Origine paternelle du chromosome 18 surnumeraire dans la trisomie 18

K. H. Ramesh, R. S. Verma

Research output: Contribution to journalShort surveypeer-review

11 Scopus citations

Abstract

Trisomy 18 (Edwards syndrome) is the second most common trisomy in human. The parental origin of the additional chromosome leading to meiotic errors is imperative to understand the etiology of trisomy 18. We compiled the data on 171 cases where meiotic error is provided. The paternal meiotic error occurred in 7% of the cases while in 93% of the cases nondisjunction took place in the mother. There were 28 cases (16%) where nondisjunction took place in meiosis I (MI), 53 cases (31%) in meiosis II (MII) and in 90 cases (53%) either the error was postzygotic mitosis or the dysfunctional stages could not be determined. The age distribution could be found in 119 cases and a conclusion could not be drawn as there were only 11 cases where paternal nondisjunction was noted.

Original languageEnglish (US)
Pages (from-to)110-112
Number of pages3
JournalAnnales de Genetique
Volume39
Issue number2
StatePublished - Aug 6 1996
Externally publishedYes

Keywords

  • Edwards syndrome
  • Meiosis I and II
  • Nondisjunction
  • Trisomy 18

ASJC Scopus subject areas

  • Genetics

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