Origin of the Lamina Propria Dendritic Cell Network

Milena Bogunovic, Florent Ginhoux, Julie Helft, Limin Shang, Daigo Hashimoto, Melanie Greter, Kang Liu, Claudia Jakubzick, Molly A. Ingersoll, Marylene Leboeuf, E. Richard Stanley, Michel Nussenzweig, Sergio A. Lira, Gwendalyn J. Randolph, Miriam Merad

Research output: Contribution to journalArticle

583 Citations (Scopus)

Abstract

CX3CR1+ and CD103+ dendritic cells (DCs) in intestinal lamina propria play a key role in mucosal immunity. However, the origin and the developmental pathways that regulate their differentiation in the lamina propria remain unclear. We showed that monocytes gave rise exclusively to CD103-CX3CR1+ lamina propria DCs under the control of macrophage-colony-stimulating factor receptor (M-CSFR) and Fms-like thyrosine kinase 3 (Flt3) ligands. In contrast, common DC progenitors (CDP) and pre-DCs, which give rise to lymphoid organ DCs but not to monocytes, differentiated exclusively into CD103+CX3CR1- lamina propria DCs under the control of Flt3 and granulocyte-macrophage-colony-stimulating factor receptor (GM-CSFR) ligands. CD103+CX3CR1- DCs but not CD103-CX3CR1+ DCs in the lamina propria constitutively expressed CCR7 and were the first DCs to transport pathogenic Salmonella from the intestinal tract to the mesenteric lymph nodes. Altogether, these results underline the diverse origin of the lamina propria DC network and identify mucosal DCs that arise from pre-DCs as key sentinels of the gut immune system.

Original languageEnglish (US)
Pages (from-to)513-525
Number of pages13
JournalImmunity
Volume31
Issue number3
DOIs
StatePublished - Sep 18 2009

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Dendritic Cells
Mucous Membrane
Monocytes
Phosphotransferases
Granulocyte-Macrophage Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor Receptors
Ligands
Mucosal Immunity
Salmonella
Immune System
Lymph Nodes

Keywords

  • CELLIMMUNO
  • MOLIMMUNO

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Bogunovic, M., Ginhoux, F., Helft, J., Shang, L., Hashimoto, D., Greter, M., ... Merad, M. (2009). Origin of the Lamina Propria Dendritic Cell Network. Immunity, 31(3), 513-525. https://doi.org/10.1016/j.immuni.2009.08.010

Origin of the Lamina Propria Dendritic Cell Network. / Bogunovic, Milena; Ginhoux, Florent; Helft, Julie; Shang, Limin; Hashimoto, Daigo; Greter, Melanie; Liu, Kang; Jakubzick, Claudia; Ingersoll, Molly A.; Leboeuf, Marylene; Stanley, E. Richard; Nussenzweig, Michel; Lira, Sergio A.; Randolph, Gwendalyn J.; Merad, Miriam.

In: Immunity, Vol. 31, No. 3, 18.09.2009, p. 513-525.

Research output: Contribution to journalArticle

Bogunovic, M, Ginhoux, F, Helft, J, Shang, L, Hashimoto, D, Greter, M, Liu, K, Jakubzick, C, Ingersoll, MA, Leboeuf, M, Stanley, ER, Nussenzweig, M, Lira, SA, Randolph, GJ & Merad, M 2009, 'Origin of the Lamina Propria Dendritic Cell Network', Immunity, vol. 31, no. 3, pp. 513-525. https://doi.org/10.1016/j.immuni.2009.08.010
Bogunovic M, Ginhoux F, Helft J, Shang L, Hashimoto D, Greter M et al. Origin of the Lamina Propria Dendritic Cell Network. Immunity. 2009 Sep 18;31(3):513-525. https://doi.org/10.1016/j.immuni.2009.08.010
Bogunovic, Milena ; Ginhoux, Florent ; Helft, Julie ; Shang, Limin ; Hashimoto, Daigo ; Greter, Melanie ; Liu, Kang ; Jakubzick, Claudia ; Ingersoll, Molly A. ; Leboeuf, Marylene ; Stanley, E. Richard ; Nussenzweig, Michel ; Lira, Sergio A. ; Randolph, Gwendalyn J. ; Merad, Miriam. / Origin of the Lamina Propria Dendritic Cell Network. In: Immunity. 2009 ; Vol. 31, No. 3. pp. 513-525.
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