi.org/10.1055/s-2004-821214
Goulet, Oliver ; Baglin-Gobet, S. ; Talbotec, C. ; Fourcade, L. ; Colomb, V. ; Sauvat, F. ; Jais, J. P. ; Michel, J. L. ; Jan, Dominique M. ; Ricour, C. / Outcome and long-term growth after extensive small bowel resection in the neonatal period : A survey of 87 children. In: European Journal of Pediatric Surgery. 2005 ; Vol. 15, No. 2. pp. 95-101.
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abstract = "This retrospective study aims to analyze the outcome, the prognosis factors and the long-term growth of children after extensive small bowel (SB) resection in the neonatal period. Patients and Methods: 87 children, born between 1975 and 1991 who had undergone extensive neonatal small bowel resection, were followed up over a mean period of 15 years. Anatomical data influencing PN dependency and duration were analyzed. Data on height and weight were collected and compared using growth standards. Final heights were studied for patients who achieved their puberty and compared to predicted height based on Tanner's formula. Patients were analyzed according to PN weaning and growth: children still receiving PN (group A), patients weaned from initial PN but requiring PN once again or enteral feeding (group B), and children with permanent intestinal autonomy (group C). Results: The overall survival is 89.7{\%}, depending on the date of birth. The duration of PN-dependency varies according to the intestinal length and the presence of the ileocaecal valve (ICV). All patients who remain PN dependent had less than 40 cm of small bowel and/or the absence of ICV. Patients in group B had a mean small bowel length of 35 ± 19 cm, resection of the ICV in 50{\%} of cases, and a PN duration of 47.4 ± 23.8 months. There was a significant decrease in height and weight gain within the 4 years after cessation of PN, requiring enteral or parenteral feeding. Patients in group C had a mean small bowel length of 57 ± 19 cm, presence of ICV in 81{\%} of cases and a PN duration of 16.1 ± 11.4 months. After PN weaning, they grow up normally with normal puberty and final height as predicted from genetic target height. Conclusion: PN duration is influenced by the length of residual SB and the absence of ICV. With good anatomic prognosis factors and short duration of initial PN, normal long-term growth may be predicted. Conversely, poor anatomical factors and protracted initial PN require careful monitoring of growth and may sometimes require nutritional support to be restarted. The last group, permanently dependent on PN, might be candidates for intestinal transplantation.",
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AU - Fourcade, L.

AU - Colomb, V.

AU - Sauvat, F.

AU - Jais, J. P.

AU - Michel, J. L.

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N2 - This retrospective study aims to analyze the outcome, the prognosis factors and the long-term growth of children after extensive small bowel (SB) resection in the neonatal period. Patients and Methods: 87 children, born between 1975 and 1991 who had undergone extensive neonatal small bowel resection, were followed up over a mean period of 15 years. Anatomical data influencing PN dependency and duration were analyzed. Data on height and weight were collected and compared using growth standards. Final heights were studied for patients who achieved their puberty and compared to predicted height based on Tanner's formula. Patients were analyzed according to PN weaning and growth: children still receiving PN (group A), patients weaned from initial PN but requiring PN once again or enteral feeding (group B), and children with permanent intestinal autonomy (group C). Results: The overall survival is 89.7%, depending on the date of birth. The duration of PN-dependency varies according to the intestinal length and the presence of the ileocaecal valve (ICV). All patients who remain PN dependent had less than 40 cm of small bowel and/or the absence of ICV. Patients in group B had a mean small bowel length of 35 ± 19 cm, resection of the ICV in 50% of cases, and a PN duration of 47.4 ± 23.8 months. There was a significant decrease in height and weight gain within the 4 years after cessation of PN, requiring enteral or parenteral feeding. Patients in group C had a mean small bowel length of 57 ± 19 cm, presence of ICV in 81% of cases and a PN duration of 16.1 ± 11.4 months. After PN weaning, they grow up normally with normal puberty and final height as predicted from genetic target height. Conclusion: PN duration is influenced by the length of residual SB and the absence of ICV. With good anatomic prognosis factors and short duration of initial PN, normal long-term growth may be predicted. Conversely, poor anatomical factors and protracted initial PN require careful monitoring of growth and may sometimes require nutritional support to be restarted. The last group, permanently dependent on PN, might be candidates for intestinal transplantation.

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