Osmotic swelling of phospholipid vesicles causes them to fuse with a planar phospholipid bilayer membrane

Fredric S. Cohen, Myles H. Akabas, Alan Finkelstein

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Abstract

Fusion of phospholipid vesicles with planar bilayer membranes occurs if the vesicles that contact the planar membrane swell osmotically after the replacement in their medium of an impermeant solute by a permeant one. This finding directly demonstrates that osmotic swelling is a driving force for vesicle-planar membrane fusion. The method used to induce vesicle swelling and fusion may have relevance for biological systems.

Original languageEnglish (US)
Pages (from-to)458-460
Number of pages3
JournalScience
Volume217
Issue number4558
DOIs
Publication statusPublished - Jan 1 1982

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