Orphan nuclear receptors as targets for drug development

Subhajit Mukherjee, Sridhar Mani

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Orphan nuclear receptors regulate diverse biological processes. These important molecules are ligand-activated transcription factors that act as natural sensors for a wide range of steroid hormones and xenobiotic ligands. Because of their importance in regulating various novel signaling pathways, recent research has focused on identifying xenobiotics targeting these receptors for the treatment of multiple human diseases. In this review, we will highlight these receptors in several physiologic and pathophysiologic actions and demonstrate how their functions can be exploited for the successful development of newer drugs.

Original languageEnglish (US)
Pages (from-to)1439-1468
Number of pages30
JournalPharmaceutical Research
Volume27
Issue number8
DOIs
StatePublished - Aug 2010

Fingerprint

Orphan Nuclear Receptors
Xenobiotics
Steroid hormones
Ligands
Biological Phenomena
Pharmaceutical Preparations
Transcription Factors
Steroids
Hormones
Molecules
Sensors
Research

Keywords

  • agonist
  • antagonist
  • ligand binding domain
  • orphan nuclear receptor

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Organic Chemistry
  • Molecular Medicine
  • Pharmacology (medical)
  • Biotechnology
  • Pharmacology
  • Medicine(all)

Cite this

Orphan nuclear receptors as targets for drug development. / Mukherjee, Subhajit; Mani, Sridhar.

In: Pharmaceutical Research, Vol. 27, No. 8, 08.2010, p. 1439-1468.

Research output: Contribution to journalArticle

Mukherjee, Subhajit ; Mani, Sridhar. / Orphan nuclear receptors as targets for drug development. In: Pharmaceutical Research. 2010 ; Vol. 27, No. 8. pp. 1439-1468.
@article{13c3fb3c25cc494f948532c881b49bf5,
title = "Orphan nuclear receptors as targets for drug development",
abstract = "Orphan nuclear receptors regulate diverse biological processes. These important molecules are ligand-activated transcription factors that act as natural sensors for a wide range of steroid hormones and xenobiotic ligands. Because of their importance in regulating various novel signaling pathways, recent research has focused on identifying xenobiotics targeting these receptors for the treatment of multiple human diseases. In this review, we will highlight these receptors in several physiologic and pathophysiologic actions and demonstrate how their functions can be exploited for the successful development of newer drugs.",
keywords = "agonist, antagonist, ligand binding domain, orphan nuclear receptor",
author = "Subhajit Mukherjee and Sridhar Mani",
year = "2010",
month = "8",
doi = "10.1007/s11095-010-0117-7",
language = "English (US)",
volume = "27",
pages = "1439--1468",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "Springer New York",
number = "8",

}

TY - JOUR

T1 - Orphan nuclear receptors as targets for drug development

AU - Mukherjee, Subhajit

AU - Mani, Sridhar

PY - 2010/8

Y1 - 2010/8

N2 - Orphan nuclear receptors regulate diverse biological processes. These important molecules are ligand-activated transcription factors that act as natural sensors for a wide range of steroid hormones and xenobiotic ligands. Because of their importance in regulating various novel signaling pathways, recent research has focused on identifying xenobiotics targeting these receptors for the treatment of multiple human diseases. In this review, we will highlight these receptors in several physiologic and pathophysiologic actions and demonstrate how their functions can be exploited for the successful development of newer drugs.

AB - Orphan nuclear receptors regulate diverse biological processes. These important molecules are ligand-activated transcription factors that act as natural sensors for a wide range of steroid hormones and xenobiotic ligands. Because of their importance in regulating various novel signaling pathways, recent research has focused on identifying xenobiotics targeting these receptors for the treatment of multiple human diseases. In this review, we will highlight these receptors in several physiologic and pathophysiologic actions and demonstrate how their functions can be exploited for the successful development of newer drugs.

KW - agonist

KW - antagonist

KW - ligand binding domain

KW - orphan nuclear receptor

UR - http://www.scopus.com/inward/record.url?scp=77955470799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955470799&partnerID=8YFLogxK

U2 - 10.1007/s11095-010-0117-7

DO - 10.1007/s11095-010-0117-7

M3 - Article

C2 - 20372994

AN - SCOPUS:77955470799

VL - 27

SP - 1439

EP - 1468

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 8

ER -