Orphan nuclear receptors as targets for drug development

Subhajit Mukherjee, Sridhar Mani

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Orphan nuclear receptors regulate diverse biological processes. These important molecules are ligand-activated transcription factors that act as natural sensors for a wide range of steroid hormones and xenobiotic ligands. Because of their importance in regulating various novel signaling pathways, recent research has focused on identifying xenobiotics targeting these receptors for the treatment of multiple human diseases. In this review, we will highlight these receptors in several physiologic and pathophysiologic actions and demonstrate how their functions can be exploited for the successful development of newer drugs.

Original languageEnglish (US)
Pages (from-to)1439-1468
Number of pages30
JournalPharmaceutical Research
Volume27
Issue number8
DOIs
Publication statusPublished - Aug 1 2010

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Keywords

  • agonist
  • antagonist
  • ligand binding domain
  • orphan nuclear receptor

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

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