Organization of vesicular trafficking in epithelia

Enrique Rodriguez-Boulan, Geri Kreitzer, Anne Muesch

Research output: Contribution to journalArticle

456 Citations (Scopus)

Abstract

Experiments using mammalian epithelial cell lines have elucidated biosynthetic and recycling pathways for apical and basolateral plasma-membrane proteins, and have identified components that guide apical and basolateral proteins along these pathways. These components include apical and basolateral sorting signals, adaptors for basolateral signals, and docking and fusion proteins for vesicular trafficking. Recent live-cell-imaging studies provide a real-time view of sorting processes in epithelial cells, including key roles for actin, microtubules and motors in the organization of post-Golgi trafficking.

Original languageEnglish (US)
Pages (from-to)233-247
Number of pages15
JournalNature Reviews Molecular Cell Biology
Volume6
Issue number3
DOIs
StatePublished - Mar 2005
Externally publishedYes

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Epithelium
Epithelial Cells
Biosynthetic Pathways
Protein Transport
Microtubules
Actins
Blood Proteins
Membrane Proteins
Cell Membrane
Cell Line
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Organization of vesicular trafficking in epithelia. / Rodriguez-Boulan, Enrique; Kreitzer, Geri; Muesch, Anne.

In: Nature Reviews Molecular Cell Biology, Vol. 6, No. 3, 03.2005, p. 233-247.

Research output: Contribution to journalArticle

Rodriguez-Boulan, Enrique ; Kreitzer, Geri ; Muesch, Anne. / Organization of vesicular trafficking in epithelia. In: Nature Reviews Molecular Cell Biology. 2005 ; Vol. 6, No. 3. pp. 233-247.
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