Oriented Cell Division as a Response to Cell Death and Cell Competition

Wei Li, Abhijit Kale, Nicholas E. Baker

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The imaginal disc epithelia that give rise to the adult ectoderm of Drosophila can compensate to produce normal adult organs after damage. We looked at the local response to cell death by using two genetic methods to elevate cell death rates. During cell competition, sporadic cell death occurs predictably along the boundaries between populations of competing wild-type and "Minute" cells (M/+) [1]. Boundaries between M/+ and wild-type populations show an unusual degree of mixing, associated with mitotic reorientation of wild-type cells toward M/+ territory that they take over. Apoptosis of M/+ cells was the cue, and reoriented mitosis required the planar cell polarity genes dachsous, fat, and atrophin. Clones mutated for pineapple eye, an essential gene, elevate apoptosis by a noncompetitive mechanism [2]. Mitosis was also reoriented near cells mutant for pineapple eye, likewise dependent on the planar cell polarity genes. These findings show that planar cell polarity genes are required for responses to cell death. Oriented mitosis may help maintain morphology as dividing cells replace those that have been lost.

Original languageEnglish (US)
Pages (from-to)1821-1826
Number of pages6
JournalCurrent Biology
Volume19
Issue number21
DOIs
StatePublished - Nov 17 2009

Fingerprint

Cell death
Cell Division
cell division
cell death
Cell Death
Genes
Cells
Cell Polarity
Mitosis
mitosis
Ananas
pineapples
cells
Apoptosis
apoptosis
eyes
Imaginal Discs
imaginal discs
Ectoderm
genes

Keywords

  • CELLBIO
  • DEVBIO

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Oriented Cell Division as a Response to Cell Death and Cell Competition. / Li, Wei; Kale, Abhijit; Baker, Nicholas E.

In: Current Biology, Vol. 19, No. 21, 17.11.2009, p. 1821-1826.

Research output: Contribution to journalArticle

Li, Wei ; Kale, Abhijit ; Baker, Nicholas E. / Oriented Cell Division as a Response to Cell Death and Cell Competition. In: Current Biology. 2009 ; Vol. 19, No. 21. pp. 1821-1826.
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