Osteogenic and ewing sarcomas: Estimation of necrotic fraction during induction chemotherapy with dynamic contrastenhanced MR imaging

Jonathan P. Dyke, David M. Panicek, John H. Healey, Paul A. Meyers, Andrew G. Huvos, Lawrence H. Schwartz, Howard T. Thaler, Paul S. Tofts, Richard Gorlick, Jason A. Koutcher, Douglas Ballon

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Dynamic contrast material - enhanced magnetic resonance (MR) images of primary osteogenic sarcoma (n = 19) and Ewing sarcoma (n = 10) were reviewed in 29 patients under-going induction chemotherapy before surgery. Histogram distributions containing the initial slope and pharmacokinetic model parameters from individual voxels within each tumor were fitted for each patient. The histogram analysis of initial slope from the tumor correlated well with percentage necrosis as determined at pathologic examination (r = 0.60, P < .001), as did a two-compartment pharmacokinetic model (r = 0.64, P < .001). Both methods predicted tumors with clinically important degrees of necrosis (ie, ≥90%) in a large majority of cases. The ability to determine response to induction chemotherapy by means of noninvasive monitoring of necrotic fraction with perfusion MR imaging methods may provide useful prognostic information and help surgical planning.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalRadiology
Volume228
Issue number1
DOIs
StatePublished - Jul 1 2003
Externally publishedYes

Fingerprint

Induction Chemotherapy
Ewing's Sarcoma
Osteosarcoma
Magnetic Resonance Imaging
Necrosis
Pharmacokinetics
Neoplasms
Magnetic Resonance Angiography
Contrast Media
Magnetic Resonance Spectroscopy

Keywords

  • Bone neoplasms, MR
  • Chemotherapy
  • Ewing sarcoma
  • Osteosarcoma

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Dyke, J. P., Panicek, D. M., Healey, J. H., Meyers, P. A., Huvos, A. G., Schwartz, L. H., ... Ballon, D. (2003). Osteogenic and ewing sarcomas: Estimation of necrotic fraction during induction chemotherapy with dynamic contrastenhanced MR imaging. Radiology, 228(1), 271-278. https://doi.org/10.1148/radiol.2281011651

Osteogenic and ewing sarcomas : Estimation of necrotic fraction during induction chemotherapy with dynamic contrastenhanced MR imaging. / Dyke, Jonathan P.; Panicek, David M.; Healey, John H.; Meyers, Paul A.; Huvos, Andrew G.; Schwartz, Lawrence H.; Thaler, Howard T.; Tofts, Paul S.; Gorlick, Richard; Koutcher, Jason A.; Ballon, Douglas.

In: Radiology, Vol. 228, No. 1, 01.07.2003, p. 271-278.

Research output: Contribution to journalArticle

Dyke, JP, Panicek, DM, Healey, JH, Meyers, PA, Huvos, AG, Schwartz, LH, Thaler, HT, Tofts, PS, Gorlick, R, Koutcher, JA & Ballon, D 2003, 'Osteogenic and ewing sarcomas: Estimation of necrotic fraction during induction chemotherapy with dynamic contrastenhanced MR imaging', Radiology, vol. 228, no. 1, pp. 271-278. https://doi.org/10.1148/radiol.2281011651
Dyke, Jonathan P. ; Panicek, David M. ; Healey, John H. ; Meyers, Paul A. ; Huvos, Andrew G. ; Schwartz, Lawrence H. ; Thaler, Howard T. ; Tofts, Paul S. ; Gorlick, Richard ; Koutcher, Jason A. ; Ballon, Douglas. / Osteogenic and ewing sarcomas : Estimation of necrotic fraction during induction chemotherapy with dynamic contrastenhanced MR imaging. In: Radiology. 2003 ; Vol. 228, No. 1. pp. 271-278.
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