Organization of vesicular trafficking in epithelia

Enrique Rodriguez-Boulan, Geri Kreitzer, Anne Müsch

Research output: Contribution to journalReview article

466 Scopus citations

Abstract

Experiments using mammalian epithelial cell lines have elucidated biosynthetic and recycling pathways for apical and basolateral plasma-membrane proteins, and have identified components that guide apical and basolateral proteins along these pathways. These components include apical and basolateral sorting signals, adaptors for basolateral signals, and docking and fusion proteins for vesicular trafficking. Recent live-cell-imaging studies provide a real-time view of sorting processes in epithelial cells, including key roles for actin, microtubules and motors in the organization of post-Golgi trafficking.

Original languageEnglish (US)
Pages (from-to)233-247
Number of pages15
JournalNature Reviews Molecular Cell Biology
Volume6
Issue number3
DOIs
StatePublished - Mar 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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