Osteopetrotic (op/op) Mice Deficient in Macrophages Have the Ability to Mount a Normal T-Cell-Dependent Immune Response

Ming Der Y Chang, E. Richard Stanley, Houman Khalili, Orin Chisholm, Jeffrey W. Pollard

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The osteopetrotic (op/op) mouse possesses an inactivating mutation in the CSF-1 gene that is associated with a lack of certain mononuclear phagocyte populations. To examine the effects of these deficiencies on T-cell-dependent immune functions, the responses of op/ op and normal mice to a T-cell-dependent antigen, ovalbumin, and to a foreign histocompatibility antigen were compared. The ability of op/op mice (1) to induce antigen-specific proliferation of naive T-cells, (2) to generate cytotoxic T-lymphocytes, (3) to supply spleen cells to serve as stimulators in a mixed lymphocyte reaction, and (4) to produce IgM and IgG antibodies was indistinguishable from normal mice. These data are consistent with the involvement of specific macrophages, or other cells whose development is independent of CSF-1, in these immune responses.

Original languageEnglish (US)
Pages (from-to)146-152
Number of pages7
JournalCellular Immunology
Volume162
Issue number1
DOIs
StatePublished - Apr 15 1995

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Macrophages
T-Lymphocytes
Macrophage Colony-Stimulating Factor
Antigens
Mixed Lymphocyte Culture Test
Histocompatibility Antigens
Ovalbumin
Cytotoxic T-Lymphocytes
Phagocytes
Immunoglobulin M
Spleen
Immunoglobulin G
Mutation
Antibodies
Population
Genes

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Osteopetrotic (op/op) Mice Deficient in Macrophages Have the Ability to Mount a Normal T-Cell-Dependent Immune Response. / Chang, Ming Der Y; Stanley, E. Richard; Khalili, Houman; Chisholm, Orin; Pollard, Jeffrey W.

In: Cellular Immunology, Vol. 162, No. 1, 15.04.1995, p. 146-152.

Research output: Contribution to journalArticle

Chang, Ming Der Y ; Stanley, E. Richard ; Khalili, Houman ; Chisholm, Orin ; Pollard, Jeffrey W. / Osteopetrotic (op/op) Mice Deficient in Macrophages Have the Ability to Mount a Normal T-Cell-Dependent Immune Response. In: Cellular Immunology. 1995 ; Vol. 162, No. 1. pp. 146-152.
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