Orbital T-cell Lymphoma Human T-cell Leukemia Virus-I Infection

Simeon A. Lauer, Joel Fischer, Joan Jones, Samuel Gartner, Janice Dutcher, James A. Hoxie

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

This is the first report of orbital involvement in systemic adult T-cell leukemia/lymphoma (ATLL). The etiologic agent of ATLL is the human T-cell leukemia virus-I (HTLV-I), the first retrovirus demonstrated to induce cancer in humans. The diagnosis of ATLL is based on characteristic clinicopathologic features in combination with serologic or virologic evidence of HTLV-I infection. Serum antibodies to HTLV-I were identified by immunofluorescent microscopy. Viral particles characteristic of HTLV-I were found in a culture of the patient's peripheral blood lymphocytes. The patient was a native of the Caribbean, one of the known endemic foci of HTLV-I infection. Adult T-cell leukemia/lymphoma should be considered in the differential diagnosis of orbital T-cell lymphomas.

Original languageEnglish (US)
Pages (from-to)110-115
Number of pages6
JournalOphthalmology
Volume95
Issue number1
DOIs
StatePublished - 1988

Keywords

  • adult T-cell leukemia/lymphoma
  • human T-cell leukemia virus-I
  • orbit

ASJC Scopus subject areas

  • Ophthalmology

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