TY - JOUR
T1 - Organization of vesicular trafficking in epithelia
AU - Rodriguez-Boulan, Enrique
AU - Kreitzer, Geri
AU - Müsch, Anne
N1 - Funding Information:
We gratefully acknowledge the support of the National Institutes of Health (E.R.-B.), a Jules and Doris Stein Professorship from the Research to Prevent Blindness Foundation (E.R.-B.) and a Career Development Award from the American Heart Association (A.M.). We are grateful to A. Gonzalez, T. McGraw, J. Nelson and V. Malhotra for useful comments on the manuscript. Our goal to cite mostly primary references is not free of arbitrariness given the limited number of references allowed by the format of the review and the rapid growth of the field. We apologize that several excellent papers could not be cited individually and could only be discussed indirectly or through reviews.
PY - 2005/3
Y1 - 2005/3
N2 - Experiments using mammalian epithelial cell lines have elucidated biosynthetic and recycling pathways for apical and basolateral plasma-membrane proteins, and have identified components that guide apical and basolateral proteins along these pathways. These components include apical and basolateral sorting signals, adaptors for basolateral signals, and docking and fusion proteins for vesicular trafficking. Recent live-cell-imaging studies provide a real-time view of sorting processes in epithelial cells, including key roles for actin, microtubules and motors in the organization of post-Golgi trafficking.
AB - Experiments using mammalian epithelial cell lines have elucidated biosynthetic and recycling pathways for apical and basolateral plasma-membrane proteins, and have identified components that guide apical and basolateral proteins along these pathways. These components include apical and basolateral sorting signals, adaptors for basolateral signals, and docking and fusion proteins for vesicular trafficking. Recent live-cell-imaging studies provide a real-time view of sorting processes in epithelial cells, including key roles for actin, microtubules and motors in the organization of post-Golgi trafficking.
UR - http://www.scopus.com/inward/record.url?scp=14644401811&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14644401811&partnerID=8YFLogxK
U2 - 10.1038/nrm1593
DO - 10.1038/nrm1593
M3 - Review article
C2 - 15738988
AN - SCOPUS:14644401811
SN - 1471-0072
VL - 6
SP - 233
EP - 247
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 3
ER -