Out of the frying pan: Dietary saturated fat influences nonalcoholic fatty liver disease

Elizabeth Parks, Hannele Yki-Järvinen, Meredith A. Hawkins

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Nonalcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of fat in the liver. In some cases, NAFLD is also accompanied by insulin resistance, resulting in metabolic dysfunction. Dietary fat content probably influences both NAFLD and insulin resistance; however, the immediate effects of fat consumption have not been fully explored. In this issue of the JCI, Hernández et al. evaluated hepatic glucose and lipid metabolism in humans and mice following a single oral dose of saturated fat. This one bolus of fat resulted in a measurable increase in insulin resistance, hepatic triglycerides, and gluconeogenesis. In mice, the saturated fat bolus resulted in the induction of several NAFLD-associated genes. Together, the results of this study indicate that saturated fat intake has immediate effects on metabolic function.

Original languageEnglish (US)
Pages (from-to)454-456
Number of pages3
JournalJournal of Clinical Investigation
Volume127
Issue number2
DOIs
StatePublished - Feb 1 2017

ASJC Scopus subject areas

  • Medicine(all)

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