Osteosarcoma associated with absent thumbs: A report of two cases

L. Orme, R. Gorlick, P. A. Meyers, E. Athanasian, A. G. Huvos

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An 8-year-old Hispanic boy with a hypoplastic left thumb, absent right thumb, and short stature experienced right leg pain and limp. A right tibial lesion was imaged and found to be osteosarcoma on biopsy. A 6-year-old Hispanic girl with congenitally absent thumbs experienced a pathologic fracture of her left femur after a minor sports injury. The radiologic abnormality seen was diagnosed as osteosarcoma on biopsy. Both patients continue to do well after intensive preoperative and postoperative high-dose chemotherapy and definitive reconstructive limb surgery. Osteosarcoma has been linked to several congenital syndromes in which absent thumbs are a feature. These two patients with absent thumbs and no definable syndrome experiencing osteosarcoma suggest that congenitally absent thumbs might be a risk factor for osteosarcoma in the absence of a syndrome.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Volume22
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Thumb
Osteosarcoma
Hispanic Americans
Reconstructive Surgical Procedures
Biopsy
Athletic Injuries
Spontaneous Fractures
Femur
Leg
Extremities
Drug Therapy
Pain

Keywords

  • Baller-Gerold syndrome
  • Fanconi anemia
  • Hypoplastic-aplastic thumb
  • Osteosarcoma
  • Rothmund-Thomson syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Osteosarcoma associated with absent thumbs : A report of two cases. / Orme, L.; Gorlick, R.; Meyers, P. A.; Athanasian, E.; Huvos, A. G.

In: Journal of Pediatric Hematology/Oncology, Vol. 22, No. 1, 2000, p. 73-77.

Research output: Contribution to journalArticle

Orme, L. ; Gorlick, R. ; Meyers, P. A. ; Athanasian, E. ; Huvos, A. G. / Osteosarcoma associated with absent thumbs : A report of two cases. In: Journal of Pediatric Hematology/Oncology. 2000 ; Vol. 22, No. 1. pp. 73-77.
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